Inflammatory mechanisms of preterm labor and emerging anti-inflammatory interventions

Inflammatory mechanisms of preterm labor and emerging anti-inflammatory interventions

Preterm birth is a major public health concern, requiring a deeper understanding of its underlying inflammatory mechanisms and to develop effective therapeutic strategies. This review explores the complex interaction between inflammation and preterm labor, highlighting the pivotal role of the dysreg...

Full description

Saved in:
Bibliographic Details
Published in:Cytokine & growth factor reviews Vol. 78; pp. 50 - 63
Main Authors: Habelrih, Tiffany, Augustin, Thalyssa-Lyn, Mauffette-Whyte, Félix, Ferri, Béatrice, Sawaya, Kevin, Côté, France, Gallant, Mathilde, Olson, David M., Chemtob, Sylvain
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-08-2024
Subjects:
Anti-inflammatory
Inflammation
Preterm birth
Preterm labor
Therapeutics
HMGB
OXTR
CSAIDs
Preterm birth
COX-2
UAP
PTL
IL-R
AP-1
LRR
LPS
DAMPs
HPV
PRR
BSCIs
NF-ĸB
Th
HHV
GBS
TLR
NBDI
CAMP
IL
MLCK
TPCA-1
P4
Treg
Preterm labor
PKC
Inflammation
MAPK
IP3
IL-1RAcP
MMP
NAC
PAMP
PG
Therapeutics
LTA
SSTR
GPCR
PPROM
TIR
NK
Anti-inflammatory
OxZnl
PTB
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preterm birth is a major public health concern, requiring a deeper understanding of its underlying inflammatory mechanisms and to develop effective therapeutic strategies. This review explores the complex interaction between inflammation and preterm labor, highlighting the pivotal role of the dysregulation of inflammation in triggering premature delivery. The immunological environment of pregnancy, characterized by a fragile balance of immune tolerance and resistance, is disrupted in preterm labor, leading to a pathological inflammatory response. Feto-maternal infections, among other pro-inflammatory stimuli, trigger the activation of toll-like receptors and the production of pro-inflammatory mediators, promoting uterine contractility and cervical ripening. Emerging anti-inflammatory therapeutics offer promising approaches for the prevention of preterm birth by targeting key inflammatory pathways. From TLR-4 antagonists to chemokine and interleukin receptor antagonists, these interventions aim to modulate the inflammatory environment and prevent adverse pregnancy outcomes. In conclusion, a comprehensive understanding of the inflammatory mechanisms leading to preterm labor is crucial for the development of targeted interventions in hope of reducing the incidence of preterm birth and improving neonatal health outcomes. [Display omitted] •Preterm labor pathways are initiated and maintained by inflammation.•Inhibiting the inflammatory response associated to preterm labor with emerging anti-inflammatory therapeutics shows promise in preventing preterm birth.•The collaboration between regulatory institutions, clinicians, advocates, and researchers is necessary to bring awareness to this unmet medical need and to develop effective therapeutics destined to prevent preterm birth.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2024.07.007