Search Results - "Gallagher, Elyssia S"

Molecular Dynamics Simulations of Native Protein Charging via Proton Transfer during Electrospray Ionization with Grotthuss Diffuse H3O by Cordes, Michael S., Gallagher, Elyssia S.

“…Unraveling the mechanism by which native proteins are charged through electrospray ionization (ESI) has been the focus of considerable research because…”
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Molecular Dynamics Simulations of Native Protein Charging via Proton Transfer during Electrospray Ionization with Grotthuss Diffuse H 3 O by Cordes, Michael S, Gallagher, Elyssia S

“…Unraveling the mechanism by which native proteins are charged through electrospray ionization (ESI) has been the focus of considerable research because…”
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Metal adduction in mass spectrometric analyses of carbohydrates and glycoconjugates by Gass, Darren T., Quintero, Ana V., Hatvany, Jacob B., Gallagher, Elyssia S.

“…Glycans, carbohydrates, and glycoconjugates are involved in many crucial biological processes, such as disease development, immune responses, and cell–cell…”
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Hydrogen/deuterium exchange for the analysis of carbohydrates by Hatvany, Jacob B., Gallagher, Elyssia S.

“…Carbohydrates and glycans are integral to many biological processes, including cell-cell recognition and energy storage. However, carbohydrates are often…”
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Mapping Protein-Ligand Interactions with Proteolytic Fragmentation, Hydrogen/Deuterium Exchange-Mass Spectrometry by Gallagher, Elyssia S, Hudgens, Jeffrey W

“…Biological processes are the result of noncovalent, protein-ligand interactions, where the ligands range from small organic and inorganic molecules to lipids,…”
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Characterizing Theta-Emitter Generation for Use in Microdroplet Reactions by Hatvany, Jacob B, Olsen, Emma-Le P, Gallagher, Elyssia S

“…Theta emitters are useful for generating microdroplets for rapid-mixing reactions. Theta emitters are glass tips containing an internal septum that separates…”
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Effect of pH on In-Electrospray Hydrogen/Deuterium Exchange of Carbohydrates and Peptides by Hatvany, Jacob B., Liyanage, O. Tara, Gallagher, Elyssia S.

“…Carbohydrates are critical for cellular functions as well as an important class of metabolites. Characterizing carbohydrate structures is a difficult…”
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Characterizing the Dynamics of Solvated Disaccharides with In-Electrospray Ionization Hydrogen/Deuterium Exchange-Mass Spectrometry by Quintero, Ana V., Liyanage, O. Tara, Kim, H. Jamie, Gallagher, Elyssia S.

“…Carbohydrates have various biological functions that are based on their structures. However, the composition and the glycosidic-bond linkage and configuration…”
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Achieving multiple hydrogen/deuterium exchange timepoints of carbohydrate hydroxyls using theta-electrospray emitters by Kim, H Jamie, Gallagher, Elyssia S

“…Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) is a well-established technique for structural analysis of proteins. In HDX experiments it is…”
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Propagating Error through Traveling-Wave Ion Mobility Calibration by Edwards, Alexis N, Tran, Hien M, Gallagher, Elyssia S

“…Native mass spectrometry (MS) is used to elucidate the stoichiometry of protein complexes and quantify binding interactions by maintaining native-like,…”
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Automated Removal of Phospholipids from Membrane Proteins for H/D Exchange Mass Spectrometry Workflows by Anderson, Kyle W, Gallagher, Elyssia S, Hudgens, Jeffrey W

“…Membrane proteins are currently the most common targets for pharmaceuticals. However, characterization of their structural dynamics by hydrogen/deuterium…”
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Evidence of H/D Exchange within Metal-Adducted Carbohydrates after Ion/Ion-Dissociation Reactions by Gass, Darren T., Cordes, Michael S., Alberti, Sebastian N., Kim, H. Jamie, Gallagher, Elyssia S.

“…Tandem mass spectrometry (MS/MS) using fragmentation has become one of the most effective methods for gaining sequence and structural information on…”
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Formation of Carbohydrate–Metal Adducts from Solvent Mixtures during Electrospray: A Molecular Dynamics and ESI-MS Study by Calixte, Emvia I, Liyanage, O. Tara, Gass, Darren T, Gallagher, Elyssia S

“…Electrospray ionization (ESI) is frequently used to produce gas-phase ions for mass spectrometry (MS)-based techniques. The composition of solvents used in…”
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Distinguishing Carbohydrate Isomers with Rapid Hydrogen/Deuterium Exchange-Mass Spectrometry by Liyanage, O Tara, Quintero, Ana V, Hatvany, Jacob B, Gallagher, Elyssia S

“…Carbohydrates play key roles in facilitating cellular functions, yet characterizing their structures is analytically challenging due to the presence of…”
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Gas-phase stability and thermodynamics of ligand-bound, binary complexes of chloramphenicol acetyltransferase reveal negative cooperativity by Edwards, Alexis N., Blue, Anthony J., Conforti, Jessica M., Cordes, Michael S., Trakselis, Michael A., Gallagher, Elyssia S.

“…The biological role of the bacterial chloramphenicol (Chl)–resistance enzyme, chloramphenicol acetyltransferase (CAT), has seen renewed interest due to the…”
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Release of Carbohydrate–Metal Adducts from Electrospray Droplets: Insight into Glycan Ionization by Electrospray by Calixte, Emvia I, Liyanage, O. Tara, Kim, H. Jamie, Ziperman, Emily D, Pearson, Amanda J, Gallagher, Elyssia S

“…Glycans have an immense number of biological activities, necessitating increased efforts to characterize glycan structures. Mass spectrometry has been coupled…”
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HDX-MS and MD Simulations Provide Evidence for Stabilization of the IgG1—FcγRIa (CD64a) Immune Complex Through Intermolecular Glycoprotein Bonds by Anderson, Kyle W., Bergonzo, Christina, Scott, Kerry, Karageorgos, Ioannis L., Gallagher, Elyssia S., Tayi, Venkata S., Butler, Michael, Hudgens, Jeffrey W.

“…[Display omitted] •Previous studies present discordant models of Fc—FcγRI complex stabilization.•HDX-MS of IgG1—FcγRI complexes infers presence of…”
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Overview of Characterizing Cancer Glycans with Lectin-Based Analytical Methods by Pearson, Amanda J, Gallagher, Elyssia S

“…Glycosylation is a post-translational modification that is often altered in disease development and progression, including cancer. In cancerous patients, the…”
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Differences in Protein Capture by SP3 and SP4 Demonstrate Mechanistic Insights of Proteomics Cleanup Techniques by Conforti, Jessica M., Ziegler, Amanda M., Worth, Charli S., Nambiar, Adhwaitha M., Bailey, Jacob T., Taube, Joseph H., Gallagher, Elyssia S.

“…The goal of proteomics experiments is to identify proteins to observe changes in cellular processes and diseases. One challenge in proteomics is the removal of…”
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Mass Spectral Detection of Forward- and Reverse-Hydrogen/Deuterium Exchange Resulting from Residual Solvent Vapors in Electrospray Sources by Kim, H. Jamie, Liyanage, O. Tara, Mulenos, Marina R., Gallagher, Elyssia S.

“…Characterizing glycans is analytically challenging since glycans are heterogeneous, branched polymers with different three-dimensional conformations…”
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