Search Results - "Galván, José A"

Co-expression of cytokeratin and vimentin in colorectal cancer highlights a subset of tumor buds and an atypical cancer-associated stroma by Meyer, Sara N., Galván, José A., Zahnd, Stefan, Sokol, Lena, Dawson, Heather, Lugli, Alessandro, Zlobec, Inti

“…Tumor buds in colorectal cancer are hypothesized to undergo a (partial) epithelial-mesenchymal transition (EMT). If so, cytokeratin (CK) and vimentin (VIM)…”
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Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion by Zeng, Qiqun, Saghafinia, Sadegh, Chryplewicz, Agnieszka, Fournier, Nadine, Christe, Lucine, Xie, Yu-Qing, Guillot, Jeremy, Yucel, Simge, Li, Pumin, Galván, José A., Karamitopoulou, Eva, Zlobec, Inti, Ataca, Dalya, Gallean, Fleuriane, Zhang, Peng, Rodriguez-Calero, José Antonio, Rubin, Mark, Tichet, Mélanie, Homicsko, Krisztian, Hanahan, Douglas

“…Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that…”
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Stromal PD-1/PD-L1 Expression Predicts Outcome in Colon Cancer Patients by Wyss, Jacqueline, Dislich, Bastian, Koelzer, Viktor H., Galván, José A., Dawson, Heather, Hädrich, Marion, Inderbitzin, Daniel, Lugli, Alessandro, Zlobec, Inti, Berger, Martin D.

“…The programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) axis plays an important role in controlling immune suppression by down-regulating T…”
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Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome by Marti, Nesa, Galván, José A., Pandey, Amit V., Trippel, Mafalda, Tapia, Coya, Müller, Michel, Perren, Aurel, Flück, Christa E.

“…Recently, dihydrotestosterone biosynthesis through the backdoor pathway has been implicated for the human testis in addition to the classic pathway for…”
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Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer by Schläfli, Anna M, Adams, Olivia, Galván, José A, Gugger, Mathias, Savic, Spasenija, Bubendorf, Lukas, Schmid, Ralph A, Becker, Karl-Friedrich, Tschan, Mario P, Langer, Rupert, Berezowska, Sabina

“…Autophagy is a cellular degrading process that promotes tumor cell survival or cell death in cancer, depending on the progress of oncogenesis. Protein light…”
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Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis by Gander-Bui, Hang Thi Thuy, Schläfli, Joëlle, Baumgartner, Johanna, Walthert, Sabrina, Genitsch, Vera, van Geest, Geert, Galván, José A, Cardozo, Carmen, Graham Martinez, Cristina, Grans, Mona, Muth, Sabine, Bruggmann, Rémy, Probst, Hans Christian, Gabay, Cem, Freigang, Stefan

“…Invasive fungal infections are associated with high mortality rates, and the lack of efficient treatment options emphasizes an urgency to identify underlying…”
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GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth by Li, Leanne, Zeng, Qiqun, Bhutkar, Arjun, Galván, José A., Karamitopoulou, Eva, Noordermeer, Daan, Peng, Mei-Wen, Piersigilli, Alessandra, Perren, Aurel, Zlobec, Inti, Robinson, Hugh, Iruela-Arispe, M. Luisa, Hanahan, Douglas

“…Genetic linkage analysis previously suggested that GKAP, a scaffold protein of the N-methyl-D-aspartate receptor (NMDAR), was a potential modifier of invasion…”
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TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells by Kappel, Sven, Stokłosa, Paulina, Hauert, Barbara, Ross‐Kaschitza, Daniela, Borgström, Anna, Baur, Roland, Galván, José A., Zlobec, Inti, Peinelt, Christine

“…Transient receptor potential melastatin‐4 channel (TRPM4) dysregulation contributes to heart conditions, immune diseases, and cervical and prostate cancer. Up…”
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Overexpression of COL11A1 by cancer-associated fibroblasts: clinical relevance of a stromal marker in pancreatic cancer by García-Pravia, Carmen, Galván, José A, Gutiérrez-Corral, Natalia, Solar-García, Lorena, García-Pérez, Eva, García-Ocaña, Marcos, Del Amo-Iribarren, Jokin, Menéndez-Rodríguez, Primitiva, García-García, Juan, de Los Toyos, Juan R, Simón-Buela, Laureano, Barneo, Luis

“…The collagen11A1 (COL11A1) gene is overexpressed in pancreatic cancer. The expression of COL11A1 protein could be involved in desmoplastic events in pancreatic…”
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A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancer by Noti, Luca, Galván, José A, Dawson, Heather, Lugli, Alessandro, Kirsch, Richard, Assarzadegan, Naziheh, Messenger, David, Krebs, Philippe, Berger, Martin D, Zlobec, Inti

“…Background Previous assessments of peritumoral inflammatory infiltrate in colorectal cancer (CRC) have focused on the role of CD8.sup.+ T lymphocytes. We…”
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Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma by Ferguson, L. Paige, Gatchalian, Jovylyn, McDermott, Matthew L., Nakamura, Mari, Chambers, Kendall, Rajbhandari, Nirakar, Lytle, Nikki K., Rosenthal, Sara Brin, Hamilton, Michael, Albini, Sonia, Wartenberg, Martin, Zlobec, Inti, Galván, José A., Karamitopoulou, Eva, Vavinskaya, Vera, Wascher, Alexis, Lowy, Andrew M., Schürch, Christian M., Puri, Pier Lorenzo, Bruneau, Benoit G., Hargreaves, Diana C., Reya, Tannishtha

“…Pancreatic cancer is characterized by extensive resistance to conventional therapies, making clinical management a challenge. Here we map the epigenetic…”
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Minor intron splicing is critical for survival of lethal prostate cancer by Augspach, Anke, Drake, Kyle D., Roma, Luca, Qian, Ellen, Lee, Se Ri, Clarke, Declan, Kumar, Sushant, Jaquet, Muriel, Gallon, John, Bolis, Marco, Triscott, Joanna, Galván, José A., Chen, Yu, Thalmann, George N., Kruithof-de Julio, Marianna, Theurillat, Jean-Philippe P., Wuchty, Stefan, Gerstein, Mark, Piscuoglio, Salvatore, Kanadia, Rahul N., Rubin, Mark A.

“…The evolutionarily conserved minor spliceosome (MiS) is required for protein expression of ∼714 minor intron-containing genes (MIGs) crucial for cell-cycle…”
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Immunohistochemical analysis of the expression of cancer-associated fibroblast markers in esophageal cancer with and without neoadjuvant therapy by Galván, José A., Wiprächtiger, Julia, Slotta-Huspenina, Julia, Feith, Marcus, Ott, Katja, Kröll, Dino, Seiler, Christian A., Langer, Rupert

“…Esophageal carcinoma (EC) is one of the most aggressive human malignancies with high rates of resistance to conventional anticancer treatment…”
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TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer by Galván, José A, Helbling, Melina, Koelzer, Viktor H, Tschan, Mario P, Berger, Martin D, Hädrich, Marion, Schnüriger, Beat, Karamitopoulou, Eva, Dawson, Heather, Inderbitzin, Daniel, Lugli, Alessandro, Zlobec, Inti

“…Tumor budding in colorectal cancer is likened to an epithelial-mesenchymal transition (EMT) characterized predominantly by loss of E-cadherin and up-regulation…”
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COL11A1/(pro)collagen 11A1 expression is a remarkable biomarker of human invasive carcinoma-associated stromal cells and carcinoma progression by Vázquez-Villa, Fernando, García-Ocaña, Marcos, Galván, José A., García-Martínez, Jorge, García-Pravia, Carmen, Menéndez-Rodríguez, Primitiva, Rey, Carmen González-del, Barneo-Serra, Luis, de los Toyos, Juan R.

“…The COL11A1 human gene codes for the α1 chain of procollagen 11A1 and mature collagen 11A1, an extracellular minor fibrillar collagen. Under regular…”
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Tumour budding and CD8+ T cells: ‘attackers’ and ‘defenders’ in rectal cancer with and without neoadjuvant chemoradiotherapy by Georges, Nadine D F, Oberli, Beatrice, Rau, Tilman T, Galván, José A, Nagtegaal, Iris D, Dawson, Heather, Blank, Annika, Kohler, Andreas, Lugli, Alessandro, Zlobec, Inti

“…Aim Tumour budding (‘attacker’) and CD8+ T cells (‘defender’) are recognised as important parameters for risk stratification in colon cancers and, combined,…”
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CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway by Graule, Janina, Uth, Kristin, Fischer, Elia, Centeno, Irene, Galván, José A, Eichmann, Micha, Rau, Tilman T, Langer, Rupert, Dawson, Heather, Nitsche, Ulrich, Traeger, Peter, Berger, Martin D, Schnüriger, Beat, Hädrich, Marion, Studer, Peter, Inderbitzin, Daniel, Lugli, Alessandro, Tschan, Mario P, Zlobec, Inti

“…In colorectal cancer, CDX2 expression is lost in approximately 20% of cases and associated with poor outcome. Here, we aim to validate the clinical impact of…”
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Tyrosine kinase receptor B (TrkB) expression in colorectal cancers highlights anoikis resistance as a survival mechanism of tumour budding cells by Dawson, Heather, Grundmann, Sandra, Koelzer, Viktor H, Galván, José A, Kirsch, Richard, Karamitopoulou, Eva, Lugli, Alessandro, Inderbitzin, Daniel, Zlobec, Inti

“…Aims Tumour buds in colorectal cancer represent an aggressive subgroup of non‐proliferating and non‐apoptotic tumour cells. We hypothesize that the survival of…”
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PTEN alterations of the stromal cells characterise an aggressive subpopulation of pancreatic cancer with enhanced metastatic potential by Wartenberg, Martin, Centeno, Irene, Haemmig, Stefan, Vassella, Erik, Zlobec, Inti, Galván, José A, Neuenschwander, Maja, Schlup, Cornelia, Gloor, Beat, Lugli, Alessandro, Perren, Aurel, Karamitopoulou, Eva

“…Abstract Background Neoplastic stroma is believed to influence tumour progression. Here, we examine phosphatase and tensin homolog deleted on chromosome ten…”
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Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia by Aguirre, Alina, López-Alonso, Inés, González-López, Adrián, Amado-Rodríguez, Laura, Batalla-Solís, Estefanía, Astudillo, Aurora, Blázquez-Prieto, Jorge, Fernández, Alvaro F., Galván, José A., dos Santos, Claudia C., Albaiceta, Guillermo M.

“…Autophagy has emerged as a key regulator of the inflammatory response. To examine the role of autophagy in the development of organ dysfunction during…”
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