SARS‐CoV‐2, COVID‐19, skin and immunology – What do we know so far?

The pandemic condition coronavirus disease (COVID‐19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can take asymptomatic, mild, moderate, and severe courses. COVID‐19 affects primarily the respiratory airways leading to dry cough, fever, myalgia, headache, fatig...

Full description

Saved in:

Bibliographic Details
Published in:	Allergy (Copenhagen) Vol. 76; no. 3; pp. 698 - 713
Main Authors:	Novak, Natalijia, Peng, Wenming, Naegeli, Mirjam C., Galvan, Christina, Kolm‐Djamei, Isabel, Brüggen, Charlotte, Cabanillas, Beatriz, Schmid‐Grendelmeier, Peter, Catala, Alba
Format:	Journal Article
Language:	English
Published:	Denmark Blackwell Publishing Ltd 01-03-2021 John Wiley and Sons Inc
Subjects:	allergy Angiotensin-Converting Enzyme 2 - analysis Coronaviridae Coronaviruses Cough COVID-19 COVID-19 - complications COVID-19 - immunology COVID-19 - pathology COVID-19 - transmission Diarrhea drug hypersensitivity Female Fever Humans Immunology Male Myalgia Pandemics Respiratory failure Review Reviews SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 skin Skin - pathology Skin diseases Skin Diseases - etiology Skin Diseases - pathology Skin lesions Vascular system Vasculitis virus skin allergy drug hypersensitivity virus
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The pandemic condition coronavirus disease (COVID‐19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can take asymptomatic, mild, moderate, and severe courses. COVID‐19 affects primarily the respiratory airways leading to dry cough, fever, myalgia, headache, fatigue, and diarrhea and can end up in interstitial pneumonia and severe respiratory failure. Reports about the manifestation of various skin lesions and lesions of the vascular system in some subgroups of SARS‐CoV‐2‐positive patients as such features outside the respiratory sphere, are rapidly emerging. Vesicular, urticarial, and maculopapular eruptions and livedo, necrosis, and other vasculitis forms have been reported most frequently in association with SARS‐CoV‐2 infection. In order to update information gained, we provide a systematic overview of the skin lesions described in COVID‐19 patients, discuss potential causative factors, and describe differential diagnostic evaluations. Moreover, we summarize current knowledge about immunologic, clinical, and histologic features of virus‐ and drug‐induced lesions of the skin and changes to the vascular system in order to transfer this knowledge to potential mechanisms induced by SARS‐CoV‐2.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Novak Natalijia, Peng Wenming, Mirjam C. Naegeli, Christina Galvan contributed equally to this work.
ISSN:	0105-4538 1398-9995
DOI:	10.1111/all.14498