Search Results - "Gamez, Graciela"
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1
Metastatic cells are preferentially vulnerable to lysosomal inhibition
Published in Proceedings of the National Academy of Sciences - PNAS (04-09-2018)“…Molecular alterations that confer phenotypic advantages to tumors can also expose specific therapeutic vulnerabilities. To search for potential treatments that…”
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2
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent
Published in Autophagy (01-10-2014)“…Chloroquine (CQ) is an antimalarial drug and late-stage inhibitor of autophagy currently FDA-approved for use in the treatment of rheumatoid arthritis and…”
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RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis
Published in EMBO reports (01-06-2015)“…In a synthetic lethality/viability screen, we identified the serine–threonine kinase RIP1 (RIPK1) as a gene whose knockdown is highly selected against during…”
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Mitochondrially Mediated Integrin αIIbβ3 Protein Inactivation Limits Thrombus Growth
Published in The Journal of biological chemistry (18-10-2013)“…When platelets are strongly stimulated, a procoagulant platelet subpopulation is formed that is characterized by phosphatidylserine (PS) exposure and epitope…”
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Anti-Inositolglycan Antibodies Selectively Block Some of the Actions of Insulin in Intact BC3H1 Cells
Published in Proceedings of the National Academy of Sciences - PNAS (01-02-1990)“…We have studied the mechanism of generation of insulin mediators by using specific antibodies raised against the oligosaccharide anchor of membrane proteins…”
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Human Immunodeficiency Virus Type 1 Pathogenesis in SCID-hu Mice Correlates with Syncytium-Inducing Phenotype and Viral Replication
Published in Journal of Virology (01-04-2000)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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7
RIP 1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis
Published in EMBO reports (01-06-2015)Get full text
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8
Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: Relation to endothelium-dependent vasodilation
Published in Circulation (New York, N.Y.) (18-03-2003)“…Increased inactivation of nitric oxide by superoxide (O2*-) contributes to endothelial dysfunction in patients with coronary disease (CAD). We therefore…”
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Mitochondrially-Mediated Platelet Integrin AlphaIIbbeta3 Inactivation Limits Platelet Recruitment and Thrombus Growth
Published in Blood (18-11-2011)“…Abstract 3251 Platelet stimulation with strong agonist(s) results in the formation of a phenotypically unique platelet subpopulation known as procoagulant…”
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10
Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice
Published in American journal of physiology. Heart and circulatory physiology (01-01-2005)“…Protein levels and polymorphisms of p22(phox) have been suggested to modulate vascular NAD(P)H oxidase activity and vascular production of reactive oxygen…”
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