Search Results - "Galizzi, Melina"

Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes by Saeui, Christopher T, Nairn, Alison V, Galizzi, Melina, Douville, Christopher, Gowda, Prateek, Park, Marian, Dharmarha, Vrinda, Shah, Sagar R, Clarke, Amelia, Austin, Melissa, Moremen, Kelley W, Yarema, Kevin J

“…In this report we use 'high-flux' tributanoyl-modified N-acetylmannosamine (ManNAc) analogs with natural N-acetyl as well as non-natural azido- and alkyne…”
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Squalene synthase as a target for Chagas disease therapeutics by Shang, Na, Li, Qian, Ko, Tzu-Ping, Chan, Hsiu-Chien, Li, Jikun, Zheng, Yingying, Huang, Chun-Hsiang, Ren, Feifei, Chen, Chun-Chi, Zhu, Zhen, Galizzi, Melina, Li, Zhu-Hong, Rodrigues-Poveda, Carlos A, Gonzalez-Pacanowska, Dolores, Veiga-Santos, Phercyles, de Carvalho, Tecia Maria Ulisses, de Souza, Wanderley, Urbina, Julio A, Wang, Andrew H-J, Docampo, Roberto, Li, Kai, Liu, Yi-Liang, Oldfield, Eric, Guo, Rey-Ting

“…Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous…”
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Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases by Martínez-Flórez, Alba, Galizzi, Melina, Izquierdo, Luis, Bustamante, Juan M., Rodriguez, Ana, Rodriguez, Fernando, Rodríguez-Cortés, Alhelí, Alberola, Jordi

“…Malaria, leishmaniasis and trypanosomiasis are arthropod-borne, parasitic diseases that constitute a major global health problem. They are generally found in…”
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Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence by Galizzi, Melina, Bustamante, Juan M., Fang, Jianmin, Miranda, Kildare, Soares Medeiros, Lia C., Tarleton, Rick L., Docampo, Roberto

“…Summary Trypanosoma cruzi infection leads to development of a chronic disease but the mechanisms that the parasite utilizes to establish a persistent infection…”
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Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents by Recher, Marion, Barboza, Alejandro P., Li, Zhu-Hong, Galizzi, Melina, Ferrer-Casal, Mariana, Szajnman, Sergio H., Docampo, Roberto, Moreno, Silvia N.J., Rodriguez, Juan B.

“…As part of our efforts aimed at searching for new antiparasitic agents, 2-alkylmercaptoethyl-1,1-bisphosphonate derivatives were synthesized and evaluated…”
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Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase by Demoro, Bruno, Caruso, Francesco, Rossi, Miriam, Benítez, Diego, González, Mercedes, Cerecetto, Hugo, Galizzi, Melina, Malayil, Leena, Docampo, Roberto, Faccio, Ricardo, Mombrú, Alvaro W, Gambino, Dinorah, Otero, Lucía

“…In the search for a pharmacological answer to treat Chagas disease, eight metal complexes with two bioactive bisphosphonates, alendronate (Ale) and pamidronate…”
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Phosphonium lipocations as antiparasitic agents by Long, Timothy E., Lu, Xiao, Galizzi, Melina, Docampo, Roberto, Gut, Jiri, Rosenthal, Philip J.

“…Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of…”
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Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase by Rosso, Valeria S., Szajnman, Sergio H., Malayil, Leena, Galizzi, Melina, Moreno, Silvia N.J., Docampo, Roberto, Rodriguez, Juan B.

“…The effect of long-chain 2-alkylaminoethyl-1,1-bisphosphonates against proliferation of the clinically more relevant form of Trypanosoma cruzi, the etiologic…”
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Calcium uptake and proton transport by acidocalcisomes of Toxoplasma gondii by Rohloff, Peter, Miranda, Kildare, Rodrigues, Juliany C F, Fang, Jianmin, Galizzi, Melina, Plattner, Helmut, Hentschel, Joachim, Moreno, Silvia N J

“…Acidocalcisomes are acidic calcium stores found in diverse organisms, being conserved from bacteria to humans. They possess an acidic matrix that contains…”
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Trypanosoma cruzi: Antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro by Mezencev, Roman, Galizzi, Melina, Kutschy, Peter, Docampo, Roberto

“…American trypanosomiasis (Chagas disease) continues to be a significant public health problem, and the therapeutic potential of current antichagasic agents…”
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Cell Line-, Protein-, and Sialoglycosite-Specific Control of Flux-Based Sialylation in Human Breast Cells: Implications for Cancer Progression by Saeui, Christopher T, Cho, Kyung-Cho, Dharmarha, Vrinda, Nairn, Alison V, Galizzi, Melina, Shah, Sagar R, Gowda, Prateek, Park, Marian, Austin, Melissa, Clarke, Amelia, Cai, Edward, Buettner, Matthew J, Ariss, Ryan, Moremen, Kelley W, Zhang, Hui, Yarema, Kevin J

“…Sialylation, a post-translational modification that impacts the structure, activity, and longevity of glycoproteins has been thought to be controlled primarily…”
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Developmental Expression of a Trypanosoma cruzi Phosphoinositide-Specific Phospholipase C in Amastigotes and Stimulation of Host Phosphoinositide Hydrolysis by de Paulo Martins, Vicente, Galizzi, Melina, Salto, Maria Laura, Docampo, Roberto, Moreno, Silvia N.J

“…Phosphoinositide phospholipase C (PI-PLC) plays an essential role in cell signaling. A unique Trypanosoma cruzi PI-PLC (TcPI-PLC) is lipid modified in its N…”
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Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase by Szajnman, Sergio H., Garcı´a Liñares, Guadalupe E., Li, Zhu-Hong, Jiang, Cuiying, Galizzi, Melina, Bontempi, Esteban J., Ferella, Marcela, Moreno, Silvia N.J., Docampo, Roberto, Rodriguez, Juan B.

“…The effect of a series of 2-alkylaminoethyl-1,1-bisphosphonic acids against proliferation of the clinically more relevant form of Trypanosoma cruzi, the…”
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A mutant-cell library for systematic analysis of heparan sulfate structure–function relationships by Qiu, Hong, Shi, Songshan, Yue, Jingwen, Xin, Meng, Nairn, Alison V., Lin, Lei, Liu, Xinyue, Li, Guoyun, Archer-Hartmann, Stephanie A., Dela Rosa, Mitche, Galizzi, Melina, Wang, Shunchun, Zhang, Fuming, Azadi, Parastoo, van Kuppevelt, Toin H., Cardoso, Wellington V., Kimata, Koji, Ai, Xingbin, Moremen, Kelley W., Esko, Jeffrey D., Linhardt, Robert J., Wang, Lianchun

“…Heparan sulfate (HS) is a complex linear polysaccharide that modulates a wide range of biological functions. Elucidating the structure–function relationship of…”
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Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins by Park, Diane D, Chen, Jiaxuan, Kudelka, Matthew R, Jia, Nan, Haller, Carolyn A, Kosaraju, Revanth, Premji, Alykhan M, Galizzi, Melina, Nairn, Alison V, Moremen, Kelley W, Cummings, Richard D, Chaikof, Elliot L

“…The pleiotropic functions of macrophages in immune defense, tissue repair, and maintenance of tissue homeostasis are supported by the heterogeneity in…”
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SQ109, a new drug lead for Chagas disease by Veiga-Santos, Phercyles, Li, Kai, Lameira, Lilianne, de Carvalho, Tecia Maria Ulisses, Huang, Guozhong, Galizzi, Melina, Shang, Na, Li, Qian, Gonzalez-Pacanowska, Dolores, Hernandez-Rodriguez, Vanessa, Benaim, Gustavo, Guo, Rey-Ting, Urbina, Julio A, Docampo, Roberto, de Souza, Wanderley, Oldfield, Eric

“…We tested the antituberculosis drug SQ109, which is currently in advanced clinical trials for the treatment of drug-susceptible and drug-resistant…”
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HNK-1 sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan by Sheikh, M Osman, Venzke, David, Anderson, Mary E, Yoshida-Moriguchi, Takako, Glushka, John N, Nairn, Alison V, Galizzi, Melina, Moremen, Kelley W, Campbell, Kevin P, Wells, Lance

“…Abstract Mutations in multiple genes required for proper O-mannosylation of α-dystroglycan are causal for congenital/limb-girdle muscular dystrophies and…”
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Diagnosis of Trypanosoma cruzi Infection Status using Saliva of Infected Subjects by Cortes-Serra, Nuria, Pinazo, Maria-Jesus, de la Torre, Leonardo, Galizzi, Melina, Gascon, Joaquim, Bustamante, Juan Manuel

“…Chagas disease has the highest prevalence of any parasitic disease in the Americas, affecting 6-7 million people. Conventional diagnosis requires a…”
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Risedronate metal complexes potentially active against Chagas disease by Demoro, Bruno, Caruso, Francesco, Rossi, Miriam, Benítez, Diego, Gonzalez, Mercedes, Cerecetto, Hugo, Parajón-Costa, Beatriz, Castiglioni, Jorge, Galizzi, Melina, Docampo, Roberto, Otero, Lucía, Gambino, Dinorah

“…In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread Latin American parasitic disease, novel complexes of the…”
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Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in T rypanosoma cruzi persistence by Galizzi, Melina, Bustamante, Juan M., Fang, Jianmin, Miranda, Kildare, Soares Medeiros, Lia C., Tarleton, Rick L., Docampo, Roberto

“…T rypanosoma cruzi infection leads to development of a chronic disease but the mechanisms that the parasite utilizes to establish a persistent infection…”
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