Search Results - "Galli, Carmela"

N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation by Fregno, Ilaria, Fasana, Elisa, Soldà, Tatiana, Galli, Carmela, Molinari, Maurizio

“…Efficient degradation of by‐products of protein biogenesis maintains cellular fitness. Strikingly, the major biosynthetic compartment in eukaryotic cells, the…”
Get full text

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery by Fumagalli, Fiorenza, Noack, Julia, Bergmann, Timothy J., Cebollero, Eduardo, Pisoni, Giorgia Brambilla, Fasana, Elisa, Fregno, Ilaria, Galli, Carmela, Loi, Marisa, Soldà, Tatiana, D’Antuono, Rocco, Raimondi, Andrea, Jung, Martin, Melnyk, Armin, Schorr, Stefan, Schreiber, Anne, Simonelli, Luca, Varani, Luca, Wilson-Zbinden, Caroline, Zerbe, Oliver, Hofmann, Kay, Peter, Matthias, Quadroni, Manfredo, Zimmermann, Richard, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the…”
Get full text

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates by Bernasconi, Riccardo, Galli, Carmela, Calanca, Verena, Nakajima, Toshihiro, Molinari, Maurizio

“…Sophisticated quality control mechanisms prolong retention of protein-folding intermediates in the endoplasmic reticulum (ER) until maturation while sorting…”
Get full text

TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress by Kucińska, Marika K., Fedry, Juliette, Galli, Carmela, Morone, Diego, Raimondi, Andrea, Soldà, Tatiana, Förster, Friedrich, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is an organelle of nucleated cells that produces proteins, lipids and oligosaccharides. ER volume and activity are increased…”
Get full text

Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities by Calì, Tito, Galli, Carmela, Olivari, Silvia, Molinari, Maurizio

“…EDEM1 is a crucial regulator of endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts non-native glycopolypeptides from the calnexin chaperone…”
Get full text

Malectin participates in a backup glycoprotein quality control pathway in the mammalian ER by Galli, Carmela, Bernasconi, Riccardo, Soldà, Tatiana, Calanca, Verena, Molinari, Maurizio

“…Malectin is a conserved, endoplasmic reticulum (ER)-resident lectin that recognizes high mannose oligosaccharides displaying terminal glucose residues. Here we…”
Get full text

Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle by Molinari, Maurizio, Calanca, Verena, Galli, Carmela, Lucca, Paola, Paganetti, Paolo

“…The mechanisms that determine how folding attempts are interrupted to target folding-incompetent proteins for endoplasmic reticulum-associated degradation…”
Get full text

Decoding Seafood: Multi-Marker Metabarcoding for Authenticating Processed Seafood by Mottola, Anna, Piredda, Roberta, Lorusso, Lucilia, Ranieri, Lucia, Intermite, Chiara, Barresi, Concettina, Galli, Carmela, Di Pinto, Angela

“…Given the recognized nutritional value of fish and shifting consumer lifestyles, processed seafood has become increasingly prevalent, comprising a significant…”
Get full text

Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation by Bernasconi, Riccardo, Soldà, Tatiana, Galli, Carmela, Pertel, Thomas, Luban, Jeremy, Molinari, Maurizio

“…Peptidyl-prolyl cis/trans isomerases (PPIs) catalyze cis/trans isomerization of peptide bonds preceding proline residues. The involvement of PPI family members…”
Get full text

RETRACTED: Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway by Bernasconi, Riccardo, Galli, Carmela, Kokame, Koichi, Molinari, Maurizio

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
Get full text

Endoplasmic Reticulum and Lysosomal Quality Control of Four Nonsense Mutants of Iduronate 2-Sulfatase Linked to Hunter's Syndrome by Marazza, Alessandro, Galli, Carmela, Fasana, Elisa, Sgrignani, Jacopo, Burda, Patricie, Fassi, Enrico M A, Baumgartner, Matthias, Cavalli, Andrea, Molinari, Maurizio

“…Hunter's syndrome (mucopolysaccharidosis type II) is a rare X-linked lysosomal storage disorder caused by mutations in the iduronate-2-sulfatase (IDS) gene…”
Get more information

A Novel Stress-induced EDEM Variant Regulating Endoplasmic Reticulum-associated Glycoprotein Degradation by Olivari, Silvia, Galli, Carmela, Alanen, Heli, Ruddock, Lloyd, Molinari, Maurizio

“…Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control. Persistent association with ER-resident molecular chaperones…”
Get full text

Contrasting Functions of Calreticulin and Calnexin in Glycoprotein Folding and ER Quality Control by Molinari, Maurizio, Eriksson, Klara Kristin, Calanca, Verena, Galli, Carmela, Cresswell, Peter, Michalak, Marek, Helenius, Ari

“…Calreticulin and calnexin are homologous lectins that serve as molecular chaperones for glycoproteins in the endoplasmic reticulum of eukaryotic cells. Here we…”
Get full text

Sequential Assistance of Molecular Chaperones and Transient Formation of Covalent Complexes during Protein Degradation from the ER by Molinari, Maurizio, Galli, Carmela, Piccaluga, Verena, Pieren, Michel, Paganetti, Paolo

“…BACE457 is a recently identified pancreatic isoform of human β-secretase. We report that this membrane glycoprotein and its soluble variant are characterized…”
Get full text

Persistent Glycoprotein Misfolding Activates the Glucosidase II/UGT1-Driven Calnexin Cycle to Delay Aggregation and Loss of Folding Competence by Molinari, Maurizio, Galli, Carmela, Vanoni, Omar, Arnold, Stacey M., Kaufman, Randal J.

“…The UDP-glucose:glycoprotein glucosyltransferase (UGT) is a central player of glycoprotein quality control in the endoplasmic reticulum (ER). UGT…”
Get full text

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool by Marroquin Belaunzaran, Osiris, Cordero, Maria Isabel, Setola, Veronica, Bianchi, Siro, Galli, Carmela, Bouche, Nicolas, Mlynarik, Vladimir, Gruetter, Rolf, Sandi, Carmen, Bensadoun, Jean-Charles, Molinari, Maurizio, Aebischer, Patrick

“…Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional…”
Get full text

The Use of Calnexin and Calreticulin by Cellular and Viral Glycoproteins by Pieren, Michel, Galli, Carmela, Denzel, Angela, Molinari, Maurizio

“…Calnexin and calreticulin are homologous lectin chaperones that assist maturation of cellular and viral glycoproteins in the mammalian endoplasmic reticulum…”
Get full text

RETRACTED: Role of the SEL1L:LC3-I Complex as an ERAD Tuning Receptor in the Mammalian ER by Bernasconi, Riccardo, Galli, Carmela, Noack, Julia, Bianchi, Siro, de Haan, Cornelis A.M., Reggiori, Fulvio, Molinari, Maurizio

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
Get full text

Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA by Molinari, M, Salio, M, Galli, C, Norais, N, Rappuoli, R, Lanzavecchia, A, Montecucco, C

“…A major virulence factor in the stomach chronic infection by Helicobacter pylori is a protein toxin (VacA), which alters cell membrane trafficking of late…”
Get full text

Vacuoles Induced by Helicobacter pylori Toxin Contain Both Late Endosomal and Lysosomal Markers by Molinari, Maurizio, Galli, Carmela, Norais, Nathalie, Telford, John L., Rappuoli, Rino, Luzio, J. Paul, Montecucco, Cesare

“…Intoxication of mammalian cells with the vacuolating toxin (VacA) released by Helicobacter pyloricauses the formation of large acidic vacuoles containing the…”
Get full text