Search Results - "Galle, Jesse"
-
1
Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer
Published in Journal of clinical oncology (01-02-2019)“…Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing has traditionally been performed in patients with colorectal (CRC) and…”
Get full text
Journal Article -
2
Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing
Published in JAMA : the journal of the American Medical Association (05-09-2017)“…IMPORTANCE: Guidelines for cancer genetic testing based on family history may miss clinically actionable genetic changes with established implications for…”
Get full text
Journal Article -
3
Therapeutic Implications of Germline Testing in Patients With Advanced Cancers
Published in Journal of clinical oncology (20-08-2021)“…Tumor mutational profiling is increasingly performed in patients with advanced cancer. We determined the extent to which germline mutation profiling guides…”
Get full text
Journal Article -
4
A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers
Published in JNCI : Journal of the National Cancer Institute (29-11-2021)“…The causative factors for the recent increase in early-onset colorectal cancer (EO-CRC) incidence are unknown. We sought to determine if early-onset disease is…”
Get full text
Journal Article -
5
The context-specific role of germline pathogenicity in tumorigenesis
Published in Nature genetics (01-11-2021)“…Human cancers arise from environmental, heritable and somatic factors, but how these mechanisms interact in tumorigenesis is poorly understood. Studying 17,152…”
Get full text
Journal Article -
6
Abstract PO-034: A collaborative approach to increase germline testing and counseling uptake within New York City’s underserved patient population
Published in Cancer epidemiology, biomarkers & prevention (01-12-2020)“…Abstract Background: Understanding the role of genetic drivers in cancer is a fundamental component of precision medicine. Further, identification of germline…”
Get full text
Journal Article -
7
MSK eConsent: Digitalizing the informed consent process to improve participant engagement and understanding
Published in Journal of clinical oncology (20-05-2020)“…Abstract only 2066 Background: eConsent was developed to digitize the research participant consenting experience with an educational engagement model. The…”
Get full text
Journal Article -
8
Abstract A090: Community partnerships expand access to tumor molecular profiling
Published in Cancer epidemiology, biomarkers & prevention (01-06-2020)“…Abstract Background: In oncology, the promise of precision medicine relies fundamentally on the identification of genetic mutations that can be targeted…”
Get full text
Journal Article -
9
Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach
Published in Clinical cancer research (05-07-2023)“…To overcome barriers to genomic testing for patients with rare cancers, we initiated a program to offer free clinical tumor genomic testing worldwide to…”
Get full text
Journal Article -
10
Abstract 1122: Germline mutation prevalence in young adults with cancer
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract The identification of germline pathogenic variants in young adult cancer patients is especially critical given risk of second primary cancers, need…”
Get full text
Journal Article -
11
Abstract 375: Oncologist use and perception of large panel next generation tumor sequencing
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Abstract At Memorial Sloan Kettering, we have used a clinically validated custom hybridization capture-based NGS assay (MSK-IMPACT) to sequence the tumors of…”
Get full text
Journal Article