Search Results - "Gallagher, Kim P"

Spontaneous thrombosis in mice carrying the factor V Leiden mutation by Cui, Jisong, Eitzman, Daniel T., Westrick, Randal J., Christie, Patricia D., Xu, Zuojun J., Yang, Angela Y., Purkayastha, Anjali A., Yang, Tony L., Metz, Alan L., Gallagher, Kim P., Tyson, Julia A., Rosenberg, Robert D., Ginsburg, David

“…A polymorphism in coagulation factor V, factor V Leiden (FVL), is the major known genetic risk factor for thrombosis in humans. Approximately 10% of mutation…”
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Spontaneous thrombosis in mice carrying the factor V Leiden mutation by Cui, Jisong, Eitzman, Daniel T., Westrick, Randal J., Christie, Patricia D., Xu, Zuojun J., Yang, Angela Y., Purkayastha, Anjali A., Yang, Tony L., Metz, Alan L., Gallagher, Kim P., Tyson, Julia A., Rosenberg, Robert D., Ginsburg, David

“…A polymorphism in coagulation factor V, factor V Leiden (FVL), is the major known genetic risk factor for thrombosis in humans. Approximately 10% of mutation…”
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Concomitant endothelin receptor subtype-A blockade during the progression of pacing-induced congestive heart failure in rabbits: Beneficial effects on left ventricular and myocyte function by SPINALE, F. G, WALKER, J. D, MUKHERJEE, R, IANNINI, J. P, KEEVER, A. T, GALLAGHER, K. P

“…Plasma levels of endothelin-1 (ET-1) are increased in patients and animals with severe congestive heart failure (CHF). It remains unknown, however, whether…”
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Spatial and temporal characteristics of circumferential flow-function relations during acute myocardial ischemia in the conscious dog by Buda, A J, Shlafer, M, Gallagher, K P

“…In the anesthetized open-chest dog the ischemic area produced by coronary occlusion is surrounded by an area of nonischemic contractile dysfunction, identified…”
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Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation by Simpson, P J, Mitsos, S E, Ventura, A, Gallagher, K P, Fantone, J C, Abrams, G D, Schork, M A, Lucchesi, B R

“…Prostacyclin (PGI2) and the stable PGI2 analogue SC39902 (6,9 alpha-epoxy,5S-fluoro-11 alpha, 15S-dehydroxyprosta-6,13E-dien-1-oic acid, sodium salt) were…”
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Effects of endothelin ET A receptor antagonism with PD 156707 on hemodynamics and renal vascular resistance in rabbits by Ignasiak, Diane P, McClanahan, Thomas B, Saganek, Lori J, Potoczak, Ronald E, Hallak, Hussein, Gallagher, Kim P

“…The objective of this study was to determine the in vivo effectiveness of the selective endothelin ET A receptor antagonist PD 156707 {sodium…”
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The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis by MCCLANAHAN, Thomas B, HICKS, Gary W, IGNASIAK, Diane P, BOUSLEY, Richard, MERTZ, Thomas E, JUNEAU, Paul, JANICZEK-DOLPHIN, Nancy, KIM, In-Chull, GALLAGHER, Kim P

“…Direct thrombin inhibitors represent a new class of drug that may offer a therapeutic alternative for the treatment and prevention of thrombembolic conditions,…”
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Antithrombotic effect of LB-30057 (CI-1028), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: Comparison with inogatran by LIGUO CHI, MERTZ, Thomas E, ROGERS, Karen L, JANICZEK, Nancy, PENG, Yun-Wen, SAGANEK, Lori, BOUSLEY, Richard F, JUNEAU, Paul L, UPRICHARD, Andrew C. G, GALLAGHER, Kim P

“…LB-30057 (CI-1028) is a novel, orally bioavailable, direct thrombin inhibitor with a Ki of 0.38 nM against human thrombin. The effects of LB-30057 on thrombus…”
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A novel model of venous thrombosis in the vena cava of rabbits by Chi, Liguo, Saganek, Lori J, Rogers, Karen L, Mertz, Thomas E, Metz, Alan L, Uprichard, Andrew C.G, Gallagher, Kim P

“…The objective of this study was to develop and validate a new experimental model of venous thrombosis in the rabbit. A 3-cm length of siliconized PE tubing was…”
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Myocardial contractility in a canine model of the brain-dead organ donor by Huber, T S, Groh, M A, Gallagher, K P, D'Alecy, L G

“…To test the hypothesis that the induction and maintenance of brain death leads to a decrease in myocardial contractility. Prospective, randomized, controlled…”
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Effects of nontransmural ischemia on inner and outer wall thickening in the canine left ventricle by Torry, R J, Myers, J H, Adler, A L, Liut, C L, Gallagher, K P

“…The effect of ischemic subendocardial dysfunction on contractile function in the normally perfused subepicardium remains controversial. Accordingly, regional…”
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Effects of Endothelin-Receptor Antagonism with PD156707 on Myocardial Stunning in Swine by McClanahan, Thomas B, Mertz, Thomas E, Ignasiak, Diane P, Juneau, Paul L, Gallagher, Kim P

“…SUMMARYEndothelin (ET) has been proposed to play a role in the pathogenesis of myocardial ischemia/reperfusion injury. The potential role of ET in myocardial…”
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The regional effect of retrograde cardioplegia in areas of evolving ischemia by Iannettoni, M D, Rohs, Jr, T J, Gallagher, K P, Bolling, S F

“…Retrograde cardioplegia (RCP) is often used for myocardial protection during coronary bypass grafting, but the regional effect of RCP in areas of evolving…”
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Xanthine oxidase inhibition attenuates ischemic-reperfusion lung injury by Lynch, M J, Grum, C M, Gallagher, K P, Bolling, S F, Deeb, G M, Morganroth, M L

“…Ischemic-reperfusion lung injury is a factor potentially limiting the usefulness of distant organ procurement for heart-lung transplantation. Toxic oxygen…”
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Hemodynamic effects of intraatrial administration of deferoxamine or deferoxamine-pentafraction conjugate to conscious dogs by Forder, J R, McClanahan, T B, Gallagher, K P, Hedlund, B E, Hallaway, P E, Shlafer, M

“…Deferoxamine (DFX) is a specific Fe3+ chelator that is used to manage iron overload, and is being evaluated as an agent to reduce ischemic organ damage that…”
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Subepicardial vasodilator reserve in the presence of critical coronary stenosis in dogs by Gallagher, Kim P., Folts, John D., Shebuski, Ronald J., Rankin, John H.G., Rowe, George G.

“…Critical coronary stenosis is the term used to describe obstruction that eliminates reactive hyperemia presumably because downstream arterioles have dilated…”
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A reversible pulmonary artery band: Preliminary experience by Rocchini, Albert P, Gundry, Steven R, Beekman, Robert H, Gallagher, Kim P, Heidelberger, Kathleen, Bove, Edward, Behrendt, Douglas M, Dysko, Robert C, Rosen, Karen

“…Pulmonary artery banding has become an infrequently used surgical technique. However, if a band was developed that could be relieved without the need for open…”
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Myocardial protection with preconditioning by LI, G. C, VASQUEZ, J. A, GALLAGHER, K. P, LUCCHESI, B. R

“…Myocardial preconditioning with brief coronary artery occlusions before a sustained ischemic period is reported to reduce infarct size. To determine the number…”
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Reduction of exercise-induced ischemic regional myocardial dysfunction by verapamil in conscious dogs by Osakada, G, Kumada, T, Gallagher, K P, Kemper, W S, Ross, Jr, J

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Pretreatment with Endothelin-1 Mimics Ischemic Preconditioning Against Infarction in Isolated Rabbit Heart by Wang, Peipei, Gallagher, Kim P., Downey, James M., Cohen, Michael V.

“…We have proposed that ischemic preconditioning in rabbit hearts is initiated by adenosine receptor stimulation resulting in activation of protein kinase C. If…”
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