Search Results - "Gallicchio, V S"

Short-Term Treatment with Novel Ribonucleotide Reductase Inhibitors Trimidox and Didox Reverses Late-Stage Murine Retrovirus-Induced Lymphoproliferative Disease with Less Bone Marrow Toxicity Than Hydroxyurea by Mayhew, CN, Phillips, JD, Cibull, ML, Elford, HL, Gallicchio, VS

“…We evaluated the ability of a short course of treatment with the ribonucleotide reductase (RR) inhibitor hydroxyurea (HU) and two novel RR inhibitors Trimidox…”
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Accelerated recovery of hematopoiesis following sub-lethal whole body irradiation with recombinant murine interleukin-1 (IL-1) by Gallicchio, V S

“…This communication reports the results of studies designed to investigate the ability of recombinant murine interleukin-1 (rIL-1) to enhance the recovery of…”
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Modulation of the haematopoietic toxicity associated with zidovudine in vivo with lithium carbonate by Gallicchio, V S, Hughes, N K, Tse, K F

“…The drug zidovudine (AZT), a synthetic thymidine analogue, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of…”
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Failure to establish long-term marrow cultures from immunodeficient mice (MAIDS): effect of zidovudine in vitro by Tse, K F, Hughes, N K, Gallicchio, V S

“…We report here the results of studies examining the ability of zidovudine (AZT) to influence the establishment and maintenance of long-term marrow cultures…”
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Effective modulation of the haematopoietic toxicity associated with zidovudine exposure to murine and human haematopoietic progenitor stem cells in vitro with lithium chloride by Gallicchio, V S, Hughes, N K

“…The drug zidovudine (AZT), a synthetic thymidine analogue, has been used in the treatment of acquired immunodeficiency syndrome (AIDS). Clinical use of…”
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The regulation of phospholipase-A2 (PLA-2) by cytokines expressing hematopoietic growth-stimulating properties by DellaPuca, R, Gallicchio, V S

“…Various growth factors released by macrophages and other cell types modulate normal hematopoiesis. The physiological mechanisms whereby these molecules…”
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Effect of lithium in murine immunodeficiency virus infected animals by Gallicchio, V S, Cibull, M L, Hughes, N K, Tse, K F

“…Murine AIDS (MAIDS) is a disease that shows many similarities to human HIV infection. The etiological agent of MAIDS is a defective murine leukemia virus that…”
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Lithium and hematopoietic toxicity. I. Recovery in vivo of murine hematopoietic stem cells (CFU-S and CFU-Mix) after single-dose administration of cyclophosphamide by Gallicchio, V S

“…Studies are described that demonstrate the ability of lithium (Li) to enhance the recovery of the total peripheral blood neutrophil and pluripotential stem…”
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Effective use of ribonucleotide reductase inhibitors (Didox and Trimidox) alone or in combination with didanosine (ddI) to suppress disease progression and increase survival in murine acquired immunodeficiency syndrome (MAIDS) by Mayhew, C, Oakley, O, Piper, J, Hughes, N K, Phillips, J, Birch, N J, Elford, H L, Gallicchio, V S

“…Ribonucleotide reductase inhibitors (RRIs) have been recently shown to inhibit retroviral replication. We examined a new series of RRIs,…”
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Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells by Gallicchio, V S, Hughes, N K, Hulette, B C, Noblitt, L

“…The drug 3'-azido-3'-deoxythymidine (AZT), a synthetic thymidine analogue, has been used clinically in the management of acquired immune deficiency syndrome…”
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In vitro modulation of the toxicity associated with the use of zidovudine on normal murine, human, and murine retrovirus-infected hematopoietic progenitor stem cells with basic fibroblast growth factor and synergistic activity with interleukin-1 by Gallicchio, V S, Hughes, N K, Hulette, B C

“…The antiviral drug used in the treatment of acquired immunodeficiency syndrome, zidovudine, has proved effective in ameliorating the morbidity and mortality…”
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Stromal Cell Lines Derived From LP-BM5 Murine Leukemia Virus-Infected Long-Term Bone Marrow Cultures Impair Hematopoiesis In Vitro by Tse, Kam-Fai, Morrow, Jennifer K., Hughes, Nedda K., Gallicchio, Vincent S.

“…Murine acquired immunodeficiency syndrome (MAIDS) induced by defective LP-BM5 murine leukemia virus is a disease with many similarities to human AIDS. Previous…”
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In vitro effect of lithium on carbamazepine-induced inhibition of murine and human bone marrow-derived granulocyte-macrophage, erythroid, and megakaryocyte progenitor stem cells by Gallicchio, V S, Hulette, B C

“…Lithium (Li) is a known agent capable of producing leukocytosis, first observed in manic depressive patients receiving Li as therapy; however, a certain…”
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Farnesyltransferase inhibitor (L-744,832) restores TGF-β type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2 by ALCOCK, Rachael A, DEY, Swatee, CHENDIL, Damodaran, INAYAT, Mohammed S, MOHIUDDIN, Mohammed, HARTMAN, George, CHATFIELD, Lee K, GALLICCHIO, Vincent S, AHMED, Mansoor M

“…Activated ras is known to dysregulate TGF-beta signaling by altering the expression of TGF-beta type II receptor (RII). It is well documented that tumor cells…”
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Low dose fractionated radiation enhances the radiosensitization effect of paclitaxel in colorectal tumor cells with mutant p53 by CHENDIL, Damodaran, OAKES, Rachael, ALCOCK, Rachael A, PATEL, Nish, MAYHEW, Christopher, MOHIUDDIN, Mohammed, GALLICCHIO, Vincent S, AHMED, Mansoor M

“…The current study was undertaken to investigate the influence of wild-type or mutant p53 status on the radiosensitizing effect of paclitaxel in colorectal…”
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Influence of lithium on proliferation of hematopoietic stem cells by Gallicchio, V S, Chen, M G

“…We studied the effect of lithium on normal marrow hematopoiesis by determining the numbers of pluripotential (CFUS) and committed stem cells (CFUC, CFUE and…”
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Combination of inhibitors of lymphocyte activation (hydroxyurea, trimidox, and didox) and reverse transcriptase (didanosine) suppresses development of murine retrovirus-induced lymphoproliferative disease by Mayhew, Christopher N., Sumpter, Ryan, Inayat, Mohammed, Cibull, Michael, Phillips, Jonathan D., Elford, Howard L., Gallicchio, Vincent S.

“…The ribonucleotide reductase inhibitor hydroxyurea (HU) has demonstrated some benefit as a component of drug cocktails for the treatment of HIV-1 infection…”
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Increased lethality of calmodulin antagonists and bleomycin to human bone marrow and bleomycin-resistant malignant cells by LAZO, J. S, CHEN, D.-L, GALLICCHIO, V. S, HAIT, W. N

“…The effect of bleomycin and calmodulin antagonists on human cells was studied using a clonogenic assay. A 1-h exposure to nontoxic concentrations of the…”
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Prevention of the hematopoietic toxicity associated with zidovudine in vivo with IL-1 alone or in combination with GM-CSF administered to normal mice by Gallicchio, V S, Hughes, N K, Tse, K F, Gaines, H

“…We studied the effect of interleukin-1 (IL-1 alpha) either alone or administered with GM-CSF on the induction of hematopoietic toxicity associated with…”
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Reconstitution of erythroid, megakaryocyte and myeloid hematopoietic support function with neutralizing antibodies against IL-4 and TGF beta 1 in long-term bone marrow cultures infected with LP-BM5 murine leukemia virus by Tse, K F, Inayat, MS, Morrow, J K, Hughes, N K, Oakley, O R, Gallicchio, V S

“…Murine acquired immunodeficiency syndrome (MAIDS) induced by a defective LP-BM5 murine leukemia virus (MuLV) produces hematopoietic cytopenias similar to HIV…”
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