Search Results - "Gallea, José Ignacio"
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Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease
Published in Biochemical journal (01-11-2015)“…Parkinson's disease (PD) is an age-related movement disorder characterized by a progressive degeneration of dopaminergic neurons in the midbrain. Although the…”
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Single-Molecule Fluorescence Lifetime Imaging Using Wide-Field and Confocal-Laser Scanning Microscopy: A Comparative Analysis
Published in Nano letters (10-08-2022)“…A recent addition to the toolbox of super-resolution microscopy methods is fluorescence-lifetime single-molecule localization microscopy (FL-SMLM). The synergy…”
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Work-Related Mental Health Issues in Graduate Student Population
Published in Frontiers in neuroscience (01-04-2021)“…The scientific and educational community is becoming increasingly aware of the impact of current academic working conditions on graduate students' mental…”
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Doubling the resolution of fluorescence-lifetime single-molecule localization microscopy with image scanning microscopy
Published in Nature photonics (01-10-2024)“…In this study, we integrate a single-photon detector array into a confocal laser scanning microscope, enabling the combination of fluorescence-lifetime…”
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Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death
Published in Scientific reports (03-03-2017)“…Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of their cytoplasm for removal or turnover. Neurodegenerative…”
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Amyloid oligomerization of the Parkinson's disease related protein α‐synuclein impacts on its curvature‐membrane sensitivity
Published in Journal of neurochemistry (01-11-2018)“…The amyloid aggregation of the presynaptic protein α‐synuclein (AS) is pathognomonic of Parkinson's disease and other neurodegenerative disorders…”
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