Search Results - "Gammon, David W"

South African actinobacteria: A treasure trove of novel bioactive metabolites for drug discovery by Acquah, Kojo S, Gammon, David W, Beukes, Denzil R

“…Although South Africa is known as one of the most biodiverse countries in the world, based on its unique plants and animals, microorganisms have received much…”
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Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners by Acquah, Kojo Sekyi, Beukes, Denzil R, Warner, Digby F, Meyers, Paul R, Sunassee, Suthananda N, Maglangit, Fleurdeliz, Deng, Hai, Jaspars, Marcel, Gammon, David W

“…In this paper, we report on the chemistry of the rare South African Actinomycete strain SK5, a prolific producer of hydroxamate siderophores and their…”
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Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts by Acquah, Kojo Sekyi, Beukes, Denzil R, Seldon, Ronnett, Jordaan, Audrey, Sunassee, Suthananda N, Warner, Digby F, Gammon, David W

“…Tuberculosis (TB) remains a public health crisis, requiring the urgent identification of new anti-mycobacterial drugs. We screened several organic and aqueous…”
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Plants, people and health: three disciplines at work in Namaqualand by Green, Lesley, Gammon, David W, Hoffman, Michael T, Cohen, Joshua, Hilgart, Amelia, Morrell, Robert. G, Verran, Helen, Wheat, Nicola

“…In Paulshoek, Namaqualand, three research projects focusing on medicinal plants were developed concurrently. The projects were based in the disciplines of…”
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Tandem Epoxidation-Alcoholysis or Epoxidation-Hydrolysis of Glycals Catalyzed by Titanium(IV) Isopropoxide or Venturello's Phosphotungstate Complex by Levecque, Pieter, Gammon, David W., Kinfe, Henok Hadgu, Jacobs, Pierre, De Vos, Dirk, Sels, Bert

“…Venturello’s phosphotungstate complex and titanium(IV) isopropoxide [Ti(O‐i‐Pr)4] were successfully used as catalysts for the epoxidation‐alcoholysis of…”
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Influence of Pore and Crystal Size of Crystalline Titanosilicates on Phenol Hydroxylation in Different Solvents by Wilkenhöner, Uwe, Langhendries, Gunther, van Laar, Frederik, Baron, Gino V., Gammon, David W., Jacobs, Pierre A., van Steen, Eric

“…The hydroxylation of phenol into catechol and hydroquinone with aqueous H2O2 (30%) and titanium-substituted molecular sieves (TS-1 and Al-free Ti-Beta) was…”
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Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A by Slättegård, Rikard, Teodorovic, Peter, Kinfe, Henok Hadgu, Ravenscroft, Neil, Gammon, David W, Oscarson, Stefan

“…Four differently substituted trimers of the CPS repeating unit have been synthesised in order to investigate the dependence on oligosaccharide size,…”
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Preparation and antimalarial activity of a novel class of carbohydrate-derived, fused thiochromans by Kinfe, Henok H., Moshapo, Paseka T., Makolo, Felix L., Gammon, David W., Ehlers, Martin, Schmuck, Carsten

“…A novel class of fused thiochroman derivatives has been prepared by an efficient and versatile synthetic procedure involving nucleophilic displacement of the…”
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Extending the scope of the Ferrier reaction: fragmentation-rearrangement reactions of selectively substituted 1,2-cyclopropanated glucose derivatives by Munyololo, Muganza, Gammon, David W., Mohrholz, Ilka

“…[Display omitted] ► 1,2-Cyclopropanated glucose bearing an ester is unreactive with Lewis acids. ► Reduction and acetylation gives the corresponding…”
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Synthesis of 2-Deoxy-2-C-Alkylglucosides of myo-Inositol as possible inhibitors of a N-Deacetylase enzyme in the biosynthesis of mycothiol by Gammon, David W., Hunter, Roger, Steenkamp, Daniel J., Mudzunga, Theophilus T.

“…Two new analogues of 1- d-1- O-(2-acetamido-2-deoxy-α- d-glucopyranosyl)- myo-inositol, a biosynthetic intermediate in the production of mycothiol in the…”
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Conformational preferences of plumbagin with phenyl-1-thioglucoside conjugates in solution and bound to MshB determined by aromatic association by Rogers, Ian L., Gammon, David W., Naidoo, Kevin J.

“…[Display omitted] ► Pharmacophore shows 95% inhibition of the mycothiol biosynthesis enzyme MshB. ► Docking calculations are inconsistent with experimental…”
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Armed–disarmed effect on the stability of cysteine thioglucosides by Nokwequ, Mbulelo G., Nkambule, Comfort M., Gammon, David W.

“…[Display omitted] ► Cysteine glucosides have variable stabilities depending on the glycosyl donor protecting groups. ► Armed cysteine thioglucosides with free…”
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Conjugates of plumbagin and phenyl-2-amino-1-thioglucoside inhibit MshB, a deacetylase involved in the biosynthesis of mycothiol by Gammon, David W., Steenkamp, Daniel J., Mavumengwana, Vuyo, Marakalala, Mohlopheni J., Mudzunga, Theophilus T., Hunter, Roger, Munyololo, Muganza

“…Compounds 1a–d with plumbagin tethered to a phenyl-2-amino-thioglucoside are potent inhibitors of the amidase mshB in the Mycobacteria…”
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Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa) by Bamuamba, Kapinga, Gammon, David W., Meyers, Paul, Dijoux-Franca, Marie-Genevieve, Scott, Gillian

“…Five plants used in traditional medicine in the Western Cape Province of South Africa, have been investigated for anti-mycobacterial activity: Olea capensis,…”
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Efficient regioselective protection of myo-inositol via facile protecting group migration by Nkambule, Comfort M., Kwezi, Nomfundo W., Kinfe, Henok H., Nokwequ, Mbulelo G., Gammon, David W., Oscarson, Stefan, Karlsson, Erik

“…A cis-1,2-cyclohexanediol, 1,4,5,6-tetra- O-benzyl- myo-inositol, was selectively protected at the axial C2-hydroxyl via acid-mediated rearrangement of the…”
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Synthesis of fused bicyclic thioglycosides of N-acylated glucosamine as analogues of mycothiol by Slättegård, Rikard, Gammon, David W., Oscarson, Stefan

“…The synthesis of a fused bicyclic thioglycoside analogue of mycothiol,…”
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Retro-Diels-Alder Reactions of Masked Cyclopentadienones Catalyzed by Heterogeneous Brønsted Acids by Demuynck, Anneleen L. W., Levecque, Pieter, Kidane, Aklilu, Gammon, David W., Sickle, Eugene, Jacobs, Pierre A., De Vos, Dirk E., Sels, Bert F.

“…The zeolite H‐Beta catalyzes the retro‐Diels–Alder reaction of a range of cyclopentadiene cyclo‐adducts at moderate temperatures and ambient pressure, in the…”
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Synthesis of mycothiol, 1D-1-O-(2-[N-acetyl-l-cysteinyl]amino-2-deoxy-α-d-glucopyranosyl)-myo-inositol, principal low molecular mass thiol in the actinomycetes by Jardine, M.Anwar, Spies, Hendrik S.C, Nkambule, Comfort M, Gammon, David W, Steenkamp, Daniel J

“…Members of the actinomycetes produce 1D-1-O-(2-[N-acetyl-l-cysteinyl]amino-2-deoxy-α-d-glucopyranosyl)-myo-inositol or mycothiol 1 as principal low molecular…”
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Mechanistic Insight into the Conversion of Tetrose Sugars to Novel α-Hydroxy Acid Platform Molecules by Dusselier, Michiel, Van Wouwe, Pieter, de Clippel, Filip, Dijkmans, Jan, Gammon, David W., Sels, Bert F.

“…α‐Hydroxy acids (AHAs) such as lactic acid are considered platform molecules in the biorefinery concept and have high‐end applications in solvents and…”
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Synthesis of resorcinol from meta-phenylenediamine in the presence of zirconium phosphates by Brack, Bryan, Gammon, David W, Steen, Eric van

“…Aqueous meta-phenylenediamine was converted to resorcinol and ammonia in the presence of layered α-zirconium phosphates (α-ZrP) and γ-zirconium phosphates…”
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