Search Results - "Gallagher, William P."

Dithiocarbamates: Reagents for the Removal of Transition Metals from Organic Reaction Media by Gallagher, William P, Vo, Anh

“…Dithiocarbamates (DTCs) are ligands known to chelate with Cu and other transition metals to form insoluble complexes. Wastewater treatment protocols have…”
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The Development of a Scalable, Chemoselective Nitro Reduction by Gallagher, William P, Marlatt, Mark, Livingston, Robert, Kiau, Susanne, Muslehiddinoglu, Jale

“…We have demonstrated a scalable chemoselective reduction of a nitro functional group in the presence of an aryl imine using (NH4)2S/EtOH or hydrogenation…”
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Development of a Practical Synthesis of a Functionalized Pyrrolo[2,1-f][1,2,4]triazine Nucleus by Zheng, Bin, Conlon, David A, Corbett, R. Michael, Chau, Melissa, Hsieh, Dau-Ming, Yeboah, Agnes, Hsieh, Daniel, Müslehiddinoğlu, Jale, Gallagher, William P, Simon, Jeffrey N, Burt, Justin

“…Functionalized pyrrolotriazine 1b is a key heterocyclic building block in the synthesis of BMS-690514, a potent anticancer agent. Described herein are our…”
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Stille Reactions Catalytic in Tin:  A “Sn−F” Route for Intermolecular and Intramolecular Couplings by Gallagher, William P, Maleczka, Robert E

“…Polymethylhydrosiloxane (PMHS) made hypercoordinate by KF(aq) allows Me3SnH to be recycled during a Pd(0)-catalyzed hydrostannation/Stille cascade. Starting…”
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Radical Perfluoroalkylation of Arenes via Carbanion Intermediates by Hernandez, Lucas W, Gallagher, William P, Guerrero, Carlos A, Gonzalez-Bobes, Francisco, Coombs, John R

“…The use of sodium dithionite with perfluoroalkyl iodides under basic conditions facilitates the direct perfluoroalkylation of arenes with pendant benzylic…”
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Stille Couplings Catalytic in Tin:  The “Sn−O” Approach by Gallagher, William P, Terstiege, Ina, Maleczka, Robert E

“…A one-pot tandem Pd-catalyzed hydrostannylation/Stille coupling protocol for the stereoselective generation of vinyltins and their subsequent union, employing…”
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One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent by Shi, Qing, Greenwood, Nathaniel S, Meehan, Mariah C, Park, Hyunsoo, Galella, Michael, Sandhu, Bhupinder, Khandelwal, Purnima, Coombs, John R, Gallagher, William P, Guerrero, Carlos A, Hynes, John, Dhar, T. G. Murali, Gonzalez Bobes, Francisco, Marcoux, David

“…This communication highlights the use of chiral sulfinamides as nitrogen nucleophiles in intermolecular aza-Michael reactions. When chiral sulfinamides are…”
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Stille Couplings Catalytic in Tin:  Beyond Proof-of-Principle by Maleczka, Robert E, Gallagher, William P, Terstiege, Ina

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Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores by McDaniel, Jade, Farley, Christopher A, Ramirez, Antonio, Sandhu, Bhupinder, Sarjeant, Amy, Shi, Qing, Han, Arthur, Gallagher, William P, Hynes, John, Dhar, T. G. Murali, Gonzalez-Bobes, Francisco, Coombs, John R, Marcoux, David

“…The use of the unprecedented annulating reagents methyl N-(tert-butylsulfinyl)-4-chlorobutanimidate and methyl N-(tert-butylsulfinyl)-5-bromopentanimidate…”
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Development of a Scalable Synthetic Route to BMS-986251. Part 1: Synthesis of the Cyclohexane Dicarboxylate Fragment by Kuppusamy, Sankar, Gangu, Aravind S, Kalidindi, Srinivas, Ponnusamy, Muthukrishnan, Tendulkar, Shankar, Venu, Alla, Palani, Senthil, Nagappan, Vedhachalam, Vinodini, Arun, Mudryk, Boguslaw, Rupasinghe, Sanjeewa, Joe, Candice L, Coombs, John R, Gallagher, William P, Kopp, Nathaniel, Gonzalez-Bobes, Francisco, Eastgate, Martin D, Vaidyanathan, Rajappa

“…The cyclohexane dicarboxylate unit of BMS-986251 (1), a potent and efficacious RORγt inverse agonist, was synthesized starting from Hagemann’s ester in seven…”
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Development of a Scalable Synthetic Route to BMS-986251, Part 2: Synthesis of the Tricyclic Core and the API by Kalidindi, Srinivas, Gangu, Aravind S, Kuppusamy, Sankar, Sathasivam, Shunmugaraj, Shekarappa, Vijaykumar, Murugan, Saravanan, Bondigela, Sivasankar, Kandasamy, Moorthy, Ghanta, Kishore, Vinodini, Arun, Shrikant, Abhishek, Ramachandran, Ravikumar, Gallagher, William P, Kopp, Nathaniel, González-Bobes, Francisco, Eastgate, Martin D, Vaidyanathan, Rajappa

“…BMS-986251, a potent and efficacious RORγt inverse agonist, was synthesized starting from 6-iodotetralone using 13 chemical transformations with only eight…”
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A Claisen Approach to 4′-Ed4T by Gallagher, William P, Deshpande, Prashant P, Li, Jun, Katipally, Kishta, Sausker, Justin

“…An efficient, stereoselective synthesis of 4′-Ed4T is demonstrated. The synthesis is highlighted by a regioselective TMSOTf-mediated acetal opening, a Claisen…”
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Microwave-Assisted One-Pot Hydrostannylation/Stille Couplings by Maleczka, Robert E, Lavis, Jérôme M, Clark, Damon H, Gallagher, William P

“…In a fraction of the time required by conventional methods, microwave-accelerated one-pot hydrostannylation/Stille coupling allows 1-alkynes to be efficiently…”
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Preparation of the HIV Attachment Inhibitor BMS-663068. Part 7. Development of a Regioselective Ullmann–Goldberg–Buchwald Reaction by Gallagher, William P, Soumeillant, Maxime, Chen, Ke, Fox, Richard J, Hsiao, Yi, Mack, Brendan, Iyer, Vidya, Fan, Junying, Zhu, Jason, Beutner, Gregory, Silverman, Steven M, Fanfair, Dayne D, Glace, Andrew W, Freitag, Adam, Sweeney, Jason, Ji, Yining, Blackmond, Donna G, Eastgate, Martin D, Conlon, David A

“…The discovery, development, and optimization of an Ullmann–Goldberg–Buchwald coupling reaction is described. This complex process represents a key…”
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PMHS-Mediated Couplings of Alkynes or Benzothiazoles with Various Electrophiles:  Application to the Synthesis of (−)-Akolactone A by Gallagher, William P, Maleczka, Robert E

“…Polymethylhydrosiloxane (PMHS) in combination with CsF facilitates the cross-coupling of alkynes or benzothiazoles with an array of vinyl, styryl, and aryl…”
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PMHS-Mediated Couplings of Alkynes or Benzothiazoles with Various Electrophiles:  Application to the Synthesis of (−)-Akolactone A by Gallagher, William P, Maleczka, Robert E

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A Radical Addition Approach to a Heptafluoro­isopropyl Substituted Arene, Combined with a Highly Diastereoselective Annulation Reaction To Synthesize the Tricyclic Core of BMS-986251 by Gallagher, William P, Coombs, John R, Guerrero, Carlos A, Simmons, Eric M, González-Bobes, Francisco

“…We have devised an asymmetric route to the tricyclic core 10 of BMS-986251. The six-step synthesis utilizes readily available starting materials, involves the…”
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Selective opening of nucleoside derived acetals to form highly functionalized vinyl ethers by Gallagher, William P., Beutner, Gregory L., Wadzinski, Tyler J., Deshpande, Prashant P.

“…[Display omitted] •Ring opening of cyclic acetal on a protected nucleoside gives high selectivity for a C2 vinyl ether.•High yield and selectivity can be…”
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Application of Fluoride-Catalyzed Silane Reductions of Tin Halides to the in Situ Preparation of Vinylstannanes by Maleczka, Robert E, Terrell, Lamont R, Clark, Damon H, Whitehead, Susan L, Gallagher, William P, Terstiege, Ina

“…We have found that either Bu3SnCl/PMHS/KF(aq) or the combination of tributyltin fluoride, PMHS, and catalytic quantities of tetrabutylammonium fluoride can…”
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A Radical Addition Approach to a Heptafluoroisopropyl Substituted Arene, Combined with a Highly Diastereoselective Annulation Reaction To Synthesize the Tricyclic Core of BMS-986251 by Gallagher, William P., Coombs, John R., Guerrero, Carlos A., Simmons, Eric M., González-Bobes, Francisco

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