Search Results - "Galmarini, Carlos M."

A review of trabectedin (ET-743): a unique mechanism of action by D'Incalci, Maurizio, Galmarini, Carlos M

“…Trabectedin (ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata, with a chemical structure characterized by three fused…”
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Role of Macrophage Targeting in the Antitumor Activity of Trabectedin by Germano, Giovanni, Frapolli, Roberta, Belgiovine, Cristina, Anselmo, Achille, Pesce, Samantha, Liguori, Manuela, Erba, Eugenio, Uboldi, Sarah, Zucchetti, Massimo, Pasqualini, Fabio, Nebuloni, Manuela, van Rooijen, Nico, Mortarini, Roberta, Beltrame, Luca, Marchini, Sergio, Fuso Nerini, Ilaria, Sanfilippo, Roberta, Casali, Paolo G., Pilotti, Silvana, Galmarini, Carlos M., Anichini, Andrea, Mantovani, Alberto, D’Incalci, Maurizio, Allavena, Paola

“…There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently approved chemotherapeutic…”
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Cancer chemotherapy: A critical analysis of its 60 years of history by Galmarini, Darío, Galmarini, Carlos M, Galmarini, Felipe C

“…Abstract Chemotherapy has already proven widely effective in the treatment of cancer, occupying a prominent place in the current therapeutic arsenal. However,…”
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Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin by Losada, Alejandro, Muñoz-Alonso, María José, García, Carolina, Sánchez-Murcia, Pedro A., Martínez-Leal, Juan Fernando, Domínguez, Juan Manuel, Lillo, M. Pilar, Gago, Federico, Galmarini, Carlos M.

“…eEF1A2 is one of the isoforms of the alpha subunit of the eukaryotic Elongation Factor 1. It is overexpressed in human tumors and is endowed with oncogenic…”
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Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells by Galmarini, Carlos M, Martin, Maud, Bouchet, Benjamin Pierre, Guillen-Navarro, María José, Martínez-Diez, Marta, Martinez-Leal, Juan Fernando, Akhmanova, Anna, Aviles, Pablo

“…Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived…”
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Trabectedin and plitidepsin: drugs from the sea that strike the tumor microenvironment by Galmarini, Carlos M, D'Incalci, Maurizio, Allavena, Paola

“…The prevailing paradigm states that cancer cells acquire multiple genetic mutations in oncogenes or tumor suppressor genes whose respective…”
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Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations by Bueren-Calabuig, Juan A., Giraudon, Christophe, Galmarini, Carlos M., Egly, Jean Marc, Gago, Federico

“…The difference in melting temperature of a double-stranded (ds) DNA molecule in the absence and presence of bound ligands can provide experimental information…”
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Deep Neural Frameworks Improve the Accuracy of General Practitioners in the Classification of Pigmented Skin Lesions by Lucius, Maximiliano, De All, Jorge, De All, José Antonio, Belvisi, Martín, Radizza, Luciana, Lanfranconi, Marisa, Lorenzatti, Victoria, Galmarini, Carlos M

“…This study evaluated whether deep learning frameworks trained in large datasets can help non-dermatologist physicians improve their accuracy in categorizing…”
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Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death by Molina-Guijarro, José Manuel, García, Carolina, Macías, Álvaro, García-Fernández, Luis Francisco, Moreno, Cristina, Reyes, Fernando, Martínez-Leal, Juan Fernando, Fernández, Rogelio, Martínez, Valentín, Valenzuela, Carmen, Lillo, M Pilar, Galmarini, Carlos M

“…Plasma membrane integrity is essential for cell life. Any major break on it immediately induces the death of the affected cell. Different molecules were…”
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Unique features of trabectedin mechanism of action by Larsen, Annette K., Galmarini, Carlos M., D’Incalci, Maurizio

“…Trabectedin (Yondelis ® , ET-743) is a marine-derived natural product that was initially isolated from the marine ascidian Ecteinascidia turbinata and is…”
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Class III β-Tubulin Isotype Predicts Response in Advanced Breast Cancer Patients Randomly Treated Either with Single-Agent Doxorubicin or Docetaxel by Carlos M. Galmarini, Isabelle Treilleux, Fatima Cardoso, Chantal Bernard-Marty, Virginie Durbecq, David Gancberg, Marie-Christine Bissery, Marianne Paesmans, Denis Larsimont, Martine J. Piccart, Angelo Di Leo, Charles Dumontet

“…Purpose: To evaluate the role of microtubule-associated variables as potential predictors of response and clinical outcome in patients with advanced breast…”
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Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines by Ávila-Arroyo, Sonia, Nuñez, Gema Santamaría, García-Fernández, Luis Francisco, Galmarini, Carlos M

“…Trabectedin induces synthetic lethality in tumor cells carrying defects in homologous recombinant DNA repair. We evaluated the effect of concomitant inhibition…”
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Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models by Belgiovine, Cristina, Bello, Ezia, Liguori, Manuela, Craparotta, Ilaria, Mannarino, Laura, Paracchini, Lara, Beltrame, Luca, Marchini, Sergio, Galmarini, Carlos M, Mantovani, Alberto, Frapolli, Roberta, Allavena, Paola, D'Incalci, Maurizio

“…Background: Lurbinectedin is a novel anticancer agent currently undergoing late-stage (Phase II /III) clinical evaluation in platinum-resistant ovarian,…”
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ErbB protein modifications are secondary to severe cell membrane alterations induced by elisidepsin treatment by Váradi, Tímea, Roszik, Janos, Lisboa, Duarte, Vereb, György, Molina-Guijarro, José Manuel, Galmarini, Carlos M., Szöllősi, János, Nagy, Peter

“…Elisidepsin is a marine-derived anti-tumor agent with unique mechanism of action. It has been suggested to induce necrosis associated with severe membrane…”
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Irvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells by Molina-Guijarro, José M, Macías, Álvaro, García, Carolina, Muñoz, Eva, García-Fernández, Luis F, David, Miren, Núñez, Lucía, Martínez-Leal, Juan F, Moneo, Victoria, Cuevas, Carmen, Lillo, M Pilar, Villalobos Jorge, Carlos, Valenzuela, Carmen, Galmarini, Carlos M

“…Irvalec is a marine-derived antitumor agent currently undergoing phase II clinical trials. In vitro, Irvalec induces a rapid loss of membrane integrity in…”
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Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines by Galmarini, Carlos M, Warren, Galya, Kohli, Ekta, Zeman, Arin, Mitin, Anton, Vinogradov, Serguei V

“…The therapeutic efficiency of anticancer nucleoside analogues (NA) strongly depends on their intracellular accumulation and conversion into 5′-triphosphates…”
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Hypoxia reduces the efficiency of elisidepsin by inhibiting hydroxylation and altering the structure of lipid rafts by Király, Anna, Váradi, Tímea, Hajdu, Tímea, Rühl, Ralph, Galmarini, Carlos M, Szöllősi, János, Nagy, Peter

“…The mechanism of action of elisidepsin (PM02734, Irvalec®) is assumed to involve membrane permeabilization via attacking lipid rafts and hydroxylated lipids…”
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Drug Resistance and the Solid Tumor Microenvironment by Trédan, Olivier, Galmarini, Carlos M., Patel, Krupa, Tannock, Ian F.

“…Resistance of human tumors to anticancer drugs is most often ascribed to gene mutations, gene amplification, or epigenetic changes that influence the uptake,…”
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Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells by Jordheim, Lars Petter, Guittet, Olivier, Lepoivre, Michel, Galmarini, Carlos M, Dumontet, Charles

“…Resistance to cytotoxic nucleoside analogues is a major problem in cancer treatment. The cellular mechanisms involved in this phenomenon have been studied for…”
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c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity by Muñoz-Alonso, María J, Álvarez, Enrique, Guillén-Navarro, María José, Pollán, Marina, Avilés, Pablo, Galmarini, Carlos M, Muñoz, Alberto

“…Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle…”
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