Search Results - "Galpern, W R"

Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data by Chen, Y C, Galpern, W R, Brownell, A L, Matthews, R T, Bogdanov, M, Isacson, O, Keltner, J R, Beal, M F, Rosen, B R, Jenkins, B G

“…The metabolic activation resulting from direct dopaminergic stimulation can be detected using auto-radiography, positron emission tomography (PET) or,…”
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Xenotransplantation of Porcine Fetal Ventral Mesencephalon in a Rat Model of Parkinson's Disease: Functional Recovery and Graft Morphology by Galpern, Wendy R., Burns, Lindsay H., Deacon, Terrence W., Dinsmore, Jonathan, Isacson, Ole

“…Neurotransplantation of human fetal dopamine (DA) neurons is currently being investigated as a therapeutic modality for Parkinson's disease (PD). However, the…”
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Implanted Fibroblasts Genetically Engineered to Produce Brain-Derived Neurotrophic Factor Prevent 1-Methyl-4-Phenylpyridinium Toxicity to Dopaminergic Neurons in the Rat by Frim, David M., Uhler, Tara A., Galpern, Wendy R., Beal, M. Flint, Breakefield, Xandra O., Isacson, Ole

“…The trophism of brain-derived neurotrophic factor (BDNF) for dopaminergic cells in culture has led to significant interest in the role of BDNF in the etiology…”
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Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain by Miller, L G, Galpern, W R, Dunlap, K, Dinarello, C A, Turner, T J

“…Interleukin-1 (IL-1), a cytokine involved in the acute phase reaction to injury and infection, has multiple effects in the central nervous system, including…”
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NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease by Galpern, W R, Matthews, R T, Beal, M F, Isacson, O

“…Nerve growth factor (NGF)-secreting fibroblasts are able to protect against the Huntington-like striatal neurodegeneration induced by the mitochondrial toxin…”
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Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration by Galpern, W R, Frim, D M, Tatter, S B, Altar, C A, Beal, M F, Isacson, O

“…Brain-derived neurotrophic factor (BDNF) promotes the survival of fetal mesencephalic dopaminergic cells and protects dopaminergic neurons against the toxicity…”
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Chronic benzodiazepine administration. VI. A partial agonist produces behavioral effects without tolerance or receptor alterations by Miller, L G, Galpern, W R, Greenblatt, D J, Lumpkin, M, Shader, R I

“…Chronic benzodiazepine administration has been reported to lead to behavioral tolerance and, in some cases, downregulation of gamma-aminobutyric acid A…”
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Chronic benzodiazepine administration. VIII. Receptor upregulation produced by chronic exposure to the inverse agonist FG-7142 by Pritchard, G A, Galpern, W R, Lumpkin, M, Miller, L G

“…Treatment with benzodiazepine agonists is associated with the development of behavioral tolerance and receptor downregulation, whereas antagonist…”
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Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres by Isacson, Ole, Deacon, Terrence W, Pakzaban, Peyman, Galpern, Wendy R, Dinsmore, Jonathan, Burns, Lindsay H

“…Clinical trials are under way using fetal cells to repair damaged neuronal circuitry. However, little is known about how transplanted immature neurons can grow…”
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Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK11195 attenuates chronic effects of lorazepam by Miller, L G, Galpern, W R, Byrnes, J J, Greenblatt, D J, Shader, R I

“…Chronic administration of benzodiazepine active at the tau-aminobutyric acidA receptor ("central" benzodiazepine sites) is associated with behavioral tolerance…”
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Prenatal exposure to benzodiazepine--I. Prenatal exposure to lorazepam in mice alters open-field activity and GABAA receptor function by Chesley, S, Lumpkin, M, Schatzki, A, Galpern, W R, Greenblatt, D J, Shader, R I, Miller, L G

“…Prenatal exposure to benzodiazepines may lead to developmental abnormalities in humans and animals. To assess the behavioral and neurochemical effects of such…”
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Benzodiazepine receptor binding of benzodiazepine hypnotics: receptor and ligand specificity by Miller, L G, Galpern, W R, Byrnes, J J, Greenblatt, D J

“…Benzodiazepine (BDZ) hypnotics bind at a specific receptor located on postsynaptic neurons. Some data support specificity of binding for several hypnotics to…”
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Differential effects of chronic lorazepam and alprazolam on benzodiazepine binding and GABAA‐receptor function by Galpern, Wendy R., Miller, Lawrence G., Greenblatt, David J., Shader, Richard I.

“…1 Chronic benzodiazepine administration has been associated with tolerance and with downregulation of γ‐aminobutyric acidA (GABAA)‐receptor binding and…”
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Effects of striatal excitotoxicity on huntingtin-like immunoreactivity by Tatter, S B, Galpern, W R, Hoogeveen, A T, Isacson, O

“…The relationship between the specific neuronal loss observed in Huntington's disease and the mutation in the IT15 gene responsible for this disease remains…”
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Clinimetric testing of the comprehensive cervical dystonia rating scale by Comella, Cynthia L., Perlmutter, Joel S., Jinnah, Hyder A., Waliczek, Tracy A., Rosen, Ami R., Galpern, Wendy R., Adler, Charles A., Barbano, Richard L., Factor, Stewart A., Goetz, Christopher G., Jankovic, Joseph, Reich, Stephen G., Rodriguez, Ramon L., Severt, William L., Zurowski, Mateusz, Fox, Susan H., Stebbins, Glenn T.

“…ABSTRACT Introduction The aim of this study was to test the clinimetric properties of the Comprehensive Cervical Dystonia Rating Scale. This is a modular scale…”
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Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer’s Disease by Galpern, Wendy R., Triana-Baltzer, G., Li, L., Van Kolen, K., Timmers, M., Haeverans, K., Janssens, L., Kolb, H., Nandy, P., Aida, K., Shimizu, H., Mercken, M., Sun, H.

“…Background JNJ-63733657 (posdinemab) is a humanized IgG1/kappa monoclonal anti-phospho tau antibody that binds with high affinity to phosphorylated amino acid…”
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Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging by Miller, L G, Lumpkin, M, Galpern, W R, Greenblatt, D J, Shader, R I

“…The irreversible protein-modifying reagent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was used to investigate binding site characteristics on the…”
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Chronic benzodiazepine administration. IX. Attenuation of alprazolam discontinuation effects by carbamazepine by Galpern, W R, Miller, L G, Greenblatt, D J, Szabo, G K, Browne, T R, Shader, R I

“…Clinical studies suggest that carbamazepine may attenuate effects of alprazolam discontinuation. Since discontinuation of chronic alprazolam in a mouse model…”
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Interface between tauopathies and synucleinopathies: A tale of two proteins by Galpern, Wendy R., Lang, Anthony E.

“…Neurodegenerative diseases are often classified based on the abnormal accumulation of synuclein or tau. Traditionally, these disorders have been viewed as…”
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Differential effects of chronic lorazepam and alprazolam on benzodiazepine binding and GABA A ‐receptor function by Galpern, Wendy R., Miller, Lawrence G., Greenblatt, David J., Shader, Richard I.

“…Chronic benzodiazepine administration has been associated with tolerance and with downregulation of γ‐aminobutyric acid A (GABA A )‐receptor binding and…”
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