Search Results - "Galvani, Elena"

The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival by Valpione, Sara, Mundra, Piyushkumar A., Galvani, Elena, Campana, Luca G., Lorigan, Paul, De Rosa, Francesco, Gupta, Avinash, Weightman, John, Mills, Sarah, Dhomen, Nathalie, Marais, Richard

“…Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor…”
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Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma by Girotti, Maria Romina, Gremel, Gabriela, Lee, Rebecca, Galvani, Elena, Rothwell, Dominic, Viros, Amaya, Mandal, Amit Kumar, Lim, Kok Haw Jonathan, Saturno, Grazia, Furney, Simon J, Baenke, Franziska, Pedersen, Malin, Rogan, Jane, Swan, Jacqueline, Smith, Matthew, Fusi, Alberto, Oudit, Deemesh, Dhomen, Nathalie, Brady, Ged, Lorigan, Paul, Dive, Caroline, Marais, Richard

“…Targeted therapies and immunotherapies have transformed melanoma care, extending median survival from ∼9 to over 25 months, but nevertheless most patients…”
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Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma by Galvani, Elena, Mundra, Piyushkumar A., Valpione, Sara, Garcia-Martinez, Pablo, Smith, Matthew, Greenall, Jonathan, Thakur, Rohit, Helmink, Beth, Andrews, Miles C., Boon, Louis, Chester, Christopher, Gremel, Gabriela, Hogan, Kate, Mandal, Amit, Zeng, Kang, Banyard, Antonia, Ashton, Garry, Cook, Martin, Lorigan, Paul, Wargo, Jennifer A., Dhomen, Nathalie, Marais, Richard

“…Although immune checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biological features of the durable responses initiated by…”
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Author Correction: The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival by Valpione, Sara, Mundra, Piyushkumar A., Galvani, Elena, Campana, Luca G., Lorigan, Paul, De Rosa, Francesco, Gupta, Avinash, Weightman, John, Mills, Sarah, Dhomen, Nathalie, Marais, Richard

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Effects of sorafenib on energy metabolism in breast cancer cells: role of AMPK–mTORC1 signaling by Fumarola, Claudia, Caffarra, Cristina, La Monica, Silvia, Galetti, Maricla, Alfieri, Roberta R., Cavazzoni, Andrea, Galvani, Elena, Generali, Daniele, Petronini, Pier Giorgio, Bonelli, Mara A.

“…In this study, we investigated the effects and the underlying molecular mechanisms of the multi-kinase inhibitor sorafenib in a panel of breast cancer cell…”
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Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones by Cavazzoni, Andrea, Bonelli, Mara A, Fumarola, Claudia, La Monica, Silvia, Airoud, Kinda, Bertoni, Ramona, Alfieri, Roberta R, Galetti, Maricla, Tramonti, Stefano, Galvani, Elena, Harris, Adrian L, Martin, Lesley-Ann, Andreis, Daniele, Bottini, Alberto, Generali, Daniele, Petronini, Pier Giorgio

“…Abstract Development of resistance to endocrine therapy is a clinical issue in estrogen receptor (ER)-positive breast cancer. Here we show that persistent…”
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Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides by Carmi, Caterina, Galvani, Elena, Vacondio, Federica, Rivara, Silvia, Lodola, Alessio, Russo, Simonetta, Aiello, Stefania, Bordi, Fabrizio, Costantino, Gabriele, Cavazzoni, Andrea, Alfieri, Roberta R, Ardizzoni, Andrea, Petronini, Pier Giorgio, Mor, Marco

“…Irreversible epidermal growth factor receptor (EGFR) inhibitors contain a reactive warhead which covalently interacts with a conserved cysteine residue in the…”
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Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification by La Monica, Silvia, Caffarra, Cristina, Saccani, Francesca, Galvani, Elena, Galetti, Maricla, Fumarola, Claudia, Bonelli, Mara, Cavazzoni, Andrea, Cretella, Daniele, Sirangelo, Rita, Gatti, Rita, Tiseo, Marcello, Ardizzoni, Andrea, Giovannetti, Elisa, Petronini, Pier Giorgio, Alfieri, Roberta R

“…Despite the initial response, all patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) eventually develop acquired…”
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Combined use of anti-ErbB monoclonal antibodies and erlotinib enhances antibody-dependent cellular cytotoxicity of wild-type erlotinib-sensitive NSCLC cell lines by Cavazzoni, Andrea, Alfieri, Roberta R, Cretella, Daniele, Saccani, Francesca, Ampollini, Luca, Galetti, Maricla, Quaini, Federico, Graiani, Gallia, Madeddu, Denise, Mozzoni, Paola, Galvani, Elena, La Monica, Silvia, Bonelli, Mara, Fumarola, Claudia, Mutti, Antonio, Carbognani, Paolo, Tiseo, Marcello, Barocelli, Elisabetta, Petronini, Pier Giorgio, Ardizzoni, Andrea

“…The epidermal growth factor receptor (EGFR) is an established target for anti-cancer treatment in different tumour types. Two different strategies have been…”
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Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines by Alfieri, Roberta R, Galetti, Maricla, Tramonti, Stefano, Andreoli, Roberta, Mozzoni, Paola, Cavazzoni, Andrea, Bonelli, Mara, Fumarola, Claudia, La Monica, Silvia, Galvani, Elena, De Palma, Giuseppe, Mutti, Antonio, Mor, Marco, Tiseo, Marcello, Mari, Ettore, Ardizzoni, Andrea, Petronini, Pier Giorgio

“…Gefitinib is a tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) especially effective in tumors with activating EGFR gene…”
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EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity by Galvani, Elena, Peters, Godefridus J, Giovannetti, Elisa

“…Conventional chemotherapeutic regimens have limited impact against most solid tumors and deal with significant toxicity. Over the last 10 years, novel…”
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Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer by Galvani, Elena, Alfieri, Roberta, Giovannetti, Elisa, Cavazzoni, Andrea, La Monica, Silvia, Galetti, Maricla, Fumarola, Claudia, Bonelli, Mara, Mor, Marco, Tiseo, Marcello, Peters, Godefridus J, Petronini, Pier Giorgio, Ardizzoni, Andrea

“…Conventional chemotherapeutic regimens have reached an efficacy plateau against most solid tumors and deal with significant toxicity. Recently, the goal of…”
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Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models by Sitnikova, Suzanne Isabelle, Munnings-Tomes, Sophie, Galvani, Elena, Kentner, Stacy, Mulgrew, Kathy, Rands, Chris, España Agustí, Judit, Zhang, Tianhui, Ilieva, Kristina M, Rosignoli, Guglielmo, Ghadially, Hormas, Robinson, Matthew J, Slidel, Tim, Wilkinson, Robert W, Dovedi, Simon J

“…BackgroundImmuno-oncology therapies are now part of the standard of care for cancer in many indications. However, durable objective responses remain limited to…”
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Pharmacogenetics of non-small cell lung cancer (NSCLC): time to "work it out"? by Galvani, Elena, Toffalorio, Francesca, Peters, Godefridus J, De Pas, Tommaso, Giovannetti, Elisa

“…The disappointing results in long-term survival of patients affected by non-small cell lung cancer (NSCLC) may be attributed, at least in part, to the lack of…”
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Molecular Mechanisms Underlying the Antitumor Activity of 3-Aminopropanamide Irreversible Inhibitors of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer by Galvani, Elena, Giovannetti, Elisa, Saccani, Francesca, Cavazzoni, Andrea, Leon, Leticia G, Dekker, Henk, Alfieri, Roberta, Carmi, Caterina, Mor, Marco, Ardizzoni, Andrea, Petronini, Pier Giorgio, Peters, Godefridus J

“…Abstract Overcoming the emergence of acquired resistance to clinically approved epidermal growth factor receptor (EGFR) inhibitors is a major challenge in the…”
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Thymidylate synthase inhibitors for thoracic tumors by Peters Godefridus J., Galvani Elena, Jansen Gerrit, Assaraf Yehuda, Giovannetti Elisa

“…Thymidylate synthase (TS) is a valid target for treatment of non-small cell lung cancer (NSCLC) and mesothelioma (MPM). The TS inhibitor pemetrexed (PMX) is…”
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Immune-awakening revealed by peripheral T cell dynamics after one cycle of immunotherapy by Valpione, Sara, Galvani, Elena, Tweedy, Joshua, Mundra, Piyushkumar A, Banyard, Antonia, Middlehurst, Philippa, Barry, Jeff, Mills, Sarah, Salih, Zena, Weightman, John, Gupta, Avinash, Gremel, Gabriela, Baenke, Franziska, Dhomen, Nathalie, Lorigan, Paul C, Marais, Richard

“…Our understanding of how checkpoint inhibitors (CPI) affect T cell evolution is incomplete, limiting our ability to achieve full clinical benefit from these…”
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Bayesian modeling for analyzing heterogeneous response in preclinical mouse tumor models by Zhang, Bairu, Magiera, Lukasz, Candido, Juliana, Muraeva, Olga, Coates Ulrichsen, Jane, Eyles, Jim, Galvani, Elena, Karp, Natasha A

“…In anticancer research, tumor growth measured in mouse models is important for assessing treatment efficacy for a treatment to progress to human clinical…”
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T cell immune awakening in response to immunotherapy is age-dependent by Salih, Zena, Banyard, Antonia, Tweedy, Joshua, Galvani, Elena, Middlehurst, Philippa, Mills, Sarah, Weightman, John, Gupta, Avinash, Lorigan, Paul C., Zhou, Cong, Dhomen, Nathalie, Valpione, Sara, Marais, Richard

“…Precision immuno-oncology approaches are needed to improve cancer care. We recently demonstrated that in patients with metastatic melanoma, an increase of…”
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Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models by Kaistha, Brajesh P, Kar, Gozde, Dannhorn, Andreas, Watkins, Amanda, Opoku-Ansah, Grace, Ilieva, Kristina, Mullins, Stefanie, Anderton, Judith, Galvani, Elena, Garcon, Fabien, Lapointe, Jean-Martin, Brown, Lee, Hair, James, Slidel, Tim, Luheshi, Nadia, Ryan, Kelli, Hardaker, Elizabeth, Dovedi, Simon, Kumar, Rakesh, Wilkinson, Robert W, Hammond, Scott A, Eyles, Jim

“…CD73 is a cell surface 5'nucleotidase (NT5E) and key node in the catabolic process generating immunosuppressive adenosine in cancer. Using a murine monoclonal…”
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