Search Results - "Gallaher, E J"

Genetic Determinants of Morphine Activity and Thermal Responses in 15 Inbred Mouse Strains by Belknap, J.K, Riggan, J, Cross, S, Young, E.R, Gallaher, E.J, Crabbe, J.C

“…Mice from 15 standard inbred strains were tested for sensitivity to two effects of acute morphine administration, open-field activity, and body temperature…”
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Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice by Gallaher, E J, Jones, G E, Belknap, J K, Crabbe, J C

“…Rapid tolerance to rotarod ataxia has previously been demonstrated in mice after sequential ethanol injections. Here we tested DBA/2J and C57BL/6J mice for…”
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Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci by Crabbe, J C, Phillips, T J, Gallaher, E J, Crawshaw, L I, Mitchell, S R

“…Sensitivity and tolerance to ethanol-induced ataxia and hypothermia are determined in part by genetic factors; some genes that affect one of these traits may…”
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Genetic Determinants of Sensitivity to Diazepam in Inbred Mice by Crabbe, John C, Gallaher, Edward J, Cross, Stephen J, Belknap, John K

“…Mice from 15 standard inbred strains were tested for sensitivity to several effects of acute diazepam (DZ). Strains differed in sensitivity to DZ-induced:…”
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Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans by Shangraw, R E, Winter, R, Hromco, J, Robinson, S T, Gallaher, E J

“…Marked lactic acidosis occurs during orthotopic liver transplantation (OLT), especially during the anhepatic phase. Current standard therapy is NaHCO3,…”
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Volatile Anesthetic Requirements Differ in Mice Selectively Bred for Sensitivity or Resistance to Diazepam: Implications for the Site of Anesthesia by McCrae, Anne F, Gallaher, Edward J, Winter, Peter M, Firestone, Leonard L

“…One approach to elucidating the general anesthetic target has used genetic selection procedures, wherein animals are bred for sensitivity or resistance to…”
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Dissociation of the effect of aminoglutethimide on corticosterone biosynthesis from ataxic and hypothermic effects in DBA and C57 mice by Roberts, A J, Gallaher, E J, Keith, L D

“…Adrenalectomy is frequently used to deplete adrenocortical hormones in physiological and receptor-binding studies in animals. However, this procedure is…”
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Mouse lines selected for genetic differences in diazepam sensitivity by GALLAHER, E. J, HOLLISTER, L. E, GIONET, S. E, CRABBE, J. C

“…Selective breeding techniques were used to alter allelic frequencies responsible for diazepam sensitivity and resistance. We used the rotarod test to determine…”
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Differential change in neuroactive steroid sensitivity during ethanol withdrawal by Finn, D A, Gallaher, E J, Crabbe, J C

“…The progesterone metabolite 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-P or allopregnanolone) is a potent positive modulator of gamma-aminobutyric…”
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Benzodiazepine dependence in mice after ingestion of drug-containing food pellets by Gallaher, E J, Henauer, S A, Jacques, C J, Hollister, L E

“…Diazepam was administered to Swiss-Webster mice for 53 days as a mixture of drug in laboratory chow, leading to consumption as high as 1000 mg/kg/day. Low…”
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Halothane's effects on GABA-gated chloride flux in mice selectively bred for sensitivity or resistance to diazepam by Quinlan, J J, Gallaher, E J, Firestone, L L

“…The DS (diazepam-sensitive) and DR (diazepam-resistant) lines of mice, selected on the basis of their ataxic response to diazepam, also diverge in the…”
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Halothane Sensitivity in Replicate Mouse Lines Selected for Diazepam Sensitivity or Resistance by Quinlan, Joseph J., Jin, Kun, Gallaher, Edward J., McCrae, Anne F., Firestone, Leonard L.

“…We have previously shown that mice selected for sensitivity to diazepam are also more sensitive to halothane, and that halothane augments the γ-aminobutyric…”
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Rapidly developing functional tolerance to ethanol is accompanied by increased erythrocyte cholesterol in mice by Parsons, L M, Gallaher, E J, Goldstein, D B

“…We investigated the time course for development of functional tolerance to the ataxic effects of ethanol in four genetically distinct mouse populations. Two…”
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Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex by Allan, A M, Gallaher, E J, Gionet, S E, Harris, R A

“…The gamma-aminobutyric acid (GABA) receptor-operated chloride channel complex was evaluated in mice selected for differential sensitivity to the ataxic effects…”
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Initial sensitivity and tolerance to ethanol in mice genetically selected for diazepam sensitivity by Gallaher, E J, Gionet, S E

“…The benzodiazepine (BZ) receptor is coupled with a GABA-receptor chloride-ionophore complex. The BZs augment the GABA-induced increase in chloride conductance,…”
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Long-lasting single-dose tolerance to neurologic deficits induced by diazepam by HENAUER, S. A, GALLAHER, E. J, HOLLISTER, L. E

“…Development of single-dose tolerance to diazepam-induced neurologic deficits was assessed in mice by means of a rotarod test. Diazepam suspended in corn oil…”
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Genetic differences in behavioral sensitivity to a neuroactive steroid by Finn, D A, Roberts, A J, Lotrich, F, Gallaher, E J

“…Recent work found that lower endogenous levels of the gamma-aminobutyric acid-agonist, neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one…”
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Automated remote temperature measurement in small animals using a telemetry/microcomputer interface by Gallaher, E J, Egner, D A, Swen, J W

“…Temperatures can be obtained from small animals by implanting commercially available radio-telemetry probes (Mini-Mitters), thereby avoiding handling-induced…”
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Locomotor responses to benzodiazepines, barbiturates and ethanol in diazepam-sensitive (DS) and -resistant (DR) mice by PHILLIPS, T. J, GALLAHER, E. J

“…Diazepam-sensitive (DS) and -resistant (DR) mice were selectively bred for increased and reduced sensitivity to the ataxic effects of diazepam (40 mg/kg)…”
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Ethanol induced temperature disturbances measured by automated radiotelemetry by Gallaher, E J, Egner, D A

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