Search Results - "Galter, Dagmar"
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Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson’s and Alzheimer’s disease
Published in Cell and tissue research (01-09-2017)“…Myeloperoxidase (MPO) is a key enzyme in inflammatory and degenerative processes, although conflicting reports have been presented concerning its expression in…”
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Modulation of the endoplasmic reticulum–mitochondria interface in Alzheimer’s disease and related models
Published in Proceedings of the National Academy of Sciences - PNAS (07-05-2013)“…It is well-established that subcompartments of endoplasmic reticulum (ER) are in physical contact with the mitochondria. These lipid raft-like regions of ER…”
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Parkinson's disease: genetic versus toxin-induced rodent models
Published in The FEBS journal (01-04-2008)“…Parkinson's disease (PD), a common progressive neurodegenerative disorder, is characterized by degeneration of dopamine neurons in the substantia nigra and…”
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PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
Published in Nature medicine (01-01-2012)“…The cytokine PDGF has multiple effects on the vasculature and influences tumor growth and progression. Yuan Xue et al . uncover a new role for PDGF as a…”
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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2
Published in PloS one (06-04-2011)“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to…”
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Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
Published in Proceedings of the National Academy of Sciences - PNAS (23-01-2007)“…Mitochondrial dysfunction is implicated in the pathophysiology of Parkinson's disease (PD), a common age-associated neurodegenerative disease characterized by…”
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Strong Association Between Glucocerebrosidase Mutations and Parkinson’s Disease in Sweden
Published in Neurobiology of aging (01-09-2016)“…Abstract Several genetic studies have demonstrated an association between mutations in glucocerebrosidase ( GBA ), originally implicated in Gaucher’s disease,…”
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Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration
Published in Neurobiology of disease (01-11-2014)“…Abstract Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and…”
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PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
Published in Cancer cell (01-10-2004)“…Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay…”
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10
VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation
Published in Proceedings of the National Academy of Sciences - PNAS (05-01-2010)“…The "One neuron-one neurotransmitter" concept has been challenged frequently during the last three decades, and the coexistence of neurotransmitters in…”
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Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
Published in Cancer research (Chicago, Ill.) (15-10-2005)“…Metastases are commonly found in the lymphatic system. The molecular mechanism of lymphatic metastasis is, however, poorly understood. Here we report that…”
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12
MAGI1 Copy Number Variation in Bipolar Affective Disorder and Schizophrenia
Published in Biological psychiatry (1969) (15-05-2012)“…Background Bipolar affective disorder (BPAD) and schizophrenia (SZ) are devastating psychiatric disorders that each affect about 1% of the population…”
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No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts
Published in PloS one (01-04-2015)“…Mutations within the LRRK2 gene have been identified in Parkinson's disease (PD) patients and have been implicated in the dysfunction of several cellular…”
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ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia
Published in Neurobiology of disease (01-12-2003)“…Dopamine (DA) neurons degenerate in Parkinson's disease and dopamine neurotransmission may be affected in psychotic states seen in schizophrenia. Understanding…”
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Genetic Variations and mRNA Expression of NRF2 in Parkinson’s Disease
Published in Parkinson's disease (01-01-2017)“…Nuclear factor erythroid 2-like 2 (NRF2) encodes a transcription factor regulating mechanisms of cellular protection and is activated by oxidative stress. NRF2…”
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Chronic A2A antagonist treatment alleviates parkinsonian locomotor deficiency in MitoPark mice
Published in Neurobiology of disease (01-11-2010)“…Abstract Adenosine A2A receptor (A2A R) antagonists are being investigated as promising treatment strategy for Parkinson's disease (PD). To test whether A2A R…”
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Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease
Published in Brain research (12-12-2007)“…Abstract Mutations in PINK1 (PTEN-induced putative kinase 1) are causal for early onset recessive parkinsonism in humans, characterized by damage to the…”
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Adh1 and Adh1/ 4 knockout mice as possible rodent models for presymptomatic Parkinson's disease
Published in Behavioural brain research (01-02-2012)“…► Adh1−/− and Adh1/ 4−/− mice have higher spontaneous activity compared to WT mice. ► Apomorphine increase locomotor activity in Adh1−/− and Adh1/ 4−/− mice. ►…”
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High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract
Published in The FEBS journal (01-03-2007)“…Parkinson's disease (PD) is a heterogeneous movement disorder characterized by progressive degeneration of dopamine neurons in substantia nigra. We have…”
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Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease
Published in Parkinson's disease (01-01-2010)“…Genes important for mitochondrial function have been implicated in Parkinson's disease (PD). Mitochondrial translation initiation factor 3 (MTIF3) is a nuclear…”
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