Search Results - "Gallina, Iryna S."

Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain by Deng, Wei, Saxe, Michael D, Gallina, Iryna S, Gage, Fred H

“…Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains unknown when adult-born DGCs become involved in the cognitive…”
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Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability by Wang, Meiyan, Wei, Pei-Chi, Lim, Christina K., Gallina, Iryna S., Marshall, Sara, Marchetto, Maria C., Alt, Frederick W., Gage, Fred H.

“…The association between macrocephaly and autism spectrum disorder (ASD) suggests that the mechanisms underlying excessive neural growth could contribute to ASD…”
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A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons by Jaeger, Baptiste N., Linker, Sara B., Parylak, Sarah L., Barron, Jerika J., Gallina, Iryna S., Saavedra, Christian D., Fitzpatrick, Conor, Lim, Christina K., Schafer, Simon T., Lacar, Benjamin, Jessberger, Sebastian, Gage, Fred H.

“…Activity-induced remodeling of neuronal circuits is critical for memory formation. This process relies in part on transcription, but neither the rate of…”
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Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation by Toda, Tomohisa, Bedrosian, Tracy A., Schafer, Simon T., Cuoco, Michael S., Linker, Sara B., Ghassemzadeh, Saeed, Mitchell, Lisa, Whiteley, Jack T., Novaresi, Nicole, McDonald, Aidan H., Gallina, Iryna S., Yoon, Hyojung, Hester, Mark E., Pena, Monique, Lim, Christina, Suljic, Emelia, AlFatah Mansour, Abed, Boulard, Matthieu, Parylak, Sarah L., Gage, Fred H.

“…Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome…”
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Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain by Wang, Meiyan, Zhang, Lei, Novak, Sammy Weiser, Yu, Jingting, Gallina, Iryna S, Xu, Lynne L, Lim, Christina K, Fernandes, Sarah, Shokhirev, Maxim N, Williams, April E, Saxena, Monisha D, Coorapati, Shashank, Parylak, Sarah L, Quintero, Cristian, Molina, Elsa, Andrade, Leonardo R, Manor, Uri, Gage, Fred H

“…Astrocytes, the most abundant glial cell type in the brain, are underrepresented in traditional cortical organoid models due to the delayed onset of cortical…”
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Neuronal activity‐related transcription is blunted in immature compared to mature dentate granule cells by Parylak, Sarah L., Qiu, Fan, Linker, Sara B., Gallina, Iryna S., Lim, Christina K., Preciado, David, McDonald, Aidan H., Zhou, Xavier, Gage, Fred H.

“…Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus (DG) function. Although…”
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