Search Results - "Galley, Helen"

Bench-to-bedside review: Targeting antioxidants to mitochondria in sepsis by Galley, Helen F

“…Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal…”
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Melatonin limits paclitaxel‐induced mitochondrial dysfunction in vitro and protects against paclitaxel‐induced neuropathic pain in the rat by Galley, Helen F., McCormick, Barry, Wilson, Kirsten L., Lowes, Damon A., Colvin, Lesley, Torsney, Carole

“…Chemotherapy‐induced neuropathic pain is a debilitating and common side effect of cancer treatment. Mitochondrial dysfunction associated with oxidative stress…”
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Domestic violence and perinatal mental disorders: a systematic review and meta-analysis by Howard, Louise M, Oram, Sian, Galley, Helen, Trevillion, Kylee, Feder, Gene

“…Domestic violence in the perinatal period is associated with adverse obstetric outcomes, but evidence is limited on its association with perinatal mental…”
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Melatonin and Related Compounds: Antioxidant and Anti-Inflammatory Actions by Bantounou, Maria, Plascevic, Josip, Galley, Helen F

“…Melatonin, an indoleamine derived from tryptophan and produced in the pineal gland and other tissues [...]…”
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Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis by Galley, Helen F., Lowes, Damon A., Allen, Lee, Cameron, Gary, Aucott, Lorna S., Webster, Nigel R.

“…Sepsis is a massive inflammatory response mediated by infection, characterized by oxidative stress, release of cytokines, and mitochondrial dysfunction…”
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Lack of compliance with mandatory clinical trial registration by Docherty, Ronan M, Galley, Helen F

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The effect of Preoperative threshold inspiratory muscle training in adults undergoing cardiac surgery on postoperative hospital stay: a systematic review by Cook, Adele, Smith, Laura, Anderson, Callum, Ewing, Nicole, Gammack, Ashley, Pecover, Mark, Sime, Nicole, Galley, Helen F.

“…Systematic reviews have reported benefits of preoperative inspiratory muscle training in adults undergoing cardiac surgery, however there have been…”
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Melatonin treatment has consistent but transient beneficial effects on sleep measures and pain in patients with severe chronic pain: the DREAM-CP randomised controlled trial by Onyeakazi, Uzunma M, Columb, Malachy O, Rosalind, Adam, Kanakarajan, Saravanakumar, Galley, Helen F

“…Sleep disturbance is a major issue for patients with chronic pain. Melatonin has been shown to improve symptoms of fibromyalgia, but its efficacy in other…”
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Deep anaesthesia and poor outcomes: the jury is still out by Galley, Helen F, Webster, Nigel R

“…The ideal anaesthetic depth is where the risk of operative recall or awareness is as low as possible, regardless of what is happening surgically, and where…”
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Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis by Galley, Helen F., Allen, Lee, Colin, Pieter J., Galt, Sally P., Webster, Nigel R.

“…Sepsis is defined as a dysregulated host response to infection, and high‐dose melatonin has been proposed as a treatment due to its antioxidant and…”
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The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis by Lowes, Damon A., Thottakam, Bensita M.V., Webster, Nigel R., Murphy, Michael P., Galley, Helen F.

“…Sepsis is characterised by a systemic dysregulated inflammatory response and oxidative stress, often leading to organ failure and death. Development of organ…”
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Extent of sleep problems and relationship with severity of chronic pain using three validated sleep assessment tools by Vaughan, Rachel, Galley, Helen F, Kanakarajan, Saravana

“…Objective Chronic pain can impact on sleep, but the extent and nature of sleep problems in patients with chronic pain are incompletely clear. Several validated…”
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Maternal Serum Melatonin Increases During Pregnancy and Falls Immediately After Delivery Implicating the Placenta as a Major Source of Melatonin by Ejaz, Haroon, Figaro, Juliana K, Woolner, Andrea M F, Thottakam, Bensita M V, Galley, Helen F

“…Melatonin is a neuroendocrine hormone which regulates circadian rhythm and is also an antioxidant. The role of melatonin in pregnancy is emerging. The enzymes…”
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Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis by Lowes, Damon A, Galley, Helen F

“…Oxidative stress and mitochondrial dysfunction are common features in patients with sepsis and organ failure. Within mitochondria, superoxide is converted into…”
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Can soluble urokinase plasminogen receptor predict outcomes after cardiac surgery? by Schultz-Swarthfigure, Chase T, McCall, Philip, Docking, Robert, Galley, Helen F, Shelley, Benjamin

“…Abstract OBJECTIVES Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that has been implicated in several cardiac pathologies and has…”
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Enfortumab vedotin and pembrolizumab as monotherapies and combination treatment in locally advanced or metastatic urothelial carcinoma: A narrative review by Bantounou, Maria A., Plascevic, Josip, MacDonald, Lewis, Wong, Man Chun, O'Connell, Neasa, Galley, Helen F.

“…BackgroundBladder cancer is the 10th most common cancer globally. The majority of bladder cancers are urothelial carcinomas (UCs), which, if locally advanced…”
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Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM—CP): a study protocol by Adam, Rosalind, Kanakarajan, Saravanakumar, Onyeakazi, Uzunma, Columb, Malachy, Galley, Helen

“…IntroductionChronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance. Exogenous melatonin is licensed to…”
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Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis by Minter, Beverley E, Lowes, Damon A, Webster, Nigel R, Galley, Helen F

“…Sepsis is a life-threatening response to infection associated with inflammation, oxidative stress and mitochondrial dysfunction. We investigated differential…”
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Melatonin Is a Feasible, Safe, and Acceptable Intervention in Doctors and Nurses Working Nightshifts: The MIDNIGHT Trial by Thottakam, Bensita M. V. J., Webster, Nigel R., Allen, Lee, Columb, Malachy O., Galley, Helen F.

“…Nightshift working is associated with sleep deprivation, fatigue and attention/concentration deficits which, in healthcare workers, may impact on patient…”
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Supraneural versus Infraneural Approach to transforaMinal Epidural StEroid injection for unilateral lumbosacral radicular pain (SIAMESE): a study protocol for a randomised non-inferiority trial by Galley, Helen F., Adam, Rosalind, Columb, Malachy O., Onyeakazi, Uzunma M., Kanakarajan, Saravanakumar

“…Lumbosacral radicular pain is commonly treated by transforaminal steroid epidural injection. There are two methods: the supraneural and the infraneural…”
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