Search Results - "Gallaschun, R J"

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships by Schnur, R C, Corman, M L, Gallaschun, R J, Cooper, B A, Dee, M F, Doty, J L, Muzzi, M L, DiOrio, C I, Barbacci, E G, Miller, P E

“…Overexpression of the erbB-2 oncogene has been linked to poor prognosis in breast, ovarian, and gastric cancers. Naturally occurring benzoquinoid ansamycin…”
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Synthesis and Oral Efficacy of a 4-(Butylethylamino)pyrrolo[2,3-d]pyrimidine:  A Centrally Active Corticotropin-Releasing Factor1 Receptor Antagonist by Chen, Yuhpyng L, Mansbach, Robert S, Winter, Steven M, Brooks, Elizabeth, Collins, Judith, Corman, Michael L, Dunaiskis, Audrey R, Faraci, W. Stephen, Gallaschun, Randall J, Schmidt, Anne, Schulz, David W

“…The syntheses of a centrally active nonpeptide CRF1 receptor antagonist 2,…”
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Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives by Schnur, R. C, Corman, M. L, Gallaschun, R. J, Cooper, B. A, Dee, M. F, Doty, J. L, Muzzi, M. L, Moyer, J. D, DiOrio, C. I

“…The erbB-2 oncogene encodes a transmembrane protein tyrosine kinase which plays a pivotal role in signal transduction and has been implicated when…”
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Quantitative structure-activity relationships of antitumor guanidinothiazolecarboxamides with survival enhancement for therapy in the 3LL Lewis lung carcinoma model by Schnur, Rodney C, Gallaschun, Randall J, Singleton, David H, Grissom, Martin, Sloan, Donald E, Goodwin, Peter, McNiff, Patricia A, Fliri, Anton F. J, Mangano, F. Michael

“…Guanidinothiazolecarboxamides (GTCs) are a novel class of antitumor agents found to be systemically active against experimental pulmonary metastases of 3LL…”
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erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships by Schnur, R. C, Corman, M. L, Gallaschun, R. J, Cooper, B. A, Dee, M. F, Doty, J. L, Muzzi, M. L, DiOrio, C I, Barbacci, E. G

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Synthesis of novel 1H-imidazo[5,1-B][3]benzazepine-1,3(2H)-dione and pyrimido[6,1-B][3]benzazepine-1,3,4(2H)-trione by Gallaschun, Randall J., Schnur, Rodney C.

“…Two novel tricyclic ring systems derived from 3‐benzazepines were synthesized; the first, a 6,7,5‐ring, 1H‐imidazo[5,1‐b][3]benzazepine‐1,3(2H)‐dione was…”
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Synthesis of 1,2-dihydro-1-oxo-3H-3benzazepine and 3-acyl derivatives by SCHNUR, R. C, GALLASCHUN, R. J

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Inhibition of the oncogene product p185 super(erbB-2) in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives by Schnur, R C, Corman, M L, Gallaschun, R J, Cooper, BA, Dee, M F, Doty, J L, Muzzi, M L, Moyer, J D, DiOrio, C I, Barbacci, E G, Miller, P E, O'Brien, A T, Morin, MJ, Foster, BA, Pollack, V A

“…The erbB-2 oncogene encodes a transmembrane protein tyrosine kinase which plays a pivotal role in signal transduction and has been implicated when…”
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Quantitative structure-activity relationships of antitumor guanidinothiazole-carboxamides with survival enhancement for therapy in the 3LL Lewis lung carcinoma model by Schnur, R C, Gallaschun, R J, Singleton, D H, Grissom, M, Sloan, DE, Goodwin, P, McNiff, P A, Fliri, AFJ, Pollack, V A

“…Guanidinothiazole-carboxamides (GTCs) are a novel class of antitumor agents found to be systemically active against experimental pulmonary metastases of 3LL…”
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Synthesis of novel 1,3-oxazino[6,5-b]indole-2,4-(3H,9H)-dione and 2H-1,3,5-oxadiazino[3,2-a]indole-2,4-(3H)-dione from oxindoles by Gallaschun, Randall J., Schnur, Rodney C.

“…Two novel tricyclic ring systems were designed as serine protease inhibitors and synthesized from oxindoles; the first series,…”
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Synthesis of 1,2-dihydro-1-oxo-3H-3-benzazepine and 3-acyl derivatives by Schnur, Rodney C, Gallaschun, Randall J

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