Integration of clinical perspective into biomimetic bioreactor design for orthopedics

Integration of clinical perspective into biomimetic bioreactor design for orthopedics

The challenges to accommodate multiple tissue formation metrics in conventional bioreactors have resulted in an increased interest to explore novel bioreactor designs. Bioreactors allow researchers to isolate variables in controlled environments to quantify cell response. While current bioreactor de...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Vol. 110; no. 2; pp. 321 - 337
Main Authors: Drapal, Victoria, Gamble, Jordan M., Robinson, Jennifer L., Tamerler, Candan, Arnold, Paul M., Friis, Elizabeth A.
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-02-2022
Wiley Subscription Services, Inc
Subjects:
Biomedical materials
biomimetic
Biomimetics
bioreactor
Bioreactors
bone
cartilage
Chemical stimuli
clinical relevancy
Environmental effects
Humans
Materials research
Materials science
Microenvironments
multiple stimuli
Orthopedic Procedures
Orthopedics
Review
Stimuli
Tissue engineering
Tissue Engineering - methods
clinical relevancy
multiple stimuli
biomimetic
cartilage
orthopedics
bone
bioreactor
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Summary:The challenges to accommodate multiple tissue formation metrics in conventional bioreactors have resulted in an increased interest to explore novel bioreactor designs. Bioreactors allow researchers to isolate variables in controlled environments to quantify cell response. While current bioreactor designs can effectively provide either mechanical, electrical, or chemical stimuli to the controlled environment, these systems lack the ability to combine all these stimuli simultaneously to better recapitulate the physiological environment. Introducing a dynamic and systematic combination of biomimetic stimuli bioreactor systems could tremendously enhance its clinical relevance in research. Thus, cues from different tissue responses should be studied collectively and included in the design of a biomimetic bioreactor platform. This review begins by providing a summary on the progression of bioreactors from simple to complex designs, focusing on the major advances in bioreactor technology and the approaches employed to better simulate in vivo conditions. The current state of bioreactors in terms of their clinical relevance is also analyzed. Finally, this review provides a comprehensive overview of individual biophysical stimuli and their role in establishing a biomimetic microenvironment for tissue engineering. To date, the most advanced bioreactor designs only incorporate one or two stimuli. Thus, the cell response measured is likely unrelated to the actual clinical performance. Integrating clinically relevant stimuli in bioreactor designs to study cell response can further advance the understanding of physical phenomenon naturally occurring in the body. In the future, the clinically informed biomimetic bioreactor could yield more efficiently translatable results for improved patient care.
Bibliography:Funding information
General Research Fund, University of Kansas, Grant/Award Number: 2234805; KU GO Grant, Grant/Award Number: 1000841; Madison and Lila Self Graduate Fellowship, University of Kansas
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Funding information General Research Fund, University of Kansas, Grant/Award Number: 2234805; KU GO Grant, Grant/Award Number: 1000841; Madison and Lila Self Graduate Fellowship, University of Kansas
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.34929