Search Results - "Galper, Jonas B"

Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3 by Qin, Zhexue, Bagley, Jessamyn, Sukhova, Galina, Baur, Wendy E, Park, Ho-Jin, Beasley, Debbie, Libby, Peter, Zhang, Yali, Galper, Jonas B

“…Abstract Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65 years of age. Male apolipoprotein E knockout (ApoE−/− )…”
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Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling by Bhedi, Chinmayee D., Nasirova, Sabina, Toksoz, Deniz, Warburton, Rod R., Morine, Kevin J., Kapur, Navin K., Galper, Jonas B., Preston, Ioana R., Hill, Nicholas S., Fanburg, Barry L., Penumatsa, Krishna C.

“…The pathophysiology of pulmonary hypertension (PH) and heart failure (HF) includes fibrogenic remodeling associated with the loss of pulmonary arterial (PA)…”
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Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice by Higashimori, Mie, Tatro, Jeffrey B, Moore, Kathryn J, Mendelsohn, Michael E, Galper, Jonas B, Beasley, Debbie

“…OBJECTIVE—Atherosclerosis encompasses a conspicuously maladaptive inflammatory response that might involve innate immunity. Here, we compared the role of…”
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Targeted disruption of glycogen synthase kinase-3β in cardiomyocytes attenuates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice by Zhang, Yali, Welzig, Charles M, Haburcak, Marian, Wang, Bo, Aronovitz, Mark, Blanton, Robert M, Park, Ho-Jin, Force, Thomas, Noujaim, Sami, Galper, Jonas B

“…Type 1 diabetic Akita mice develop severe cardiac parasympathetic dysfunction that we have previously demonstrated is due at least in part to an abnormality in…”
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Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin by Rajab, Mohammad, Jin, Hongwei, Welzig, Charles M, Albano, Alfred, Aronovitz, Mark, Zhang, Yali, Park, Ho-Jin, Link, Mark S, Noujaim, Sami F, Galper, Jonas B

“…Although a reduction in the high-frequency (HF) component of heart rate variability (HRV) is a major complication of diabetes and a risk factor for sudden…”
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Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP by Park, Ho-Jin, Georgescu, Serban P, Du, Chuang, Madias, Christopher, Aronovitz, Mark J, Welzig, C Michael, Wang, Bo, Begley, Ulrike, Zhang, Yali, Blaustein, Robert O, Patten, Richard D, Karas, Richard H, Van Tol, Herbert H, Osborne, Timothy F, Shimano, Hitoshi, Liao, Ronglih, Link, Mark S, Galper, Jonas B

“…Parasympathetic stimulation of the heart, which provides protection from arrhythmias and sudden death, involves activation of the G protein-coupled inward…”
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Differential Effects of Statins ( Pravastatin or Simvastatin ) on Ventricular Ectopic Complexes: Gαi2 , a Possible Molecular Marker for Ventricular Irritability by Welzig, C. Michael, MD, PhD, Park, Ho-Jin, PhD, Naggar, Jack, BA, Confalone, Deborah, RN, MS, Rhofiry, Joanne, Shea, Julie, MS, RNCS, Karas, Richard H., MD, PhD, Estes, N.A. Mark, MD, Galper, Jonas B., MD, PhD

“…Retrospective studies suggest that statins might exert an antiarrhythmic effect on the heart. The mechanism of this effect is unclear. Parasympathetic…”
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Simvastatin Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-Knockout Mice: Possible Role of ERK by YALI ZHANG, NAGGAR, Jack C, WELZIG, C. Michael, BEASLEY, Debbie, MOULTON, Karen S, PARK, Ho-Jin, GALPER, Jonas B

“…Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost 10% of the population over age 65. Generation of AAAs by infusion of angiotensin…”
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Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis by Park, Ho-Jin, Zhang, Yali, Georgescu, Serban P, Johnson, Kristin L, Kong, Dequon, Galper, Jonas B

“…Human umbilical vein endothelial cells (HUVECs) have played a major role as a model system for the study of the regulation of endothelial cell function and the…”
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QRS/T-wave and calcium alternans in a type I diabetic mouse model for spontaneous postmyocardial infarction ventricular tachycardia: A mechanism for the antiarrhythmic effect of statins by Jin, Hongwei, Welzig, Charles M, Aronovitz, Mark, Noubary, Farzad, Blanton, Robert, Wang, Bo, Rajab, Mohammad, Albano, Alfred, Link, Mark S, Noujaim, Sami F, Park, Ho-Jin, Galper, Jonas B

“…The incidence of sudden arrhythmic death is markedly increased in diabetics. The purpose of this study was to develop a mouse model for postmyocardial…”
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3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Interfere With Angiogenesis by Inhibiting the Geranylgeranylation of RhoA by Park, Ho-Jin, Kong, Dequan, Iruela-Arispe, Luisa, Begley, Ulrike, Tang, Dongjiang, Galper, Jonas B

“…Angiogenesis is implicated in the pathogenesis of cancer, rheumatoid arthritis, and atherosclerosis and in the treatment of coronary artery and peripheral…”
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Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice by YALI ZHANG, WELZIG, Charles M, PARK, Ho-Jin, GALPER, Jonas B, PICARD, Kristen L, CHUANG DU, BO WANG, PAN, Jen Q, KYRIAKIS, John M, ARONOVITZ, Mark J, CLAYCOMB, William C, BLANTON, Robert M

“…Decreased heart rate variability (HRV) is a major risk factor for sudden death and cardiovascular disease. We previously demonstrated that parasympathetic…”
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Targeted disruption of glycogen synthase kinase-3β in the heart attenuates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice by Welzig, Charles M, Zhang, Yali, Haburcak, Marian, Wang, Bo, Aronovitz, Mark, Park, Ho-Jin, Noujaim, Sami, Galper, Jonas B

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QRS/T-Wave and Calcium Alternans in a Type I Diabetic Mouse Model for Spontaneous Post Myocardial Infarction Ventricular Tachycardia: A Mechanism for the Antiarrhythmic Effect of Statins by Jin, Hongwei, PhD, Welzig, Charles M., MD, Aronovitz, Mark, BA, Noubary, Farzad, PhD, Blanton, Robert, MD, Wang, Bo, MD, Rajab, Mohammad, MD, Albano, Alfred, MD, Link, Mark S., MD, FHRS, Noujaim, Sami F., PhD, Park, Ho-Jin, PhD, Galper, Jonas B., MD-PhD

“…Background The incidence of sudden arrhythmic death is markedly increased in diabetics. Objective Develop a mouse model for Post MI VT in the diabetic heart…”
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Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice by Park, Ho-Jin, Zhang, Yali, Du, Chuang, Welzig, C Michael, Madias, Christopher, Aronovitz, Mark J, Georgescu, Serban P, Naggar, Isaac, Wang, Bo, Kim, Young-Bum, Blaustein, Robert O, Karas, Richard H, Liao, Ronglih, Mathews, Clayton E, Galper, Jonas B

“…RATIONALE:Diabetic autonomic neuropathy (DAN), a major complication of diabetes mellitus, is characterized, in part, by impaired cardiac parasympathetic…”
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Phenylephrine as a simulated intravascular epidural test dose in pediatrics: a pilot study by Pancaro, Carlo, Nasr, Viviane G., Paulus, Jessica K., Bonney, Iwona, Flores, Alejandro F., Galper, Jonas B., Ahmed, Iqbal

“…Summary Background A test dose is used to detect intravascular injection during neuraxial block in pediatrics. Accidental intravascular epidural local…”
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Signaling Via Calcineurin and the Canonical Transient Receptor Protein-6 Channel (TRPC6) Requires Endoglin in Right Ventricle Pressure Overload by Kapur, Navin K, Qiao, Xiaoying, Paruchuri, Vikram, Mackey, Emily E, Daly, Gerard, Ughreja, Keshan, Levine, Jonathan, Aronovitz, Mark J, Jin, Hongwei, Galper, Jonas B, Karas, Richard H

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Simvastatin potentiates tumor necrosis factor α-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA by Tang, Dongjiang, Park, Ho-Jin, Georgescu, Serban P., Sebti, Saïd M., Hamilton, Andrew D., Galper, Jonas B.

“…HMG-CoA reductase inhibitors (statins) are widely used in the treatment and prevention of atherosclerosis. Here we demonstrate that the HMG-CoA reductase…”
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Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Gαi2, a possible molecular marker for parasympathetic responsiveness by WELZIG, C. Michael, SHIN, Dong-Gu, PARK, Ho-Jin, KIM, Young-Jo, SAUL, J. Philip, GALPER, Jonas B

“…Background— We have previously demonstrated in an in vitro model for lipid lowering that lipoprotein depletion resulted in a marked increase in the negative…”
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3-Hydroxy-3-Methylglutaryl CoA Reductase Inhibitors up-Regulate Transforming Growth factor-β Signaling in Cultured Heart Cells via Inhibition of Geranylgeranylation of RhoA GTPase by Park, H J, Galper, J B

“…Transforming growth factor-β (TGFβ) signaling has been shown to play a role in cardiac development as well as in the pathogenesis of cardiovascular disease…”
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