Search Results - "Galluzzi, Lorenzo"

Intratumoral heterogeneity in cancer progression and response to immunotherapy by Vitale, Ilio, Shema, Efrat, Loi, Sherene, Galluzzi, Lorenzo

“…Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed by trophic, metabolic, immunological, and therapeutic factors. The…”
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Immunogenic cell stress and death by Kroemer, Guido, Galassi, Claudia, Zitvogel, Laurence, Galluzzi, Lorenzo

“…Dying mammalian cells emit numerous signals that interact with the host to dictate the immunological correlates of cellular stress and death. In the absence of…”
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Decoding cell death signals in liver inflammation by Brenner, Catherine, Galluzzi, Lorenzo, Kepp, Oliver, Kroemer, Guido

“…Summary Inflammation can be either beneficial or detrimental to the liver, depending on multiple factors. Mild (i.e., limited in intensity and destined to…”
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Macrophages and Metabolism in the Tumor Microenvironment by Vitale, Ilio, Manic, Gwenola, Coussens, Lisa M., Kroemer, Guido, Galluzzi, Lorenzo

“…Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell population of the tumor microenvironment (TME) that can account for up to 50%…”
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Autophagy and Mitophagy in Cardiovascular Disease by Bravo-San Pedro, José Manuel, Kroemer, Guido, Galluzzi, Lorenzo

“…Autophagy contributes to the maintenance of intracellular homeostasis in most cells of cardiovascular origin, including cardiomyocytes, endothelial cells, and…”
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Detection of immunogenic cell death and its relevance for cancer therapy by Fucikova, Jitka, Kepp, Oliver, Kasikova, Lenka, Petroni, Giulia, Yamazaki, Takahiro, Liu, Peng, Zhao, Liwei, Spisek, Radek, Kroemer, Guido, Galluzzi, Lorenzo

“…Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely…”
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The secret ally: immunostimulation by anticancer drugs by Galluzzi, Lorenzo, Senovilla, Laura, Zitvogel, Laurence, Kroemer, Guido

“…Key Points Throughout the past century, conventional anticancer chemotherapeutics have been used based on their ability to selectively kill neoplastic cells…”
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Metabolic control of cell death by Green, Douglas R., Galluzzi, Lorenzo, Kroemer, Guido

“…Beyond their contribution to basic metabolism, the major cellular organelles, in particular mitochondria, can determine whether cells respond to stress in an…”
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Targeting replication stress to tackle cancer stem cells by Galluzzi, Lorenzo

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Immunological impact of cell death signaling driven by radiation on the tumor microenvironment by Rodriguez-Ruiz, Maria Esperanza, Vitale, Ilio, Harrington, Kevin J., Melero, Ignacio, Galluzzi, Lorenzo

“…Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial…”
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Mitotic catastrophe: a mechanism for avoiding genomic instability by Kroemer, Guido, Vitale, Ilio, Galluzzi, Lorenzo, Castedo, Maria

“…The improper distribution of chromosomes during mitosis can contribute to malignant transformation. Higher eukaryotes have developed strategies for eliminating…”
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Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors by Galluzzi, Lorenzo, Humeau, Juliette, Buqué, Aitziber, Zitvogel, Laurence, Kroemer, Guido

“…Conventional chemotherapeutics have been developed into clinically useful agents based on their ability to preferentially kill malignant cells, generally owing…”
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Calreticulin and cancer by Fucikova, Jitka, Spisek, Radek, Kroemer, Guido, Galluzzi, Lorenzo

“…Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a spectrum of cellular processes. In healthy cells, CALR operates as a…”
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Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles by Vanpouille-Box, Claire, Hoffmann, Jules A., Galluzzi, Lorenzo

“…Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING signalling, play a critical role in the preservation of cellular and…”
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Immunomodulation by anticancer cell cycle inhibitors by Petroni, Giulia, Formenti, Silvia C., Chen-Kiang, Selina, Galluzzi, Lorenzo

“…Cell cycle proteins that are often dysregulated in malignant cells, such as cyclin-dependent kinase 4 (CDK4) and CDK6, have attracted considerable interest as…”
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Molecular mechanisms of necroptosis: an ordered cellular explosion by Vandenabeele, Peter, Kroemer, Guido, Galluzzi, Lorenzo, Vanden Berghe, Tom

“…Key Points Although for a long time necrosis was considered to be a purely accidental cell death subroutine, multiple lines of evidence now show that necrotic…”
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Mitochondria and the Autophagy—Inflammation—Cell Death Axis in Organismal Aging by Green, Douglas R., Galluzzi, Lorenzo, Kroemer, Guido

“…Alterations of mitochondrial functions are linked to multiple degenerative or acute diseases. As mitochondria age in our cells, they become progressively…”
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Immunogenic Cell Death in Cancer Therapy by Kroemer, Guido, Galluzzi, Lorenzo, Kepp, Oliver, Zitvogel, Laurence

“…Depending on the initiating stimulus, cancer cell death can be immunogenic or nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition…”
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Cytosolic DNA Sensing in Organismal Tumor Control by Vanpouille-Box, Claire, Demaria, Sandra, Formenti, Silvia C., Galluzzi, Lorenzo

“…Besides constituting a first layer of defense against microbial challenges, the detection of cytosolic DNA is fundamental for mammalian organisms to control…”
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Optimising efficacy and reducing toxicity of anticancer radioimmunotherapy by Deutsch, Eric, Prof, Chargari, Cyrus, Prof, Galluzzi, Lorenzo, PhD, Kroemer, Guido, Prof

“…SummaryImmunotherapy is radically changing the clinical management of patients affected by an increasingly wide array of tumours. However, not all patients…”
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