Search Results - "Gallot, Yann S"

Molecular mechanisms of cancer cachexia‐related loss of skeletal muscle mass: data analysis from preclinical and clinical studies by Martin, Agnès, Gallot, Yann S., Freyssenet, Damien

“…Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the quality of life of cancer patients, decreases the efficiency of…”
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Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia by Bohnert, Kyle R., Gallot, Yann S., Sato, Shuichi, Xiong, Guangyan, Hindi, Sajedah M., Kumar, Ashok

“…ABSTRACT Cachexia is a devastating syndrome that causes morbidity and mortality in a large number of patients with cancer. However, the mechanisms of cancer…”
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Confounding Roles of ER Stress and the Unfolded Protein Response in Skeletal Muscle Atrophy by Gallot, Yann S, Bohnert, Kyle R

“…Skeletal muscle is an essential organ, responsible for many physiological functions such as breathing, locomotion, postural maintenance, thermoregulation, and…”
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The Toll-Like Receptor/MyD88/XBP1 Signaling Axis Mediates Skeletal Muscle Wasting during Cancer Cachexia by Bohnert, Kyle R., Goli, Praneeth, Roy, Anirban, Sharma, Aditya K., Xiong, Guangyan, Gallot, Yann S., Kumar, Ashok

“…Skeletal muscle wasting causes both morbidity and mortality of cancer patients. Accumulating evidence suggests that the markers of endoplasmic reticulum (ER)…”
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MyD88 promotes myoblast fusion in a cell-autonomous manner by Hindi, Sajedah M., Shin, Jonghyun, Gallot, Yann S., Straughn, Alex R., Simionescu-Bankston, Adriana, Hindi, Lubna, Xiong, Guangyan, Friedland, Robert P., Kumar, Ashok

“…Myoblast fusion is an indispensable step for skeletal muscle development, postnatal growth, and regeneration. Myeloid differentiation primary response gene 88…”
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Myostatin gene inactivation prevents skeletal muscle wasting in cancer by Gallot, Yann S, Durieux, Anne-Cécile, Castells, Josiane, Desgeorges, Marine M, Vernus, Barbara, Plantureux, Léa, Rémond, Didier, Jahnke, Vanessa E, Lefai, Etienne, Dardevet, Dominique, Nemoz, Georges, Schaeffer, Laurent, Bonnieu, Anne, Freyssenet, Damien G

“…Cachexia is a muscle-wasting syndrome that contributes significantly to morbidity and mortality of many patients with advanced cancers. However, little is…”
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The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration by Xiong, Guangyan, Hindi, Sajedah M, Mann, Aman K, Gallot, Yann S, Bohnert, Kyle R, Cavener, Douglas R, Whittemore, Scott R, Kumar, Ashok

“…Regeneration of skeletal muscle in adults is mediated by satellite stem cells. Accumulation of misfolded proteins triggers endoplasmic reticulum stress that…”
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Effect of Denervation on XBP1 in Skeletal Muscle and the Neuromuscular Junction by Walter, Lisa A, Blake, Lauren P, Gallot, Yann S, Arends, Charles J, Sozio, Randall S, Onifer, Stephen M, Bohnert, Kyle R

“…Denervation of skeletal muscle is a debilitating consequence of injury of the peripheral nervous system, causing skeletal muscle to experience robust atrophy…”
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Hypothalamic–pituitary–adrenal axis activation and glucocorticoid‐responsive gene expression in skeletal muscle and liver of Apc mice by Martin, Agnès, Castells, Josiane, Allibert, Valentine, Emerit, Andréa, Zolotoff, Cindy, Cardot‐Ruffino, Victoire, Gallot, Yann S., Vernus, Barbara, Chauvet, Véronique, Bartholin, Laurent, Schaeffer, Laurent, Durieux, Anne‐Cécile, Hourdé, Christophe, Favier, François B., Mazelin, Laetitia, Freyssenet, Damien

“…Background Cancer patients at advanced stages experience a severe depletion of skeletal muscle compartment together with a decrease in muscle function, known…”
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Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress by Britto, Florian A, Cortade, Fabienne, Belloum, Yassine, Blaquière, Marine, Gallot, Yann S, Docquier, Aurélie, Pagano, Allan F, Jublanc, Elodie, Bendridi, Nadia, Koechlin-Ramonatxo, Christelle, Chabi, Béatrice, Francaux, Marc, Casas, François, Freyssenet, Damien, Rieusset, Jennifer, Giorgetti-Peraldi, Sophie, Carnac, Gilles, Ollendorff, Vincent, Favier, François B

“…Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized…”
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Distinct roles of TRAF6 and TAK1 in the regulation of adipocyte survival, thermogenesis program, and high-fat diet-induced obesity by Gallot, Yann S, McMillan, Joseph D, Xiong, Guangyan, Bohnert, Kyle R, Straughn, Alex R, Hill, Bradford G, Kumar, Ashok

“…Chronic low-grade inflammation, adipocyte hypertrophy, and glucose intolerance are common features of obesity and a risk factor for cancer. Tumor necrosis…”
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Editorial: Emerging Mechanisms for Skeletal Muscle Mass Regulation by Ogura, Yuji, Sato, Shuichi, Gallot, Yann S., Arthur, Susan Tsivitse

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PERK regulates skeletal muscle mass and contractile function in adult mice by Gallot, Yann S., Bohnert, Kyle R., Straughn, Alex R., Xiong, Guangyan, Hindi, Sajedah M., Kumar, Ashok

“…ABSTRACT Skeletal muscle mass is regulated by the coordinated activation of several anabolic and catabolic pathways. The endoplasmic reticulum (ER) is a major…”
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TAK1 regulates skeletal muscle mass and mitochondrial function by Hindi, Sajedah M., Sato, Shuichi, Xiong, Guangyan, Bohnert, Kyle R., Gibb, Andrew A., Gallot, Yann S., McMillan, Joseph D., Hill, Bradford G., Uchida, Shizuka, Kumar, Ashok

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MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice by Gallot, Yann S, Straughn, Alex R, Bohnert, Kyle R, Xiong, Guangyan, Hindi, Sajedah M, Kumar, Ashok

“…Abstract Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, leads to severe muscle wasting and eventual death of the afflicted…”
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TAK1 regulates skeletal muscle mass and mitochondrial function by Hindi, Sajedah M, Sato, Shuichi, Xiong, Guangyan, Bohnert, Kyle R, Gibb, Andrew A, Gallot, Yann S, McMillan, Joseph D, Hill, Bradford G, Uchida, Shizuka, Kumar, Ashok

“…Skeletal muscle mass is regulated by a complex array of signaling pathways. TGF-β-activated kinase 1 (TAK1) is an important signaling protein, which regulates…”
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