Search Results - "Gambus, Agnieszka"

Mechanisms of eukaryotic replisome disassembly by Moreno, Sara Priego, Gambus, Agnieszka

“…DNA replication is a complex process that needs to be executed accurately before cell division in order to maintain genome integrity. DNA replication is…”
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Polyubiquitylation drives replisome disassembly at the termination of DNA replication by Moreno, Sara Priego, Bailey, Rachael, Campion, Nicholas, Herron, Suzanne, Gambus, Agnieszka

“…Resolution of replication forks during termination of DNA replication is essential for accurate duplication of eukaryotic genomes. Here we present evidence…”
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A key role for the GINS complex at DNA replication forks by Labib, Karim, Gambus, Agnieszka

“…The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome…”
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A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation by Hadzhiev, Yavor, Qureshi, Haseeb K., Wheatley, Lucy, Cooper, Ledean, Jasiulewicz, Aleksandra, Van Nguyen, Huy, Wragg, Joseph W., Poovathumkadavil, Divyasree, Conic, Sascha, Bajan, Sarah, Sik, Attila, Hutvàgner, György, Tora, Làszlò, Gambus, Agnieszka, Fossey, John S., Müller, Ferenc

“…Most metazoan embryos commence development with rapid, transcriptionally silent cell divisions, with genome activation delayed until the mid-blastula…”
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A Decade of Discovery-Eukaryotic Replisome Disassembly at Replication Termination by Jones, Rebecca M, Reynolds-Winczura, Alicja, Gambus, Agnieszka

“…The eukaryotic replicative helicase (CMG complex) is assembled during DNA replication initiation in a highly regulated manner, which is described in depth by…”
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TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells by Scaramuzza, Shaun, Jones, Rebecca M., Sadurni, Martina Muste, Reynolds-Winczura, Alicja, Poovathumkadavil, Divyasree, Farrell, Abigail, Natsume, Toyoaki, Rojas, Patricia, Cuesta, Cyntia Fernandez, Kanemaki, Masato T., Saponaro, Marco, Gambus, Agnieszka

“…Cell division is the basis for the propagation of life and requires accurate duplication of all genetic information. DNA damage created during replication…”
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Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1 by Colding-Christensen, Camilla S., Kakulidis, Ellen S., Arroyo-Gomez, Javier, Hendriks, Ivo A., Arkinson, Connor, Fábián, Zita, Gambus, Agnieszka, Mailand, Niels, Duxin, Julien P., Nielsen, Michael L.

“…Ubiquitin widely modifies proteins, thereby regulating most cellular functions. The complexity of ubiquitin signalling necessitates unbiased methods enabling…”
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The MCM8-MCM9 Complex Promotes RAD51 Recruitment at DNA Damage Sites To Facilitate Homologous Recombination by Park, Jonghoon, Long, David T., Lee, Kyung Yong, Abbas, Tarek, Shibata, Etsuko, Negishi, Masamitsu, Luo, Yunhai, Schimenti, John C., Gambus, Agnieszka, Walter, Johannes C., Dutta, Anindya

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Protocol for the purification of replisomes from the Xenopus laevis egg extract system for single-particle cryo-EM analysis by Passaretti, Paolo, Cvetkovic, Milos A., Costa, Alessandro, Gambus, Agnieszka

“…Here, we present a large-scale FLAG immunoprecipitation protocol to isolate large protein complexes driving DNA replication at replicating chromatin assembled…”
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Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins by Gillespie, Peter J., Gambus, Agnieszka, Blow, J. Julian

“…The use of cell-free extracts prepared from eggs of the South African clawed toad, Xenopus laevis, has led to many important discoveries in cell cycle…”
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Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity by Priego Moreno, Sara, Jones, Rebecca M, Poovathumkadavil, Divyasree, Scaramuzza, Shaun, Gambus, Agnieszka

“…We have shown previously that the process of replication machinery (replisome) disassembly at the termination of DNA replication forks in the S-phase is driven…”
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Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo by Labib, Karim, Kanemaki, Masato, Sanchez-Diaz, Alberto, Gambus, Agnieszka

“…Evolutionarily diverse eukaryotic cells share many conserved proteins of unknown function. Some are essential for cell viability, emphasising their importance…”
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Characterizing replisome disassembly in human cells by Jones, Rebecca M., Ruiz, Joaquin Herrero, Scaramuzza, Shaun, Nath, Sarmi, Liu, Chaoyu, Henklewska, Marta, Natsume, Toyoaki, Bristow, Robert G., Romero, Francisco, Kanemaki, Masato T., Gambus, Agnieszka

“…To ensure timely duplication of the entire eukaryotic genome, thousands of replication machineries (replisomes) act on genomic DNA at any time during S phase…”
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CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis by Sonneville, Remi, Moreno, Sara Priego, Knebel, Axel, Johnson, Clare, Hastie, C. James, Gartner, Anton, Gambus, Agnieszka, Labib, Karim

“…Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase…”
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Xenopus Mcm10 is a CDK-substrate required for replication fork stability by Chadha, Gaganmeet Singh, Gambus, Agnieszka, Gillespie, Peter J., Blow, J. Julian

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Replisome Disassembly At The Termination Of Eukaryotic Replication Forks by Gambus, Agnieszka

“…Abstract only To ensure duplication of the whole genome DNA replication initiates from thousands of origins of replication. The pre‐loaded inactive helicase…”
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The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase by Tarcan, Zeynep, Poovathumkadavil, Divyasree, Skagia, Aggeliki, Gambus, Agnieszka

“…Complex cellular processes are driven by the regulated assembly and disassembly of large multiprotein complexes. While we are beginning to understand the…”
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Termination of Eukaryotic Replication Forks by Gambus, Agnieszka

“…Termination of DNA replication forks takes place when two replication forks coming from neighbouring origins meet each other usually in the midpoint of the…”
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DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation by Kingsley, Georgia, Skagia, Aggeliki, Passaretti, Paolo, Fernandez-Cuesta, Cyntia, Reynolds-Winczura, Alicja, Koscielniak, Kinga, Gambus, Agnieszka

“…Abstract Faithful cell division is the basis for the propagation of life and DNA replication must be precisely regulated. DNA replication stress is a prominent…”
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A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome by Gambus, Agnieszka, van Deursen, Frederick, Polychronopoulos, Dimitrios, Foltman, Magdalena, Jones, Richard C, Edmondson, Ricky D, Calzada, Arturo, Labib, Karim

“…The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still poorly understood. We found previously that many regulatory…”
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