Search Results - "Galwey, Nicholas W."

A new measure of the effective number of tests, a practical tool for comparing families of non-independent significance tests by Galwey, Nicholas W.

“…p‐Values from tests of significance can be combined using the Šidák correction (or the closely related Bonferroni correction) or Fisher's method, but both…”
Get full text

Potentially avoidable causes of hospitalisation in people with dementia: contemporaneous associations by stage of dementia in a South London clinical cohort by Gungabissoon, Usha, Perera, Gayan, Galwey, Nicholas W, Stewart, Robert

“…ObjectivesTo estimate the frequency of all-cause and ambulatory care sensitive condition (ACSCs)-related hospitalisations among individuals with dementia. In…”
Get full text

Core Concepts in Pharmacoepidemiology: Quantitative Bias Analysis by Brown, Jeremy P., Hunnicutt, Jacob N., Ali, M. Sanni, Bhaskaran, Krishnan, Cole, Ashley, Langan, Sinead M., Nitsch, Dorothea, Rentsch, Christopher T., Galwey, Nicholas W., Wing, Kevin, Douglas, Ian J.

“…ABSTRACT Pharmacoepidemiological studies provide important information on the safety and effectiveness of medications, but the validity of study findings can…”
Get full text

Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells by Wilson, Paul A, Santos Franco, Sara, He, Liu, Galwey, Nicholas W, Meakin, Jackie, McIntyre, Rebecca, McHugh, Simon M, Nolan, Michael A, Spain, Sarah L, Carlson, Thaddeus, Lobera, Mercedes, Rubio, Justin P, Davis, Bill, McCarthy, Linda C

“…RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven…”
Get full text

Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages by Jimenez-Duran, Gisela, Kozole, Joseph, Peltier-Heap, Rachel, Dickinson, Eleanor R., Kwiatkowski, Christopher R., Zappacosta, Francesca, Annan, Roland S., Galwey, Nicholas W., Nichols, Eva-Maria, Modis, Louise K., Triantafilou, Martha, Triantafilou, Kathy, Booty, Lee M.

“…The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading…”
Get full text

A genome-wide association study of neuroticism in a population-based sample by Calboli, Federico C F, Tozzi, Federica, Galwey, Nicholas W, Antoniades, Athos, Mooser, Vincent, Preisig, Martin, Vollenweider, Peter, Waterworth, Dawn, Waeber, Gerard, Johnson, Michael R, Muglia, Pierandrea, Balding, David J

“…Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We…”
Get full text

A Q‐Q plot aids interpretation of the false discovery rate by Galwey, Nicholas W.

“…False discovery rates are routinely controlled by application of the Benjamini–Hochberg step‐up procedure to a set of p‐values. A method is demonstrated for…”
Get full text

Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia by Benzel, Isabel, Bansal, Aruna, Browning, Brian L, Galwey, Nicholas W, Maycox, Peter R, McGinnis, Ralph, Smart, Devi, St Clair, David, Yates, Phillip, Purvis, Ian

“…Evidence of genetic association between the NRG1 (Neuregulin-1) gene and schizophrenia is now well-documented. Furthermore, several recent reports suggest…”
Get full text

Occurrence and Recurrence of Attempted Suicide Among People With Epilepsy by Hesdorffer, Dale C, Ishihara, Lianna, Webb, David J, Mynepalli, Lakshmi, Galwey, Nicholas W, Hauser, W Allen

“…People with epilepsy have a 5-fold increased risk of suicide. Less is known about attempted suicide and whether psychiatric disorders and antiepileptic drugs…”
Get more information

Stability of Blood Eosinophil Count in Patients with COPD in the UK Clinical Practice Research Datalink by Landis, Sarah H, Suruki, Robert, Hilton, Emma, Compton, Chris, Galwey, Nicholas W

“…Blood eosinophil counts may be predictive of corticosteroid response in chronic obstructive pulmonary disease (COPD) patients. However, little is known about…”
Get more information

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach by Bassi, Zuni I, Fillmore, Martin C, Miah, Afjal H, Chapman, Trevor D, Maller, Claire, Roberts, Emma J, Davis, Lauren C, Lewis, Darcy E, Galwey, Nicholas W, Waddington, Kirsty E, Parravicini, Valentino, Macmillan-Jones, Abigail L, Gongora, Celine, Humphreys, Philip G, Churcher, Ian, Prinjha, Rab K, Tough, David F

“…P300/CBP-associated factor (PCAF) and general control nonderepressible 5 (GCN5) are closely related epigenetic proteins, each containing an acetyltransferase…”
Get full text

The association between dementia severity and hospitalisation profile in a newly assessed clinical cohort: the South London and Maudsley case register by Gungabissoon, Usha, Perera, Gayan, Galwey, Nicholas W, Stewart, Robert

“…ObjectivesTo evaluate the risk and common causes of hospitalisation in patients with newly diagnosed dementia and variation by severity of cognitive…”
Get full text

Systemic Fluoroquinolone Use and Risk of Uveitis or Retinal Detachment by Brown, Jeremy P, Wing, Kevin, Evans, Stephen J, Leyrat, Clémence, Mansfield, Kathryn E, Smeeth, Liam, Wong, Angel Y S, Yorston, David, Galwey, Nicholas W, Douglas, Ian J

“…Fluoroquinolone use has been associated with increased risk of uveitis and retinal detachment in noninterventional studies, but the findings have been…”
Get more information

Quantifying possible bias in clinical and epidemiological studies with quantitative bias analysis: common approaches and limitations by Brown, Jeremy P, Hunnicutt, Jacob N, Ali, M Sanni, Bhaskaran, Krishnan, Cole, Ashley, Langan, Sinead M, Nitsch, Dorothea, Rentsch, Christopher T, Galwey, Nicholas W, Wing, Kevin, Douglas, Ian J

Get more information

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis by Baranzini, Sergio E., Galwey, Nicholas W., Wang, Joanne, Khankhanian, Pouya, Lindberg, Raija, Pelletier, Daniel, Wu, Wen, Uitdehaag, Bernard M.J., Kappos, Ludwig, Polman, Chris H., Matthews, Paul M., Hauser, Stephen L., Gibson, Rachel A., Oksenberg, Jorge R., Barnes, Michael R.

“…Genome-wide association studies (GWAS) testing several hundred thousand SNPs have been performed in multiple sclerosis (MS) and other complex diseases…”
Get full text

Populations of two annual clover species evolved in response to 13 years of grazing management and phosphate fertilizer application by Norman, Hayley C., Cocks, Philip S., Galwey, Nicholas W.

“…A Syrian grassland was subject to 13 years of replicated management treatments, namely a factorial design of 0 or 60 kg/ha annually of phosphate fertilizer,…”
Get full text

Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells by Paul A Wilson, Sara Santos Franco, Liu He, Nicholas W Galwey, Jackie Meakin, Rebecca McIntyre, Simon M McHugh, Michael A Nolan, Sarah L Spain, Thaddeus Carlson, Mercedes Lobera, Justin P Rubio, Bill Davis, Linda C McCarthy

“…RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven…”
Get full text

Association Between Fluoroquinolone Use and Hospitalization With Aortic Aneurysm or Aortic Dissection by Brown, Jeremy P, Wing, Kevin, Leyrat, Clémence, Evans, Stephen J, Mansfield, Kathryn E, Wong, Angel Y S, Smeeth, Liam, Galwey, Nicholas W, Douglas, Ian J

“…Fluoroquinolone use has been associated with increased hospitalization with aortic aneurysm or dissection in noninterventional studies, but the reason for this…”
Get more information

Admixture analysis of age at onset in bipolar disorder by Tozzi, Federica, Manchia, Mirko, Galwey, Nicholas W, Severino, Giovanni, Del Zompo, Maria, Day, Richard, Matthews, Keith, Strauss, John, Kennedy, James L, McGuffin, Peter, Vincent, John B, Farmer, Anne, Muglia, Pierandrea

“…Abstract The aim of this study was to identify whether age at onset (AAO) identifies Bipolar Disorder (BD) subtypes, and to test whether the subgroups were…”
Get full text

A Genome-Wide Significant Linkage for Severe Depression on Chromosome 3: The Depression Network Study by Breen, Gerome, Webb, Bradley Todd, Butler, Amy W., van den Oord, Edwin J.C.G., Tozzi, Federica, Craddock, Nick, Gill, Mike, Korszun, Ania, Maier, Wolfgang, Middleton, Lefkos, Mors, Ole, Owen, Michael J., Cohen-Woods, Sarah, Perry, Julia, Galwey, Nicholas W., Upmanyu, Ruchi, Craig, Ian, Lewis, Cathryn M., Ng, Mandy, Brewster, Shyama, Preisig, Martin, Rietschel, Marcella, Jones, Lisa, Knight, Jo, Rice, John, Muglia, Pierandrea, Farmer, Anne E., McGuffin, Peter

“…Objective:The purpose of this study was to find loci for major depression via linkage analysis of a large sibling pair sample. Method:The authors conducted a…”
Get full text