Search Results - "Gallo, Paola Maria"

Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation by Bruno, Paolo, Micoli, Alessandra, Corsi, Mauro, Pala, Daniele, Guariento, Sara, Fiorelli, Claudio, Ronchi, Paolo, Fioni, Alessandro, Gallo, Paola Maria, Marenghi, Giulia, Bertolini, Serena, Capacchi, Silvia, Mileo, Valentina, Biagetti, Matteo, Capelli, Anna Maria

“…A hit-to-lead campaign pursuing the identification of novel inhalant small-molecule phosphatidylinositol 3-kinase (PI3K) inhibitors for the treatment of…”
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Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2‑((6-Amino‑9H‑purin-9-yl)methyl)-5-methyl-3‑(o‑tolyl)quinazolin-4(3H)‑one (IC87114) and Its Conformationally Restricted Analogs by Lodola, Alessio, Bertolini, Serena, Biagetti, Matteo, Capacchi, Silvia, Facchinetti, Fabrizio, Gallo, Paola Maria, Pappani, Alice, Mor, Marco, Pala, Daniele, Rivara, Silvia, Visentini, Filippo, Corsi, Mauro, Capelli, Anna Maria

“…IC87114 [compound 1, (2-((6-amino-9H-purin-9-yl)­methyl)-5-methyl-3-(o-tolyl)­quinazolin-4­(3H)-one)] is a potent PI3K inhibitor selective for the δ isoform…”
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Functionalized pyrazoles and pyrazolo[3,4- d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity by Biagini, Pierfrancesco, Biancalani, Claudio, Graziano, Alessia, Cesari, Nicoletta, Giovannoni, Maria Paola, Cilibrizzi, Agostino, Piaz, Vittorio Dal, Vergelli, Claudia, Crocetti, Letizia, Delcanale, Maurizio, Armani, Elisabetta, Rizzi, Andrea, Puccini, Paola, Gallo, Paola Maria, Spinabelli, Daniele, Caruso, Paola

“…A series of pyrazoles and pyrazolo[3,4- d]pyridazinones were synthesized and evaluated for their PDE4 inhibitory activity. All the pyrazoles were found devoid…”
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