Search Results - "Galla, Luisa"
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Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2
Published in International journal of molecular sciences (24-01-2020)“…Alzheimer's disease (AD) is the most common form of dementia. Even though most AD cases are sporadic, a small percentage is familial due to autosomal dominant…”
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Generation and Characterization of a New FRET-Based Ca2+ Sensor Targeted to the Nucleus
Published in International journal of molecular sciences (14-09-2021)“…Calcium (Ca2+) exerts a pivotal role in controlling both physiological and detrimental cellular processes. This versatility is due to the existence of a…”
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A cohort analysis of SARS-CoV-2 anti-spike protein receptor binding domain (RBD) IgG levels and neutralizing antibodies in fully vaccinated healthcare workers
Published in Clinical chemistry and laboratory medicine (27-06-2022)“…The waning of humoral immunity after COVID-19 vaccine booster (third dose) has not yet been fully evaluated. This study updates data on anti-SARS-CoV-2 spike…”
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Altered Cl⁻ homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability
Published in Proceedings of the National Academy of Sciences - PNAS (12-01-2021)“…Impairments of inhibitory circuits are at the basis of most, if not all, cognitive deficits. The impact of OPHN1, a gene associate with intellectual disability…”
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Familial Alzheimer’s disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability
Published in Aging clinical and experimental research (01-06-2021)“…Alzheimer’s disease (AD) is the most frequent cause of dementia in the elderly. Few cases are familial (FAD), due to autosomal dominant mutations in…”
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Circadian Control of Fatty Acid Elongation by SIRT1 Protein-mediated Deacetylation of Acetyl-coenzyme A Synthetase 1
Published in The Journal of biological chemistry (28-02-2014)“…The circadian clock regulates a wide range of physiological and metabolic processes, and its disruption leads to metabolic disorders such as diabetes and…”
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Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease
Published in Cells (Basel, Switzerland) (21-01-2021)“…Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder in which learning, memory and cognitive functions decline progressively…”
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Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL
Published in PloS one (21-10-2010)“…In spite of leukemia therapy improvements obtained over the last decades, therapy is not yet effective in all cases. Current approaches in Acute Lymphoblastic…”
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mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca2+ Dynamics In Vivo
Published in iScience (28-06-2019)“…Genetically Encoded Ca 2+ Indicators (GECIs) are extensively used to study organelle Ca 2+ homeostasis, although some available probes are still plagued by a…”
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Two rapid SARS-CoV-2 disposable devices for semi-quantitative S-RBD antibody levels determination compared with CLIA and ELISA assays at different protective thresholds
Published in Clinica chimica acta (01-04-2022)“…•Timely, cost-effective determination of SARS-CoV-2 Ab could help pandemic migration.•iRapid self-test and professional measure neutralizing Ab in a…”
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SARS-CoV-2 specific T-cell humoral response assessment after COVID-19 vaccination using a rapid direct real-time PCR amplification
Published in Clinical chemistry and laboratory medicine (28-08-2023)“…The SARS-CoV-2 immune response is mediated by both humoral and cellular immunity. In this study, SARS-CoV-2 specific cellular immunity was tested by a novel…”
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Seroprevalence of SARS-CoV-2 antibodies in Italy in newborn dried blood spots
Published in Clinical chemistry and laboratory medicine (27-01-2023)“…Serosurveys can be used to monitor COVID-19 seroprevalence and conduct surveillance. Dried blood spot (DBS), used increasingly as a valuable sample to assay…”
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13
Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb
Published in Human molecular genetics (01-12-2016)“…Among the X-linked genes associated with intellectual disability, Oligophrenin-1 (OPHN1) encodes for a Rho GTPase-activating protein, a key regulator of…”
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Low PKCα expression within the MRD-HR stratum defines a new subgroup of childhood T-ALL with very poor outcome
Published in Oncotarget (30-07-2014)“…Pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL) outcome has improved in the last decades, yet one patient in every four still relapses. Except treatment…”
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Lack of Protein Kinase C Alpha Is Associated with Poor Prognosis in Pediatric T-Lineage Acute Lymphoblastic Leukemia
Published in Blood (18-11-2011)“…Abstract 744 T-lineage Acute Lymphoblastic Leukemia (T-ALL) accounts for about 15% of pediatric ALL. Although the outcome of T-ALL has improved with current…”
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mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca2+ Dynamics In Vivo
Published in iScience (27-09-2019)Get full text
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mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca 2+ Dynamics In Vivo
Published in iScience (30-07-2019)Get full text
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mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca 2+ Dynamics In Vivo
Published in iScience (27-05-2019)“…Genetically Encoded Ca Indicators (GECIs) are extensively used to study organelle Ca homeostasis, although some available probes are still plagued by a number…”
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High Risk Acute Lymphoblastic Leukemia with Rapid NOD/SCID Engraftment Is Characterized by High Protein Expression of CYCLIN B, Beta-CATENIN, ANNEXIN I and Decreased PKC Alpha Activation
Published in Blood (18-11-2011)“…Abstract 1457 Acute lymphoblastic leukemia (ALL) is the most frequent form of childhood cancer. Although therapy efforts have achieved cure rates of above 80%,…”
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Activation of Non-Canonical Wnt Pathway in Human Mesenchymal Cells Affects Osteogenic Differentiation: A Potential Target in Multiple Myeloma Microenvironment
Published in Blood (16-11-2008)“…Osteoblast suppression is the hallmark of Multiple Myeloma (MM) osteolytic bone lesions mainly due to the capacity of MM cells to inhibit the osteogenic…”
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