Adhesion molecule profiles of B-cell non-Hodgkin's lymphomas in the leukemic phase

We evaluated the expression of 10 adhesion molecules on peripheral blood tumor cells of 17 patients with chronic lymphocytic leukemia, 17 with mantle-cell lymphoma, and 13 with nodal or splenic marginal B-cell lymphoma, all in the leukemic phase and before the beginning of any therapy. The diagnosis...

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Published in:	Brazilian journal of medical and biological research Vol. 39; no. 10; pp. 1349 - 1355
Main Authors:	Matos, D M, Rizzatti, E G, Garcia, A B, Gallo, D A P, Falcão, R P
Format:	Journal Article
Language:	English
Published:	Brazil Associação Brasileira de Divulgação Científica 01-10-2006
Subjects:	Adhesion molecules Adult Aged Aged, 80 and over BIOLOGY Biomarkers, Tumor - blood Biomarkers, Tumor - metabolism CD49c/CD49d Cell Adhesion Molecules - biosynthesis Diagnosis, Differential Female Flow Cytometry Humans Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukocytes, Mononuclear - metabolism Lymphoma, B-Cell - metabolism Lymphoma, B-Cell, Marginal Zone - metabolism Lymphoma, Mantle-Cell - metabolism Male MEDICINE, RESEARCH & EXPERIMENTAL Middle Aged Non-Hodgkin's lymphoma Flow cytometry Adhesion molecules Non-Hodgkin's lymphoma CD49c/CD49d
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Summary:	We evaluated the expression of 10 adhesion molecules on peripheral blood tumor cells of 17 patients with chronic lymphocytic leukemia, 17 with mantle-cell lymphoma, and 13 with nodal or splenic marginal B-cell lymphoma, all in the leukemic phase and before the beginning of any therapy. The diagnosis of B-cell non-Hodgkin's lymphomas was based on cytological, histological, immunophenotypic, and molecular biology methods. The mean fluorescence intensity of the adhesion molecules in tumor cells was measured by flow cytometry of CD19-positive cells and differed amongst the types of lymphomas. Comparison of chronic lymphocytic leukemia and mantle-cell lymphoma showed that the former presented a higher expression of CD11c and CD49c, and a lower expression of CD11b and CD49d adhesion molecules. Comparison of chronic lymphocytic leukemia and marginal B-cell lymphoma showed that the former presented a higher expression of CD49c and a lower expression of CD11a, CD11b, CD18, CD49d, CD29, and CD54. Finally, comparison of mantle-cell lymphoma and marginal B-cell lymphoma showed that marginal B-cell lymphoma had a higher expression of CD11a, CD11c, CD18, CD29, and CD54. Thus, the CD49c/CD49d pair consistently demonstrated a distinct pattern of expression in chronic lymphocytic leukemia compared with mantle-cell lymphoma and marginal B-cell lymphoma, which could be helpful for the differential diagnosis. Moreover, the distinct profiles of adhesion molecules in these diseases may be responsible for their different capacities to invade the blood stream.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0100-879X 1414-431X 0100-879X 1414-431X
DOI:	10.1590/S0100-879X2006001000011