Search Results - "Gallimore, Phillip H"

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression by Turnell, Andrew S, Stewart, Grant S, Grand, Roger J. A, Rookes, Susan M, Martin, Ashley, Yamano, Hiroyuki, Elledge, Stephen J, Gallimore, Phillip H

“…The anaphase-promoting complex/cyclosome (APC/C) is a multicomponent E3 ubiquitin ligase that, by targeting protein substrates for 26S proteasome-mediated…”
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Roles for APIS and the 20S proteasome in adenovirus E1A-dependent transcription by Rasti, Mozhgan, Grand, Roger JA, Yousef, Ahmed F, Shuen, Michael, Mymryk, Joe S, Gallimore, Phillip H, Turnell, Andrew S

“…We have determined distinct roles for different proteasome complexes in adenovirus (Ad) E1A‐dependent transcription. We show that the 19S ATPase, S8, as a…”
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Identification of an Arginine-Rich Motif in Human Papillomavirus Type 1 E1^E4 Protein Necessary for E4-Mediated Inhibition of Cellular DNA Synthesis In Vitro and in Cells by ROBERTS, Sally, KINGSBURY, Sarah R, STOEBER, Kai, KNIGHT, Gillian L, GALLIMORE, Phillip H, WILLIAMS, Gareth H

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Recruitment of CBP/p300, TATA-Binding Protein, and S8 to Distinct Regions at the N Terminus of Adenovirus E1A by RASTI, Mozhgan, GRAND, Roger J. A, MYMRYK, Joe S, GALLIMORE, Phillip H, TURNELL, Andrew S

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Cooperation between Different Forms of the Human Papillomavirus Type 1 E4 Protein To Block Cell Cycle Progression and Cellular DNA Synthesis by KNIGHT, Gillian L, GRAINGER, John R, GALLIMORE, Phillip H, ROBERTS, Sally

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The ND10 Component Promyelocytic Leukemia Protein Relocates to Human Papillomavirus Type 1 E4 Intranuclear Inclusion Bodies in Cultured Keratinocytes and in Warts by Roberts, Sally, Hillman, Michele L, Knight, Gillian L, Gallimore, Phillip H

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The Targeting of the Proteasomal Regulatory Subunit S2 by Adenovirus E1A Causes Inhibition of Proteasomal Activity and Increased p53 Expression by Zhang, Xian, Turnell, Andrew S., Gorbea, Carlos, Mymryk, Joe S., Gallimore, Phillip H., Grand, Roger J.A.

“…Although adenovirus early region 1A (AdE1A) can modulate protein expression through its interaction with transcriptional regulators it can also influence the…”
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Acetylation at a lysine residue adjacent to the CtBP binding motif within adenovirus 12 E1A causes structural disruption and limited reduction of CtBP binding by Molloy, David, Mapp, Katie L., Webster, Rachel, Gallimore, Phillip H., Grand, Roger J.A.

“…C-terminal binding protein (CtBP) has been shown to bind to a highly conserved five-amino-acid motif (PXDLS) located very close to the C-terminus of adenovirus…”
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Detection of CD4+- and CD8+-T-Cell Responses to Human Papillomavirus Type 1 Antigens Expressed at Various Stages of the Virus Life Cycle by Using an Enzyme-Linked Immunospot Assay of Gamma Interferon Release by Steele, Jane C, Roberts, Sally, Rookes, Susan M, Gallimore, Phillip H

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The Replicative Capacities of Large E1B-Null Group A and Group C Adenoviruses Are Independent of Host Cell p53 Status by Turnell, A S, Grand, R J, Gallimore, P H

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The effect of CtBP1 binding on the structure of the C-terminal region of adenovirus 12 early region 1A by Molloy, David P, Barral, Paola M, Gallimore, Phillip H, Grand, Roger J.A

“…Abstract Adenovirus early region 1A (AdE1A) binds to the C-terminal binding protein 1 (CtBP1) primarily through a highly conserved PXDLS motif located close to…”
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Regulation of the 26S proteasome by adenovirus E1A by Turnell, Andrew S., Grand, Roger J.A., Gorbea, Carlos, Zhang, Xian, Wang, Wenlan, Mymryk, Joe S., Gallimore, Phillip H.

“…We have identified the N‐terminus of adenovirus early region 1A (AdE1A) as a region that can regulate the 26S proteasome. Specifically, in vitro and in vivo…”
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The interaction of the hnRNP family member E1B-AP5 with p53 by Barral, Paola M., Rusch, André, Turnell, Andrew S., Gallimore, Phillip H., Byrd, Philip J., Dobner, Thomas, Grand, Roger J.A.

“…Adenovirus early region 1B-associated protein 5, E1B-AP5, a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, was originally isolated on…”
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Human papillomavirus (HPV) type 16‐specific CD8+ T cell responses in women with high grade vulvar intraepithelial neoplasia by Todd, Richard W., Roberts, Sally, Mann, Christopher H., Luesley, David M., Gallimore, Phillip H., Steele, Jane C.

“…Human papillomavirus (HPV)‐associated vulvar intraepithelial neoplasia (VIN) has serious sequelae for the sufferer. Current treatments are associated with poor…”
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Accumulation of p53 in response to adenovirus early region 1A sensitizes human cells to tumor necrosis factor alpha-induced apoptosis by Zhang, Xian, Hussain, Rahel, Turnell, Andrew S., Mymryk, Joe S., Gallimore, Phillip H., Grand, Roger J.A.

“…Many tumor cells are resistant to tumor necrosis factor alpha (TNFα)-induced apoptosis. Adenovirus early region 1A (AdE1A) sensitizes the otherwise resistant…”
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Caspase-Mediated Cleavage of Adenovirus Early Region 1A Proteins by Grand, Roger J.A., Schmeiser, Katja, Gordon, Emma M., Zhang, Xian, Gallimore, Phillip H., Turnell, Andrew S.

“…Adenovirus 2 and 12 early region 1A (Ad2 and Ad12 E1A) proteins were cleaved during cisplatin-induced apoptosis of Ad-transformed rat and human cells. Cleavage…”
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Structural Determinants Present in the C-terminal Binding Protein Binding Site of Adenovirus Early Region 1A Proteins by Molloy, David P., Milner, Anne E., Yakub, Imran K., Chinnadurai, G., Gallimore, Phillip H., Grand, Roger J.A.

“…The C-terminal binding protein (CtBP) has previously been shown to bind to a highly conserved six-amino acid motif very close to the C terminus of adenovirus…”
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Transcriptional regulation of the human glycoprotein hormone common alpha subunit gene by cAMP-response-element-binding protein (CREB)-binding protein (CBP)/p300 and p53 by Zhang, Xian, Grand, Roger J A, McCabe, Christopher J, Franklyn, Jayne A, Gallimore, Phillip H, Turnell, Andrew S

“…We have investigated the functional interactions between adenovirus early region 1A (AdE1A) protein, the co-activators cAMP-response-element-binding protein…”
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Consequences of disruption of the interaction between p53 and the larger adenovirus early region 1B protein in adenovirus E1 transformed human cells by HUTTON, F. G, TURNELL, A. S, GALLIMORE, P. H, GRAND, R. J. A

“…The adenovirus early region 1B (Ad E1B) genes have no transforming capability of their own but markedly increase the transformation frequency of Ad E1A…”
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Definition of a major p53 binding site on Ad2E1B58K protein and a possible nuclear localization signal on the Ad12E1B54K protein by GRAND, R. J. A, PARKHILL, J, SZESTAK, T, ROOKES, S. M, ROBERTS, S, GALLIMORE, P. H

“…Previous studies have established that adenovirus 2/5 early region 1B (Ad E1B) 58K protein binds p53 strongly and co-localizes with it to cytoplasmic dense…”
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