Search Results - "Galter, D."
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Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease
Published in Neuroscience (18-03-2008)“…Abstract Mutations in leucine-rich repeat kinase 2 ( LRRK2 ) constitute the most common known cause of Parkinson’s disease (PD), accounting for both familial…”
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Strong Association Between Glucocerebrosidase Mutations and Parkinson’s Disease in Sweden
Published in Neurobiology of aging (01-09-2016)“…Abstract Several genetic studies have demonstrated an association between mutations in glucocerebrosidase ( GBA ), originally implicated in Gaucher’s disease,…”
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Neurodegenerative phenotypes in an A53T -synuclein transgenic mouse model are independent of LRRK2
Published in Human molecular genetics (01-06-2012)“…Mutations in the genes encoding LRRK2 and alpha -synuclein cause autosomal dominant forms of familial Parkinson's disease (PD). Fibrillar forms of alpha…”
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Chronic L‐DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice
Published in Genes, brain and behavior (01-03-2015)“…Dopamine (DA) replacement therapy continues to be the gold standard treatment for Parkinson's disease (PD), as it improves key motor symptoms including…”
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MitoPark mice mirror the slow progression of key symptoms and L‐DOPA response in Parkinson's disease
Published in Genes, brain and behavior (01-03-2010)“…The MitoPark mouse, in which the mitochondrial transcription factor Tfam is selectively removed in midbrain dopamine (DA) neurons, is a genetic model for…”
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Chronic L‐DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice
Published in GENES BRAIN AND BEHAVIOR (01-06-2015)Get full text
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Association of a protective paraoxonase 1 (PON1) polymorphism in Parkinson's disease
Published in Neuroscience letters (26-07-2012)“…► Association with a PON1 promoter polymorphism (rs854571) and Parkinson's disease. ► Minor rs854571 allele more common among controls, suggesting protective…”
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Age-associated mosaic respiratory chain deficiency causes trans-neuronal degeneration
Published in Human molecular genetics (15-05-2008)“…Heteroplasmic mitochondrial DNA (mtDNA) mutations (mutations present only in a subset of cellular mtDNA copies) arise de novo during the normal ageing process…”
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Growth/Differentiation Factor-15/Macrophage Inhibitory Cytokine-1 Is a Novel Trophic Factor for Midbrain Dopaminergic Neurons In Vivo
Published in The Journal of neuroscience (01-12-2000)“…Transforming growth factor-betas (TGF-betas) constitute an expanding family of multifunctional cytokines with prominent roles in development, cell…”
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Regulation of the transmitter phenotype of rostral and caudal groups of cultured serotonergic raphe neurons
Published in Neuroscience (1999)“…We have studied the regulation of survival and serotonergic markers by neurotrophins and several trophically active cytokines in neurons cultured from the…”
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Comparison of Three Hypothermic Target Temperatures for the Treatment of Hypoxic Ischemia: mRNA Level Responses of Eight Genes in the Piglet Brain
Published in Translational stroke research (01-04-2013)“…Hypothermia can reduce neurodevelopmental disabilities in asphyxiated newborn infants. However, the optimal cooling temperature for neuroprotection is not well…”
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P.2.035 Alcohol dehydrogenase 4 knock-out mice as a model of dopamine-system related dysfunction
Published in European neuropsychopharmacology (2010)Get full text
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The Mesopotamian God Enki/Ea
Published in Religion compass (01-03-2015)“…The traditions and beliefs about the Mesopotamian deity Enki/Ea – the god of water, wisdom, magic, and creation – formed a major part of the Sumerian and…”
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Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins
Published in The European journal of neuroscience (01-07-1999)“…Bone morphogenetic proteins (BMPs), growth and differentiation factor 5 (GDF5) and glial cell line‐derived neurotrophic factor (GDNF) are members of the…”
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Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson’s and Alzheimer’s disease
Published in Cell and tissue research (01-09-2017)“…Myeloperoxidase (MPO) is a key enzyme in inflammatory and degenerative processes, although conflicting reports have been presented concerning its expression in…”
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Modulation of the endoplasmic reticulum–mitochondria interface in Alzheimer’s disease and related models
Published in Proceedings of the National Academy of Sciences - PNAS (07-05-2013)“…It is well-established that subcompartments of endoplasmic reticulum (ER) are in physical contact with the mitochondria. These lipid raft-like regions of ER…”
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Role of cysteine and glutathione in signal transduction, immunopathology and cachexia
Published in BioFactors (Oxford) (1998)“…Abnormally low plasma cystine levels have been found in the late asymptomatic stage of HIV infection and several other diseases associated with progressive…”
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Parkinson's disease: genetic versus toxin-induced rodent models
Published in The FEBS journal (01-04-2008)“…Parkinson's disease (PD), a common progressive neurodegenerative disorder, is characterized by degeneration of dopamine neurons in the substantia nigra and…”
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PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
Published in Nature medicine (01-01-2012)“…The cytokine PDGF has multiple effects on the vasculature and influences tumor growth and progression. Yuan Xue et al . uncover a new role for PDGF as a…”
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