Search Results - "Galla, Fabian"

Comparison of in Silico, Electrochemical, in Vitro and in Vivo Metabolism of a Homologous Series of (Radio)fluorinated σ1 Receptor Ligands Designed for Positron Emission Tomography by Wiese, Christian, Große Maestrup, Eva, Galla, Fabian, Schepmann, Dirk, Hiller, Achim, Fischer, Steffen, Ludwig, Friedrich-Alexander, Deuther-Conrad, Winnie, Donat, Cornelius K., Brust, Peter, Büter, Lars, Karst, Uwe, Wünsch, Bernhard

“…The imaging of σ1 receptors in the brain by fluorinated radiotracers will be used for the validation of σ1 receptors as drug targets as well as for…”
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Pharmacokinetic properties of enantiomerically pure GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold by Börgel, Frederik, Galla, Fabian, Lehmkuhl, Kirstin, Schepmann, Dirk, Ametamey, Simon M., Wünsch, Bernhard

“…[Display omitted] •Pharmacokinetic properties of three pairs of enantiomers were analyzed.•High performance affinity chromatography led to human serum albumin…”
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Design, (Radio)Synthesis, and in Vitro and in Vivo Evaluation of Highly Selective and Potent Matrix Metalloproteinase 12 (MMP-12) Inhibitors as Radiotracers for Positron Emission Tomography by Butsch, Viktoria, Börgel, Frederik, Galla, Fabian, Schwegmann, Katrin, Hermann, Sven, Schäfers, Michael, Riemann, Burkhard, Wünsch, Bernhard, Wagner, Stefan

“…Dysregulated levels of activated matrix metalloproteinases (MMPs) are linked to different pathologies, such as cancer, atherosclerosis, neuroinflammation, and…”
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Phenylethylene glycol-derived LpxC inhibitors with diverse Zn2+-binding groups by Galster, Magdalena, Löppenberg, Marius, Galla, Fabian, Börgel, Frederik, Agoglitta, Oriana, Kirchmair, Johannes, Holl, Ralph

“…The Zn2+-dependent bacterial deacetylase LpxC is a promising target for the development of novel antibiotics. Most of the known LpxC inhibitors carry a…”
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Synthesis and Pharmacological Evaluation of 5‑Pyrrolidinylquinoxalines as a Novel Class of Peripherally Restricted κ‑Opioid Receptor Agonists by Bourgeois, Christian, Werfel, Elena, Galla, Fabian, Lehmkuhl, Kirstin, Torres-Gómez, Héctor, Schepmann, Dirk, Kögel, Babette, Christoph, Thomas, Straßburger, Wolfgang, Englberger, Werner, Soeberdt, Michael, Hüwel, Sabine, Galla, Hans-Joachim, Wünsch, Bernhard

“…5-Pyrrolidinyl substituted perhydroquinoxalines were designed as conformationally restricted κ-opioid receptor agonists restricted to the periphery. The…”
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Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability by Hugenberg, Verena, Hermann, Sven, Galla, Fabian, Schäfers, Michael, Wünsch, Bernhard, Kolb, Hartmuth C, Szardenings, Katrin, Lebedev, Artem, Walsh, Joseph C, Mocharla, Vani P, Gangadharmath, Umesh B, Kopka, Klaus, Wagner, Stefan

“…Abstract Introduction Dysregulated MMP expression or activation is associated with several diseases. To study MMP activity in vivo by means of PET a…”
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Comparison of inSilico, Electrochemical, inVitro and inVivo Metabolism of a Homologous Series of (Radio)fluorinated [sigma]1 Receptor Ligands Designed for Positron Emission Tomography by Wiese, Christian, GrosseMaestrup, Eva, Galla, Fabian, Schepmann, Dirk, Hiller, Achim, Fischer, Steffen, Ludwig, Friedrich-Alexander, Deuther-Conrad, Winnie, Donat, Cornelius K, Brust, Peter, Buter, Lars, Karst, Uwe, Wunsch, Bernhard

“…The imaging of σ1 receptors in the brain by fluorinated radiotracers will be used for the validation of σ1 receptors as drug targets as well as for…”
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Comparison of inSilico, Electrochemical, inVitro and inVivo Metabolism of a Homologous Series of (Radio)fluorinated sigma sub(1) Receptor Ligands Designed for Positron Emission Tomography by Wiese, Christian, GroseMaestrup, Eva, Galla, Fabian, Schepmann, Dirk, Hiller, Achim, Fischer, Steffen, Ludwig, Friedrich-Alexander, Deuther-Conrad, Winnie, Donat, Cornelius K, Brust, Peter, Bueter, Lars, Karst, Uwe, Wuensch, Bernhard

“…The imaging of sigma sub(1) receptors in the brain by fluorinated radiotracers will be used for the validation of sigma sub(1) receptors as drug targets as…”
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Comparison of in Silico, Electrochemical, in Vitro and in Vivo Metabolism of a Homologous Series of (Radio)fluorinated σ 1 Receptor Ligands Designed for Positron Emission Tomography by Wiese, Christian, Große Maestrup, Eva, Galla, Fabian, Schepmann, Dirk, Hiller, Achim, Fischer, Steffen, Ludwig, Friedrich-Alexander, Deuther-Conrad, Winnie, Donat, Cornelius K, Brust, Peter, Büter, Lars, Karst, Uwe, Wünsch, Bernhard

“…The imaging of σ receptors in the brain by fluorinated radiotracers will be used for the validation of σ receptors as drug targets as well as for differential…”
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Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB2 Ligands with Increased Polarity by Lueg, Corinna, Galla, Fabian, Frehland, Bastian, Schepmann, Dirk, Daniliuc, Constantin G., Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard

“…In order to increase the polarity of the potent CB2 ligand 1a, the homologous hydroxyalkyl carbazoles 2a–c were prepared and pharmacologically evaluated. An…”
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Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB 2 Ligands with Increased Polarity by Lueg, Corinna, Galla, Fabian, Frehland, Bastian, Schepmann, Dirk, Daniliuc, Constantin G., Deuther‐Conrad, Winnie, Brust, Peter, Wünsch, Bernhard

“…In order to increase the polarity of the potent CB 2 ligand 1a , the homologous hydroxyalkyl carbazoles 2a – c were prepared and pharmacologically evaluated…”
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Hydroxyalkylation with cyclic sulfates: synthesis of carbazole derived CB(2) ligands with increased polarity by Lueg, Corinna, Galla, Fabian, Frehland, Bastian, Schepmann, Dirk, Daniliuc, Constantin G, Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard

“…In order to increase the polarity of the potent CB2 ligand 1a, the homologous hydroxyalkyl carbazoles 2a-c were prepared and pharmacologically evaluated. An…”
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