Search Results - "Gambino, Frederic"

Sensory-evoked LTP driven by dendritic plateau potentials in vivo by Gambino, Frédéric, Pagès, Stéphane, Kehayas, Vassilis, Baptista, Daniela, Tatti, Roberta, Carleton, Alan, Holtmaat, Anthony

“…Whole-cell recordings in mouse somatosensory cortex in vivo show that rhythmic sensory-whisker stimulation induces long-term synaptic potentiation (LTP) in…”
Get full text

Eyes Wide Open on AMPAR Trafficking during Motor Learning by Gambino, Frederic, Choquet, Daniel

“…In this issue of Neuron, Roth et al. (2020) report that the content of GluA1-containing AMPAR at spines and dendrites in vivo in the motor and visual cortex…”
Get full text

Spike-Timing-Dependent Potentiation of Sensory Surround in the Somatosensory Cortex Is Facilitated by Deprivation-Mediated Disinhibition by Gambino, Frédéric, Holtmaat, Anthony

“…Functional maps in the cerebral cortex reorganize in response to changes in experience, but the synaptic underpinnings remain uncertain. Here, we demonstrate…”
Get full text

Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons by Pouchelon, Gabrielle, Gambino, Frédéric, Bellone, Camilla, Telley, Ludovic, Vitali, Ilaria, Lüscher, Christian, Holtmaat, Anthony, Jabaudon, Denis

“…Sensory modality-specific thalamic inputs are shown to instruct the differentiation and function of postsynaptic target neurons in the cortex, thus controlling…”
Get full text

Can NMDA Spikes Dictate Computations of Local Networks and Behavior? by Augusto, Elisabete, Gambino, Frédéric

“…Intelligence is the ability to learn appropriate responses to stimuli and the capacity to master new skills. Synaptic integration at the dendritic level is…”
Get full text

An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization by Pagès, Stéphane, Chenouard, Nicolas, Chéreau, Ronan, Kouskoff, Vladimir, Gambino, Frédéric, Holtmaat, Anthony

“…The organization of sensory maps in the cerebral cortex depends on experience, which drives homeostatic and long-term synaptic plasticity of cortico-cortical…”
Get full text

AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience by Campelo, Tiago, Augusto, Elisabete, Chenouard, Nicolas, de Miranda, Aron, Kouskoff, Vladimir, Camus, Come, Choquet, Daniel, Gambino, Frédéric

“…Cortical plasticity improves behaviors and helps recover lost functions after injury. However, the underlying synaptic mechanisms remain unclear. In mice, we…”
Get full text

Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration by Serrat, Roman, Covelo, Ana, Kouskoff, Vladimir, Delcasso, Sebastien, Ruiz-Calvo, Andrea, Chenouard, Nicolas, Stella, Carol, Blancard, Corinne, Salin, Benedicte, Julio-Kalajzić, Francisca, Cannich, Astrid, Massa, Federico, Varilh, Marjorie, Deforges, Severine, Robin, Laurie M., De Stefani, Diego, Busquets-Garcia, Arnau, Gambino, Frederic, Beyeler, Anna, Pouvreau, Sandrine, Marsicano, Giovanni

“…Intracellular calcium signaling underlies the astroglial control of synaptic transmission and plasticity. Mitochondria-endoplasmic reticulum contacts (MERCs)…”
Get full text

The integration of Gaussian noise by long-range amygdala inputs in frontal circuit promotes fear learning in mice by Aime, Mattia, Augusto, Elisabete, Kouskoff, Vladimir, Campelo, Tiago, Martin, Christelle, Humeau, Yann, Chenouard, Nicolas, Gambino, Frederic

“…Survival depends on the ability of animals to select the appropriate behavior in response to threat and safety sensory cues. However, the synaptic and circuit…”
Get full text

Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1 by Genescu, Ioana, Aníbal-Martínez, Mar, Kouskoff, Vladimir, Chenouard, Nicolas, Mailhes-Hamon, Caroline, Cartonnet, Hugues, Lokmane, Ludmilla, Rijli, Filippo M., López-Bendito, Guillermina, Gambino, Frédéric, Garel, Sonia

“…Cortical wiring relies on guidepost cells and activity-dependent processes that are thought to act sequentially. Here, we show that the construction of layer 1…”
Get full text

X‐linked mental retardation: focus on synaptic function and plasticity by Humeau, Yann, Gambino, Frédéric, Chelly, Jamel, Vitale, Nicolas

“…Among mental disorders, mental retardation has been shown to be caused by various factors including a large array of genetic mutations. On the basis of…”
Get full text

Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling by Jayachandran, Rajesh, Liu, Xiaolong, Bosedasgupta, Somdeb, Müller, Philipp, Zhang, Chun-Lei, Moshous, Despina, Studer, Vera, Schneider, Jacques, Genoud, Christel, Fossoud, Catherine, Gambino, Frédéric, Khelfaoui, Malik, Müller, Christian, Bartholdi, Deborah, Rossez, Helene, Stiess, Michael, Houbaert, Xander, Jaussi, Rolf, Frey, Daniel, Kammerer, Richard A, Deupi, Xavier, de Villartay, Jean-Pierre, Lüthi, Andreas, Humeau, Yann, Pieters, Jean

“…Cognitive and behavioral disorders are thought to be a result of neuronal dysfunction, but the underlying molecular defects remain largely unknown. An…”
Get full text

cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala by Fourcaudot, Elodie, Gambino, Frédéric, Humeau, Yann, Casassus, Guillaume, Shaban, Hamdy, Poulain, Bernard, Lüthi, Andreas

“…NMDA receptor-dependent long-term potentiation (LTP) of glutamatergic synaptic transmission in sensory pathways from auditory thalamus or cortex to the lateral…”
Get full text

Synapses Let Loose for a Change: Inhibitory Synapse Pruning throughout Experience-Dependent Cortical Plasticity by Gambino, Frédéric, Holtmaat, Anthony

“…In this issue of Neuron, Chen et al. (2012) and van Versendaal et al. (2012) used fluorescently tagged gephyrin to track inhibitory synapses in the mouse…”
Get full text

The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability by Zhang, Chun-Lei, Houbaert, Xander, Lepleux, Marilyn, Deshors, Melissa, Normand, Elisabeth, Gambino, Frédéric, Herzog, Etienne, Humeau, Yann

“…The process of learning mainly depends on the ability to store new information, while the ability to retrieve this information and express appropriate…”
Get full text

Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder by Houbaert, Xander, Zhang, Chun-Lei, Gambino, Frédéric, Lepleux, Marilyn, Deshors, Melissa, Normand, Elisabeth, Levet, Florian, Ramos, Mariana, Billuart, Pierre, Chelly, Jamel, Herzog, Etienne, Humeau, Yann

“…Intellectual disorders (IDs) have been regularly associated with morphological and functional deficits at glutamatergic synapses in both humans and rodents…”
Get full text

In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis by Blaise, Sébastien, Kneib, Marie, Rousseau, Adrien, Gambino, Frederic, Chenard, Marie-Pierre, Messadeq, Nadia, Muckenstrum, Martine, Alpy, Fabien, Tomasetto, Catherine, Humeau, Yann, Rio, Marie-Christine

“…Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) are major signal transducers for the TNF and interleukin-1/Toll-like receptor superfamilies. However,…”
Get full text

Forebrain deletion of αGDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections by Bianchi, Veronica, Gambino, Frédéric, Muzio, Luca, Toniolo, Daniela, Humeau, Yann, D'Adamo, Patrizia

“…The GDI1 gene encodes αGDI, which retrieves inactive GDP-bound RAB from membranes to form a cytosolic pool awaiting vesicular release. Mutations in GDI1 are…”
Get full text

Synaptic maturation at cortical projections to the lateral amygdala in a mouse model of Rett syndrome by Gambino, Frédéric, Khelfaoui, Malik, Poulain, Bernard, Bienvenu, Thierry, Chelly, Jamel, Humeau, Yann

“…Rett syndrome (RTT) is a neuro-developmental disorder caused by loss of function of Mecp2--methyl-CpG-binding protein 2--an epigenetic factor controlling DNA…”
Get full text

IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca²⁺-channel and neurite elongation by Gambino, Frédéric, Pavlowsky, Alice, Béglé, Aurélie, Dupont, Jean-Luc, Bahi, Nadia, Courjaret, Raphael, Gardette, Robert, Hadjkacem, Hassen, Skala, Henriette, Poulain, Bernard, Chelly, Jamel, Vitale, Nicolas, Humeau, Yann

“…Null mutations in the IL1-receptor accessory protein-like 1 gene (IL1RAPL1) are responsible for an inherited X-linked form of cognitive impairment. IL1RAPL1…”
Get full text