Search Results - "Gallo, K. A."

Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells by Misek, S. A., Appleton, K. M., Dexheimer, T. S., Lisabeth, E. M., Lo, R. S., Larsen, S. D., Gallo, K. A., Neubig, R. R.

“…Over half of cutaneous melanoma tumors have BRAF V600E/K mutations. Acquired resistance to BRAF inhibitors (BRAFi) remains a major hurdle in attaining durable…”
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MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells by Chen, J, Miller, E M, Gallo, K A

“…The malignant phenotype in breast cancer is driven by aberrant signal transduction pathways. Mixed-lineage kinase-3 (MLK3) is a mammalian mitogen-activated…”
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MLK3 regulates FRA-1 and MMPs to drive invasion and transendothelial migration in triple-negative breast cancer cells by Rattanasinchai, C, Llewellyn, B J, Conrad, S E, Gallo, K A

“…Mixed-lineage kinase 3 (MLK3), a mitogen-activated protein kinase kinase kinase (MAP3K), has critical roles in metastasis of triple-negative breast cancer…”
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RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP by Gaudino, G., Follenzi, A., Naldini, L., Collesi, C., Santoro, M., Gallo, K.A., Godowski, P.J., Comoglio, P.M.

“…RON, a cDNA homologous to the hepatocyte growth factor (HGF) receptor gene (MET), encodes a putative tyrosine kinase. Here we show that the RON gene is…”
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Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity by Gallo, K A, Mark, M R, Scadden, D T, Wang, Z, Gu, Q, Godowski, P J

“…Protein kinase play important roles in the growth and differentiation of cells. We have isolated cDNA clones from the human megakaryocytic cell line CMK11-5…”
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Purification, cloning, and cofactor independence of glutamate racemase from Lactobacillus by Gallo, Kathleen A, Knowles, Jeremy R

“…Glutamate racemase has been purified more than 12,000-fold from Lactobacillus fermenti. The racemase gene has been cloned using standard hybridization…”
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Mechanism of the reaction catalyzed by glutamate racemase by Gallo, Kathleen A, Tanner, Martin E, Knowles, Jeremy R

“…The mechanism of the cofactor-independent glutamate racemase from Lactobacillus has been studied. The possible formation of an acylenzyme intermediate during…”
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Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase by Tanner, Martin E, Gallo, Kathleen A, Knowles, Jeremy R

“…Primary kinetic isotope effects on Vmax were observed in both reaction directions upon racemizing samples of [2-2H]glutamate with the cofactor-independent…”
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Autoinhibition of Mixed Lineage Kinase 3 through Its Src Homology 3 Domain by Zhang, Hua, Gallo, Kathleen A.

“…Mixed lineage kinase 3 (MLK3) is a serine/threonine protein kinase that functions as a mitogen-activated protein kinase kinase kinase to activate the c-Jun…”
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Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation by Böck, B C, Vacratsis, P O, Qamirani, E, Gallo, K A

“…Src homology 3 domain (SH3)-containing proline-rich protein kinase (SPRK)/mixed-lineage kinase (MLK)-3 is a serine/threonine kinase that upon overexpression in…”
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Synthesis of reactive metabolite-analogues of cyclophosphamide for comparisons of NMR kinetic parameters and anticancer screening data by Ludeman, S M, Boyd, V L, Regan, J B, Gallo, K A, Zon, G, Ishii, K

“…Ozonolysis of compounds with the general structure CH2 = CHR1CHR2CH2OP(O) (NHR3)NR42 gave, in each case, one major product which was an analogue of the…”
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LRRK2 in Parkinson's disease: protein domains and functional insights by Mata, Ignacio F., Wedemeyer, William J., Farrer, Matthew J., Taylor, Julie P., Gallo, Kathleen A.

“…Parkinson's disease (PD) is the most common motor neurodegenerative disease. Mutations in the gene encoding leucine-rich repeat kinase 2 ( LRRK2) have been…”
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Mixed-lineage kinase control of JNK and p38 MAPK pathways by Gallo, Kathleen A, Johnson, Gary L

“…Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38…”
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Alkyl phosphotriester modified oligodeoxyribonucleotides. V. Synthesis and absolute configuration of Rp and Sp diastereomers of an ethyl phosphotriester (Et) modified EcoRI recognition sequence, d[GGAA(Et)TTCC]. A synthetic approach to regio- and stereospecific ethylation-interference studies by Gallo, Kathleen A., Shao, Kai-liu, Phillips, Lawrence R., Regan, Judith B., Koziolkiewicz, Maria, Uznanski, Bogdan, Stec, Wojciech J., Zon, Gerald

“…Protected deoxynucleoside 3′-O-ethyl-N, N-diisopropylphosphoramidite reagents were prepared for use in the automated synthesis of ethyl phosphotriester (Et)…”
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Nuclear magnetic resonance and circular dichroism studies of a duplex - single-stranded hairpin loop equilibrium for the oligodeoxyribonucleotide sequence d(CGCGATTCGCG) by Summers, Michael F., Byrd, R.Andrew, Gallo, Kathleen A., Samson, Carrie J., Zon, Gerald, Egan, William

“…Nuclear magnetic resonance (NMR) and circular dichroism (CD) studies have been carried out with the oligodeoxyribonucleotide mismatch sequence, d(CGCGATTCGCG),…”
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Synthesis and antitumor activity of cyclophosphamide analogs. 4. Preparation, kinetic studies, and anticancer screening of phenylketophosphamide and similar compounds related to the cyclophosphamide metabolite aldophosphamide by Ludeman, Susan Marie, Boyd, Victoria Lee, Regan, Judith B, Gallo, Kathleen A, Zon, Gerald, Ishii, Kiyoshi

“…Phenyl ketone phosphorodiamidates [C6H5C(O)CH2CH2OP(O)NHR1NR2R3] were synthesized in conjunction with an ongoing investigation into the effects of substituents…”
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Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but Is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylation of Thr258 of murine MITOGEN-ACTIVATED protein kinase kinase 4 by Vacratsis, P O, Gallo, K A

“…Src homology 3 domain-containing proline-rich kinase (SPRK)/mixed lineage kinase-3 is a serine/threonine kinase that has been identified as an upstream…”
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Analytical studies of ‘mixed sequence’ oligodeoxyribonucleotides synthesized by competitive coupling of either methyl- or β-cyanoethyl-N,N-diisopropylamino phosphoramidite reagents, including 2′-deoxyinosine by Zon, Gerald, Gallo, Kathleen A, Samson, Carrie J., Shao, Kai-liu, Summers, Michael F., Byrd, R.Andrew

“…High-performance liquid chromatography (HPLC) and 1H/31P nuclear magnetic resonance (NMR) spectroscopy were used to measure the molar ratio of…”
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Cdc42 Induces Activation Loop Phosphorylation and Membrane Targeting of Mixed Lineage Kinase 3 by Du, Yan, Böck, Barbara C., Schachter, Karen A., Chao, Mary, Gallo, Kathleen A.

“…Mixed lineage kinase 3 (MLK3) functions as a mitogen-activated protein kinase kinase kinase to activate multiple mitogen-activated protein kinase pathways. Our…”
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Economic burden and clinical impact of preoperative opioid dependence for patients undergoing lower extremity bypass surgery by Aizpuru, Matthew, BA, Gallo, Lindsay K., BA, Farley, Kevin X., BS, Wagner, Eric R., MD, Benarroch-Gampel, Jaime, MD, Jordan, William D., MD, Crawford, Robert S., MD

“…AbstractObjectiveSurgeons' prescription practices and the opioid epidemic have received significant attention in the media. Limited data exist, however, on the…”
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