Search Results - "Galkin, Ilia"

Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes by Zaitsev, Aleksandr, Chelushkin, Maksim, Dyikanov, Daniiar, Cheremushkin, Ilya, Shpak, Boris, Nomie, Krystle, Zyrin, Vladimir, Nuzhdina, Ekaterina, Lozinsky, Yaroslav, Zotova, Anastasia, Degryse, Sandrine, Kotlov, Nikita, Baisangurov, Artur, Shatsky, Vladimir, Afenteva, Daria, Kuznetsov, Alexander, Paul, Susan Raju, Davies, Diane L., Reeves, Patrick M., Lanuti, Michael, Goldberg, Michael F., Tazearslan, Cagdas, Chasse, Madison, Wang, Iris, Abdou, Mary, Aslanian, Sharon M., Andrewes, Samuel, Hsieh, James J., Ramachandran, Akshaya, Lyu, Yang, Galkin, Ilia, Svekolkin, Viktor, Cerchietti, Leandro, Poznansky, Mark C., Ataullakhanov, Ravshan, Fowler, Nathan, Bagaev, Alexander

“…Cellular deconvolution algorithms virtually reconstruct tissue composition by analyzing the gene expression of complex tissues. We present the decision tree…”
Get full text

Lack of intrafollicular memory CD4 + T cells is predictive of early clinical failure in newly diagnosed follicular lymphoma by Mondello, Patrizia, Fama, Angelo, Larson, Melissa C., Feldman, Andrew L., Villasboas, Jose C., Yang, Zhi-Zhang, Galkin, Ilia, Svelolkin, Viktor, Postovalova, Ekaterina, Bagaev, Alexander, Ovcharov, Pavel, Varlamova, Arina, Huet, Sarah, Tesson, Bruno, McGrath, Kaitlyn R., Slager, Susan, Link, Brian K., Syrbu, Sergei, Novak, Anne J., Habermann, Thomas M., Witzig, Thomas E., Nowakowski, Grzegorz S., Salles, Gilles, Cerhan, James R., Ansell, Stephen M.

“…Despite a characteristic indolent course, a substantial subset of follicular lymphoma (FL) patients has an early relapse with a poor outcome. Cells in the…”
Get full text

Spatial mapping of human hematopoiesis at single-cell resolution reveals aging-associated topographic remodeling by Sarachakov, Aleksandr, Varlamova, Arina, Svekolkin, Viktor, Polyakova, Margarita, Valencia, Itzel, Unkenholz, Caitlin, Pannellini, Tania, Galkin, Ilia, Ovcharov, Pavel, Tabakov, Dmitrii, Postovalova, Ekaterina, Shin, Nara, Sethi, Isha, Bagaev, Alexander, Itkin, Tomer, Crane, Genevieve, Kluk, Michael, Geyer, Julia, Inghirami, Giorgio, Patel, Sanjay

“…The spatial anatomy of hematopoiesis in the bone marrow (BM) has been extensively studied in mice and other preclinical models, but technical challenges have…”
Get full text

A clinical AI-driven multiplex immunofluorescence imaging pipeline to characterize tumor microenvironment heterogeneity by Zarubin, Dmitry, Belotskiy, Valeriy, Xiang, Zhongmin, Varlamova, Arina, Ovcharov, Pavel, Galkin, Ilia, Polyakova, Margarita, Svekolkin, Viktor, Perelman, Grigory, Bruttan, Maria, Brown, Jessica H., Postovalova, Ekaterina, Bagaev, Aleksander, Fowler, Nathan

“…3020 Background: Understanding the underlying heterogeneity of the tumor microenvironment (TME) on a single-cell level is becoming increasingly important to…”
Get full text

A digital imaging analysis (DIA) platform for identifying tertiary lymphoid structures (TLS) in lung adenocarcinoma (LUAD) by Kushnarev, Vladimir, Belozerova, Anna, Dymov, Daniil, Popov, Yuriy, Lukashevich, Nadezhda, Valiev, Ivan, Shamsutdinova, Diana, Akaeva, Aida, Galkin, Ilia, Popyvanov, Lev, Svekolkin, Viktor, Nomie, Krystle, Love, Anna, Bagaev, Alexander, Postovalova, Ekaterina, Fowler, Nathan

“…3142 Background: Previous studies of non-small cell lung cancer (NSCLC) have shown that TLS can be predictive of therapy response and a positive prognostic…”
Get full text

Single-cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer by Pachynski, Russell K, Kim, Eric H, Miheecheva, Natalia, Kotlov, Nikita, Ramachandran, Akshaya, Postovalova, Ekaterina, Galkin, Ilia, Svekolkin, Viktor, Lyu, Yang, Zou, Qiong, Cao, Dengfeng, Gaut, Joseph, Ippolito, Joseph E, Bagaev, Alexander, Bruttan, Maria, Gancharova, Olga, Nomie, Krystle, Tsiper, Maria, Andriole, Gerald L, Ataullakhanov, Ravshan, Hsieh, James J

“…Multiparametric MRI (mpMRI) has become an indispensable radiographic tool in diagnosing prostate cancer. However, mpMRI fails to visualize approximately 15% of…”
Get full text

Topographic Analysis of Low-Grade Myeloid Neoplasms By Multiparametric in Situ Imaging of Human Bone Marrow Core Biopsy Tissues by Patel, Sanjay, Svekolkin, Viktor, Varlamova, Arina, Galkin, Ilia, Valencia, Itzel, Akaeva, Aida, Smirnova, Sofia, Ovcharov, Pavel, Polyakova, Margarita, Tabakov, Dmitrii, Postovalova, Ekaterina, Koltakova, Eleonora, Gunn, Sarah, Bagaev, Alexander, Geyer, Julia T

“…Diagnosis of low-grade myelodysplastic syndromes (LG-MDS) is one of the most challenging in hematopathology as it relies predominantly on morphologic…”
Get full text

Abstract 2742: Integrated multiregional transcriptomic and multi-parameter single-cell imaging analysis of clear cell renal cell carcinoma elucidates diverse cellular communities present within the tumor microenvironment by Miheecheva, Natalia, Ramachandran, Akshaya, Lyu, Yang, Postovalova, Ekaterina, Svekolkin, Viktor, Galkin, Ilia, Ovcharov, Pavel, Shamsutdinova, Diana, Zyrin, Vladimir, Bagaev, Alexander, Nomie, Krystle, Frenkel, Felix, Ataullakhanov, Ravshan, Hsieh, James J.

“…Abstract Although genomic analyses of clear cell renal cell carcinoma (ccRCC) patients have revealed targetable pathways that have led to FDA-approved…”
Get full text

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients by Radtke, Andrea J, Postovalova, Ekaterina, Varlamova, Arina, Bagaev, Alexander, Sorokina, Maria, Kudryashova, Olga, Meerson, Mark, Polyakova, Margarita, Galkin, Ilia, Svekolkin, Viktor, Isaev, Sergey, Wiebe, Daniil, Sharun, Anna, Sarachakov, Alexander, Perelman, Grigory, Lozinsky, Yaroslav, Yaniv, Ziv, Lowekamp, Bradley C, Speranza, Emily, Yao, Li, Pittaluga, Stefania, Shaffer, 3rd, Arthur L, Jonigk, Danny, Phelan, James D, Davies-Hill, Theresa, Huang, Da Wei, Ovcharov, Pavel, Nomie, Krystle, Nuzhdina, Ekaterina, Kotlov, Nikita, Ataullakhanov, Ravshan, Fowler, Nathan, Kelly, Michael, Muppidi, Jagan, Davis, Jeremy L, Hernandez, Jonathan M, Wilson, Wyndham H, Jaffe, Elaine S, Staudt, Louis M, Roschewski, Mark, Germain, Ronald N

“…Follicular lymphoma (FL) is a generally incurable malignancy that evolves from developmentally blocked germinal center (GC) B cells. To promote survival and…”
Get more information

Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity by Miheecheva, Natalia, Postovalova, Ekaterina, Lyu, Yang, Ramachandran, Akshaya, Bagaev, Alexander, Svekolkin, Viktor, Galkin, Ilia, Zyrin, Vladimir, Maximov, Vladislav, Lozinsky, Yaroslav, Isaev, Sergey, Ovcharov, Pavel, Shamsutdinova, Diana, Cheng, Emily H., Nomie, Krystle, Brown, Jessica H., Tsiper, Maria, Ataullakhanov, Ravshan, Fowler, Nathan, Hsieh, James J.

“…Intratumor heterogeneity (ITH) represents a major challenge for anticancer therapies. An integrated, multidimensional, multiregional approach dissecting ITH of…”
Get full text

Integrated-omics of MRI-visible and -invisible prostate cancer identifies molecular correlations with clinical outcome by Kim, Eric, Miheecheva, Natalia, Ramachandran, Akshaya, Lyu, Yang, Galkin, Ilia, Svekolkin, Viktor, Postovalova, Ekaterina, Bagaev, Alexander, Nomie, Krystle, Ogloblina, Anna, Frenkel, Felix, Ataullakhanov, Ravshan, Hsieh, James J, Pachynski, Russell Kent

“…Abstract only e17506 Background: The inclusion of multiparametric MRI (mpMRI) to prostate cancer (PCa) diagnostics has increased the detection rate and has…”
Get full text

Integrated single-cell spatial multi-omics of intratumor heterogeneity in renal cell carcinoma by Hsieh, James J, Miheecheva, Natalia, Ramachandran, Akshaya, Lyu, Yang, Galkin, Ilia, Svekolkin, Viktor, Postovalova, Ekaterina, Bagaev, Alexander, Lozinsky, Yaroslav, Zyrin, Vladimir, Zaitsev, Aleksandr, Nuzhdina, Katerina, Nomie, Krystle, Ogloblina, Anna, Frenkel, Felix, Ataullakhanov, Ravshan

“…Abstract only e17106 Background: Clear cell renal cell carcinoma (ccRCC) exhibits conspicuous intratumor heterogeneity (ITH) - a driver of tumor evolution and…”
Get full text

High Dimensional Tissue-Based Spatial Analysis of the Tumor Microenvironment of Follicular Lymphoma Reveals Unique Immune Niches inside Malignant Follicles by Villasboas, Jose C, Mondello, Patrizia, Fama, Angelo, Larson, Melissa C., Feldman, Andrew L., Yang, Zhi-Zhang, Galkin, Ilia, Svekolkin, Viktor, Postovalova, Ekaterina, Bagaev, Alexander, Ovcharov, Pavel, Varlamova, Arina, Huet, Sarah, Tesson, Bruno, McGrath, Kaitlyn R, Slager, Susan L., Syrbu, Sergei, Novak, Anne J., Habermann, Thomas M., Witzig, Thomas E., Nowakowski, Grzegorz S., Salles, Gilles, Cerhan, James R., Ansell, Stephen M.

“…Background The importance of the immune system in modulating the trajectory of lymphoma outcomes has been increasingly recognized. We recently showed that CD4+…”
Get full text

Integration and Iteration: Using Advanced, High-Content Imaging and Single-Cell Gene Expression Analysis to Uncover Unique Aspects of Follicular Lymphoma Biology by Radtke, Andrea J., Shaffer, Arthur L., Pittaluga, Stefania, Bagaev, Alexander, Thakur, Nishant, Davies-Hill, Theresa, Plotnikova, Olga, Galkin, Ilia, Postovalova, Ekaterina, Svekolkin, Viktor, Isaev, Sergei, Lozinsky, Yaroslav, Meerson, Mark, Varlamova, Arina, Ovcharov, Pavel, Polyakova, Margarita, Nomie, Krystle, Nuzhdina, Ekaterina, Kotlov, Nikita, Tsiper, Maria, Frenkel, Felix, Attaulakhanov, Ravshan, Fowler, Nathan H, Yaniv, Ziv, Lowekamp, Bradley C, Kelly, Michael, Dadkhah, Ezzat, Huang, Da Wei, Muppidi, Jagan R., Jaffe, Elaine S., Wilson, Wyndham H., Staudt, Louis M., Germain, Ronald N., Roschewski, Mark

“…BACKGROUND: Follicular lymphoma (FL) is an indolent malignancy of germinal center B-cell origin. FL patients experience remarkable heterogeneity in their…”
Get full text

Abstract 6151: Tumor microenvironment heterogeneity identifies potential biomarkers of response in ER-positive breast cancers treated with palbociclib by Bruttan, Maria, Sanati, Souzan, Belozerova, Anna, Galkin, Ilia, Ramachandran, Akshaya, Ovcharov, Pavel, Perelman, Grigory, Svekolkin, Viktor, Postovalova, Ekaterina, Bagaev, Alexander, Nomie, Krystle, Thomas, Shana, Hoog, Jeremy, Ataullakhanov, Ravshan, Hsieh, James, Ma, Cynthia

“…Abstract Despite the breast cancer microenvironment being recognized as a critical participant in tumor progression and therapeutic response, current…”
Get full text