Search Results - "Gallant, Caroline J"

Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99 by Mattisson, Jonas, Danielsson, Marcus, Hammond, Maria, Davies, Hanna, Gallant, Caroline J., Nordlund, Jessica, Raine, Amanda, Edén, Malin, Kilander, Lena, Ingelsson, Martin, Dumanski, Jan P., Halvardson, Jonatan, Forsberg, Lars A.

“…Mosaic loss of chromosome Y (LOY) in immune cells is a male-specific mutation associated with increased risk for morbidity and mortality. The CD99 gene,…”
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A combined approach for single-cell mRNA and intracellular protein expression analysis by Reimegård, Johan, Tarbier, Marcel, Danielsson, Marcus, Schuster, Jens, Baskaran, Sathishkumar, Panagiotou, Styliani, Dahl, Niklas, Friedländer, Marc R., Gallant, Caroline J.

“…Combined measurements of mRNA and protein expression in single cells enable in-depth analysis of cellular states. We present SPARC, an approach that combines…”
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Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells by Tarbier, Marcel, Mackowiak, Sebastian D., Frade, João, Catuara-Solarz, Silvina, Biryukova, Inna, Gelali, Eleni, Menéndez, Diego Bárcena, Zapata, Luis, Ossowski, Stephan, Bienko, Magda, Gallant, Caroline J., Friedländer, Marc R.

“…Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the…”
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Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis by Cobat, Aurelie, Gallant, Caroline J, Simkin, Leah, Black, Gillian F, Stanley, Kim, Hughes, Jane, Doherty, T Mark, Hanekom, Willem A, Eley, Brian, Jaïs, Jean-Philippe, Boland-Auge, Anne, van Helden, Paul, Casanova, Jean-Laurent, Abel, Laurent, Hoal, Eileen G, Schurr, Erwin, Alcaïs, Alexandre

“…Approximately 20% of persons living in areas hyperendemic for tuberculosis (TB) display persistent lack of tuberculin skin test (TST) reactivity and appear to…”
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High Heritability of Antimycobacterial Immunity in an Area of Hyperendemicity for Tuberculosis Disease by Cobat, Aurelie, Gallant, Caroline J., Simkin, Leah, Black, Gillian F., Stanley, Kim, Hughes, Jane, Mark Doherty, T., Hanekom, Willem A., Eley, Brian, Beyers, Nulda, Jaïs, Jean-Philippe, van Helden, Paul, Abel, Laurent, Hoal, Eileen G., Alcaïs, Alexandre, Schurr, Erwin

“…Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report…”
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A compendium on single‐cell analysis for the curious by Gallant, Caroline J., Landegren, Ulf

“…Single‐cell analysis is impacting biology and medicine by changing the scale and resolution at which we investigate multicellular organisms. A particular,…”
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Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction by Genshaft, Alex S, Li, Shuqiang, Gallant, Caroline J, Darmanis, Spyros, Prakadan, Sanjay M, Ziegler, Carly G K, Lundberg, Martin, Fredriksson, Simon, Hong, Joyce, Regev, Aviv, Livak, Kenneth J, Landegren, Ulf, Shalek, Alex K

“…We present a scalable, integrated strategy for coupled protein and RNA detection from single cells. Our approach leverages the DNA polymerase activity of…”
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Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout by Al-Amin, Rasel A, Gallant, Caroline J, Muthelo, Phathutshedzo M, Landegren, Ulf

“…The ability to monitor target engagement in cellular contexts is a key for successful drug discovery and also valuable in clinical routine. A cellular thermal…”
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Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays by Larssen, Pia, Wik, Lotta, Czarnewski, Paulo, Eldh, Maria, Löf, Liza, Ronquist, K. Göran, Dubois, Louise, Freyhult, Eva, Gallant, Caroline J., Oelrich, Johan, Larsson, Anders, Ronquist, Gunnar, Villablanca, Eduardo J., Landegren, Ulf, Gabrielsson, Susanne, Kamali-Moghaddam, Masood

“…Extracellular vesicles (EVs) are membrane-coated objects such as exosomes and microvesicles, released by many cell-types. Their presence in body fluids and the…”
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Identification of a Major Locus, TNF1, That Controls BCG-Triggered Tumor Necrosis Factor Production by Leukocytes in an Area Hyperendemic for Tuberculosis by Cobat, Aurelie, Hoal, Eileen G., Gallant, Caroline J., Simkin, Leah, Black, Gillian F., Stanley, Kim, Jaïs, Jean-Philippe, Yu, Ting-Heng, Boland-Auge, Anne, Grange, Ghislain, Delacourt, Christophe, van Helden, Paul, Casanova, Jean-Laurent, Abel, Laurent, Alcaïs, Alexandre, Schurr, Erwin

“…Background. Tumor necrosis factor (TNF) is a key immune regulator of tuberculosis resistance, as exemplified by the highly increased risk of tuberculosis…”
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Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays by Larssen, Pia, Wik, Lotta, Czarnewski, Paulo, Eldh, Maria, Löf, Liza, Ronquist, K. Göran, Dubois, Louise, Freyhult, Eva, Gallant, Caroline J., Oelrich, Johan, Larsson, Anders, Ronquist, Gunnar, Villablanca, Eduardo J., Landegren, Ulf, Gabrielsson, Susanne, Kamali-Moghaddam, Masood

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Tuberculin skin test and in vitro assays provide complementary measures of antimycobacterial immunity in children and adolescents by Gallant, Caroline J, Cobat, Aurelie, Simkin, Leah, Black, Gillian F, Stanley, Kim, Hughes, Jane, Doherty, T Mark, Hanekom, Willem A, Eley, Brian, Beyers, Nulda, Jaïs, Jean-Philippe, van Helden, Paul, Abel, Laurent, Alcaïs, Alexandre, Hoal, Eileen G, Schurr, Erwin

“…Although many studies have compared in vitro TB diagnostic tests with the venerable tuberculin skin test (TST), there is little understanding of the…”
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Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells by Batool, Tahira, Fang, Jianping, Jansson, Viktor, Zhao, Hongxing, Gallant, Caroline, Moustakas, Aristidis, Li, Jin-Ping

“…Glucuronyl C5-epimerase (Hsepi) catalyzes the conversion of glucuronic acid to iduronic acid in the process of heparan sulfate biosynthesis. Targeted…”
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ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function by Schuster, Jens, Klar, Joakim, Khalfallah, Ayda, Laan, Loora, Hoeber, Jan, Fatima, Ambrin, Sequeira, Velin Marita, Jin, Zhe, Korol, Sergiy V., Huss, Mikael, Nordgren, Ann, Anderlid, Britt Marie, Gallant, Caroline, Birnir, Bryndis, Dahl, Niklas

“…Mowat-Wilson syndrome (MWS) is a severe neurodevelopmental disorder caused by heterozygous variants in the gene encoding transcription factor ZEB2 . Affected…”
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Susceptibility to leprosy is associated with PARK2 and PACRG by Abel, Laurent, Schurr, Erwin, Mira, Marcelo T, Alcaïs, Alexandre, Van Thuc, Nguyen, Moraes, Milton O, Di Flumeri, Celestino, Hong Thai, Vu, Chi Phuong, Mai, Thu Huong, Nguyen, Ngoc Ba, Nguyen, Xuan Khoa, Pham, Sarno, Euzenir N, Alter, Andrea, Montpetit, Alexandre, Moraes, Maria E, Moraes, José R, Doré, Carole, Gallant, Caroline J, Lepage, Pierre, Verner, Andrei, van de Vosse, Esther, Hudson, Thomas J

“…Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year. It has long been thought that leprosy has a strong genetic…”
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Evaluation of TRAF6 in a large multiancestral lupus cohort by Namjou, Bahram, Choi, Chan-Bum, Harley, Isaac T. W., Alarcón-Riquelme, Marta E., Kelly, Jennifer A., Glenn, Stuart B., Ojwang, Joshua O., Adler, Adam, Kim, Kwangwoo, Gallant, Caroline J., Boackle, Susan A., Criswell, Lindsey A., Kimberly, Robert P., Brown, Elizabeth E., Edberg, Jeffrey, Alarcón, Graciela S., Stevens, Anne M., Jacob, Chaim O., Gilkeson, Gary S., Kamen, Diane L., Tsao, Betty P., Anaya, Juan-Manuel, Kim, Eun-Mi, Park, So-Yeon, Sung, Yoon-Kyoung, Guthridge, Joel M., Merrill, Joan T., Petri, Michelle, Ramsey-Goldman, Rosalind, Vilá, Luis M., Niewold, Timothy B., Martin, Javier, Pons-Estel, Bernardo A., Vyse, Timothy J., Freedman, Barry I., Moser, Kathy L., Gaffney, Patrick M., Williams, Adrienne H., Comeau, Mary E., Reveille, John D., Kang, Changwon, James, Judith A., Scofield, R. Hal, Langefeld, Carl D., Kaufman, Kenneth M., Harley, John B., Bae, Sang-Cheol

“…Objective Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable…”
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Identification of IRFB, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study by LESSARD, Christopher J, ADRIANTO, Indra, ZIEGLER, Julie, COMEAU, Mary E, MARION, Miranda, WAKELAND, Benjamin E, CHAOYING LIANG, RAMOS, Paula S, GRUNDAHL, Kiely M, GALLANT, Caroline J, ALARCON-RIQUELME, Marta E, ALARCON, Graciela S, ICE, John A, ANAYA, Juan-Manuel, BAE, Sang-Cheol, BOACKLE, Susan A, BROWN, Elizabeth E, CHANG, Deh-Ming, CHO, Soo-Kyung, CRISWE, Lindsey A, EDBERG, Jeffrey C, FREEDMAN, Barry I, GILKESON, Gary S, WILEY, Graham B, JACOB, Chaim O, JAMES, Judith A, KAMEN, Diane L, KIMBERLY, Robert P, KIM, Jae-Hoon, MARTIN, Javier, MERRILL, Joan T, NIEWOLD, Timothy B, PARK, So-Yeon, PETRI, Michelle A, KELLY, Jennifer A, PONS-ESTEL, Bernardo A, RAMSEY-GOLDMAN, Rosalind, REVEILLE, John D, HAL SCOFIELD, R, YEONG WOOK SONG, STEVENS, Anne M, TSAO, Betty P, VILA, Luis M, VYSE, Timothy J, YU, Chack-Yung, GLENN, Stuart B, GUTHRIDGE, Joel M, KAUFMAN, Kenneth M, HARLEY, John B, WAKELAND, Edward K, LANGEFELD, Carl D, GAFFNEY, Patrick M, MONTGOMERY, Courtney G, MOSER, Kathy L, ADLER, Adam J, HE LI, RASMUSSEN, Astrid, WILLIAMS, Adrienne H

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Identification of a Systemic Lupus Erythematosus Susceptibility Locus at 11 p13 between PDHX and CD44 in a Multiethnic Study by LESSARD, Christopher J, ADRIANTO, Indra, BAE, Sang-Cheol, BOACKLE, Susan A, BROWN, Elizabeth E, CHANG, Deh-Ming, CRISWELL, Lindsey A, EDBERG, Jeffrey C, FREEDMAN, Barry I, GREGERSEN, Peter K, GILKESON, Gary S, JACOB, Chaim O, KELLY, Jennifer A, JAMES, Judith A, KAMEN, Diane L, KIMBERLY, Robert P, MARTIN, Javier, MERRILL, Joan T, NIEWOLD, Timothy B, PARK, So-Yeon, PETRI, Michelle A, PONS-ESTEL, Bernardo A, RAMSEY-GOLDMAN, Rosalind, KAUFMAN, Kenneth M, REVEILLE, John D, YEONG WOOK SONG, STEVENS, Anne M, TSAO, Betty P, VILA, Luis M, VYSE, Timothy J, YU, Chack-Yung, GUTHRIDGE, Joel M, BRUNER, Gail R, LANGEFELD, Carl D, GRUNDAHL, Kiely M, MONTGOMERY, Courtney, HARLEY, John B, SCOFIELD, R. Hal, GAFFNEY, Patrick M, MOSER, Kathy L, ADLER, Adam, WILLIAMS, Adrienne H, GALLANT, Caroline J, ALARCON-RIQUELME, Marta E, ANAYA, Juan-Manuel

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Functional and genetic dissection of anti -mycobacterial immunity by Gallant, Caroline J

“…Tuberculosis (TB) is a major global health problem with an estimated 2 billion people worldwide infected with M. tuberculosis, the causative agent of TB, and…”
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A 3′‐untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus by Löfgren, Sara E., Delgado‐Vega, Angelica M., Gallant, Caroline J., Sánchez, Elena, Frostegård, Johan, Truedsson, Lennart, de Ramón Garrido, Enrique, Sabio, José M., González‐Escribano, María F., Pons‐Estel, Bernardo A., D'Alfonso, Sandra, Witte, Torsten, Lauwerys, Bernard R., Endreffy, Emoke, Kovács, László, Vasconcelos, Carlos, Martins da Silva, Berta, Martín, Javier, Alarcón‐Riquelme, Marta E., Kozyrev, Sergey V.

“…Objective Costimulatory receptor CD226 plays an important role in T cell activation, differentiation, and cytotoxicity. This study was undertaken to…”
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