Search Results - "Gamboa, Neira D."

Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate by Romero, Jesús A., Acosta, María E., Gamboa, Neira D., Mijares, Michael R., De Sanctis, Juan B., Charris, Jaime E.

“…[Display omitted] •Compounds were easily synthesized.•Search for new antimalarial and anti-neoplastic drugs for the treatment of malaria and cancer…”
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Antimalarial, antiproliferative, and apoptotic activity of quinoline-chalcone and quinoline-pyrazoline hybrids. A dual action by Charris, Jaime E., Monasterios, Melina C., Acosta, María E., Rodríguez, Miguel A., Gamboa, Neira D., Martínez, Gricelis P., Rojas, Héctor R., Mijares, Michael R., De Sanctis, Juan B.

“…A series of quinoline-chalcone (E) -1-[3 or 4-(7-chloroquinolin-4-ylamino) phenyl]-3-(phenyl substituted) prop-2-ene-1-one ( 4 , 5 ), and quinoline-pyrazoline…”
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Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives by Romero, Jesús A., Acosta, María E., Gamboa, Neira D., Mijares, Michael R., De Sanctis, Juan B., Llovera, Ligia J., Charris, Jaime E.

“…Twenty-eight compounds of the type N´-substituted-2-(5-nitroheterocyclic-2-yl)-3 H -benzo[d]imidazole-5-carboxamide were obtained using as an oxidizing agent…”
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Effect of dequalinium on the oxidative stress in Plasmodium berghei-infected erythrocytes by Rodrigues, Juan R, Gamboa, Neira D

“…The bisquinoline drug dequalinium (DQ) has demonstrated remarkable activity against some infection diseases, including malaria. Oxidative stress represents a…”
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Synthesis and Evaluation of New Antimalarial Phenylurenyl Chalcone Derivatives by Domínguez, José N, León, Caritza, Rodrigues, Juan, Gamboa de Domínguez, Neira, Gut, Jiri, Rosenthal, Philip J

“…Phenylurenyl chalcone derivatives have been synthesized and tested as inhibitors of in vitro development of a chloroquine-resistant strain of Plasmodium…”
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Synthesis of quinolinyl chalcones and evaluation of their antimalarial activity by Domı́nguez, José N, Charris, Jaime E, Lobo, Gricela, Gamboa de Domı́nguez, Neira, Moreno, Marı́a M, Riggione, Flavia, Sanchez, Erlinda, Olson, Jed, Rosenthal, Philip J

“…Quinolinyl chalcones were synthesized and evaluated for their inhibition of the Plasmodium falciparum cystein protease falcipain and their activity against…”
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Cysteine Proteinase Inhibitors Block Early Steps in Hemoglobin Degradation by Cultured Malaria Parasites by Dominguez, Neira D.Gamboa de, Rosenthal, Philip J.

“…Erythrocytic malaria parasites degrade hemoglobin as a source of amino acids for parasite protein synthesis. Cysteine proteinase inhibitors have been shown to…”
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Plasmodium berghei: In vitro and in vivo activity of dequalinium by Rodrigues, Juan Ricardo, Gamboa de Domínguez, Neira

“…Bisquinoline compounds have exhibited remarkable activity in vitro and in vivo against Plasmodium parasites by inhibition of heme detoxification. We have…”
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