Search Results - "Gallego, Rebecca A."

Lipophilic Efficiency as an Important Metric in Drug Design by Johnson, Ted W, Gallego, Rebecca A, Edwards, Martin P

“…Lipophilic efficiency (LipE) is an important metric that has been increasingly applied in drug discovery medicinal chemistry lead optimization programs. In…”
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Reviving B‑Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase by Johnson, Ted W, Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A, Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei

“…Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that can become oncogenic by activating mutations or overexpression. Full kinetic…”
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An update on lipophilic efficiency as an important metric in drug design by Gallego, Rebecca A, Edwards, Martin P, Montgomery, T Patrick

“…Lipophilic efficiency (LipE) and lipophilic metabolic efficiency (LipMetE) are valuable tools that can be utilized as part of a multiparameter optimization…”
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Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation by Johnson, Eric, McTigue, Michele, Gallego, Rebecca A., Johnson, Ted W., Timofeevski, Sergei, Maestre, Michael, Fisher, Timothy S., Kania, Robert, Sawasdikosol, Sansana, Burakoff, Steven, Cronin, Ciarán N.

“…Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a Ser/Thr kinase that operates via the c-Jun N-terminal kinase (JNK) and extracellular signal-regulated…”
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Design and Synthesis of Functionally Active 5‑Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1 by Gallego, Rebecca A., Bernier, Louise, Chen, Hui, Cho-Schultz, Sujin, Chung, Loanne, Collins, Michael, Del Bel, Matthew, Elleraas, Jeff, Costa Jones, Cinthia, Cronin, Ciaran N., Edwards, Martin, Fang, Xu, Fisher, Timothy, He, Mingying, Hoffman, Jacqui, Huo, Ruiduan, Jalaie, Mehran, Johnson, Eric, Johnson, Ted W., Kania, Robert S., Kraus, Manfred, Lafontaine, Jennifer, Le, Phuong, Liu, Tongnan, Maestre, Michael, Matthews, Jean, McTigue, Michele, Miller, Nichol, Mu, Qiming, Qin, Xulong, Ren, Shijian, Richardson, Paul, Rohner, Allison, Sach, Neal, Shao, Li, Smith, Graham, Su, Ruirui, Sun, Bin, Timofeevski, Sergei, Tran, Phuong, Wang, Shuiwang, Wang, Wei, Zhou, Ru, Zhu, Jinjiang, Nair, Sajiv K.

“…Immune activating agents represent a valuable class of therapeutics for the treatment of cancer. An area of active research is expanding the types of these…”
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Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL) by Gallego, Rebecca A., Scales, Stephanie, Toledo, Chad, Auth, Marin, Bernier, Louise, Berry, Madeline, Brun, Sonja, Chung, Loanne, Davis, Carl, Diehl, Wade, Dress, Klaus, Eisele, Koleen, Elleraas, Jeff, Ewanicki, Jason, Fobian, Yvette, Greasley, Samantha, Greenwald, Eric C., Johnson, Ted W., Khamphavong, Penney, Lafontaine, Jennifer, Li, Jian, Linton, Angelica, Maestre, Michael, Miller, Nichol, Murtaza, Anwar, Patman, Ryan L., Quinlan, Casey L., Ramms, Dana J., Richardson, Paul, Sach, Neal, Salomon-Ferrer, Romelia, Silva, Francisco, Timofeevski, Sergei, Tran, Phuong, Tran-Dubé, Michelle, Wang, Fen, Wang, Wei, Wythes, Martin, Yang, Shouliang, Zou, Aihua, VanArsdale, Todd, McAlpine, Indrawan

“…By virtue of its role in cellular proliferation, microtubule-associated serine/threonine kinase-like (MASTL) represents a novel target and a first-in-class…”
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Reviving B‑Factors: Retrospective Normalized B‑Factor Analysis of c‑ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib by Johnson, Ted W, Gallego, Rebecca A, Brooun, Alexei, Gehlhaar, Dan, McTigue, Michele

“…Structure-based drug design (SBDD) is commonly leveraged in rational drug design. Usually, ligand and binding site atomic coordinates from crystallographic…”
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Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase by Johnson, Ted W., Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A., Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei

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