Search Results - "Galione, A."

NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores by Galione, A

“…NAADP (nicotinic acid-adenine dinucleotide phosphate) is a recently described Ca2+-mobilizing molecule. First characterized in the sea urchin egg, it has been…”
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N-acetyl-L-leucine for Niemann-Pick type C: a multinational double-blind randomized placebo-controlled crossover study by Fields, T, M Bremova, T, Billington, I, Churchill, G C, Evans, W, Fields, C, Galione, A, Kay, R, Mathieson, T, Martakis, K, Patterson, M, Platt, F, Factor, M, Strupp, M

“…Niemann-Pick disease type C (NPC) is a rare autosomal recessive neurodegenerative lysosomal disease characterized by multiple symptoms such as progressive…”
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A master protocol to investigate a novel therapy acetyl-L-leucine for three ultra-rare neurodegenerative diseases: Niemann-Pick type C, the GM2 gangliosidoses, and ataxia telangiectasia by Fields, T, Patterson, M, Bremova-Ertl, T, Belcher, G, Billington, I, Churchill, G C, Davis, W, Evans, W, Flint, S, Galione, A, Granzer, U, Greenfield, J, Karl, R, Kay, R, Lewi, D, Mathieson, T, Meyer, T, Pangonis, D, Platt, F M, Tsang, L, Verburg, C, Factor, M, Strupp, M

“…The lack of approved treatments for the majority of rare diseases is reflective of the unique challenges of orphan drug development. Novel methodologies,…”
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Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes by Kashir, Junaid, Jones, Celine, Lee, Hoi Chang, Rietdorf, Katja, Nikiforaki, Dimitra, Durrans, Claire, Ruas, Margarida, Tee, Sze Tian, Heindryckx, Bjorn, Galione, Antony, De Sutter, Petra, Fissore, Rafael A., Parrington, John, Coward, Kevin

“…BACKGROUND Mammalian oocyte activation occurs via a series of intracellular calcium (Ca2+) oscillations thought to be induced by a sperm-specific phospholipase…”
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The Role of Calcium and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) in Human Osteoclast Formation and Resorption by Cheng, X., Hookway, E. S., Kashima, T., Oppermann, U., Galione, A., Athanasou, N. A.

“…Osteoclasts are specialised bone resorbing cells which form by fusion of circulating mononuclear phagocyte precursors. Bone resorption results in the release…”
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Modeling of gradient index solar selective surfaces for solar thermal applications by Davoine, F., Galione, P.A., Ramos-Barrado, J.R., Leinen, D., Martín, F., Dalchiele, E.A., Marotti, R.E.

“…► Simulation of selective surface optical properties for solar thermal applications. ► Composite materials using three constituents Bruggeman effective medium…”
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The NAADP Receptor: New Receptors or New Regulation? by Galione, Antony, Petersen, Ole H

“…Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent calcium mobilizing messenger yet discovered. Its action has now been reported in a…”
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Fixed-grid numerical modeling of melting and solidification using variable thermo-physical properties – Application to the melting of n-Octadecane inside a spherical capsule by Galione, P A, Lehmkuhl, O, Rigola, J, Oliva, A

“…A fixed-grid enthalpy model for unstructured meshes and explicit time integration schemes (Galione et al., 2014) is here extended for taking into account the…”
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Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand by Patel, S, Churchill, G C, Galione, A

“…Nicotinic acid-adenine dinucleotide phosphate (NAADP) is a novel and potent Ca(2+)-mobilizing agent in sea urchin eggs and other cell types. Little is known,…”
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Multi-layered solid-PCM thermocline thermal storage for CSP. Numerical evaluation of its application in a 50 MWe plant by Galione, P A, Pérez-Segarra, CD, Rodríguez, I, Torras, S, Rigola, J

“…Thermocline storage concept is considered as a possible solution to reduce the cost of thermal storage in concentrated solar power (CSP) plants. Recently, a…”
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The NAADP receptor: commentary on Billington et al by Galione, A, Parrington, J, Dowden, J

“…NAADP is a recently described calcium‐mobilizing messenger. First discovered as a potent calcium‐releasing molecule in sea urchin eggs, its actions have now…”
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NAADP receptors by Galione, Antony

“…Of the established Ca(2+) mobilizing messengers, NAADP is arguably the most tantalizing. It is the most potent, often efficacious at low nanomolar…”
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Pharmacological characterization of the putative cADP-ribose receptor by Thomas, J M, Masgrau, R, Churchill, G C, Galione, A

“…cADP-ribose (cADPR), a naturally occurring metabolite of NAD(+), has been shown to be an important regulator of intracellular Ca(2+) release. Considerable…”
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Fixed-Grid Modeling of Solid-Liquid Phase Change in Unstructured Meshes Using Explicit Time Schemes by Galione, P. A., Lehmkuhl, O., Rigola, J., Oliva, A.

“…Fixed-grid enthalpy models have been used extensively for solid-liquid phase-change computational fluid dynamics (CFD) simulations with implicit time schemes…”
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GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation by Shigeto, Makoto, Ramracheya, Reshma, Tarasov, Andrei I, Cha, Chae Young, Chibalina, Margarita V, Hastoy, Benoit, Philippaert, Koenraad, Reinbothe, Thomas, Rorsman, Nils, Salehi, Albert, Sones, William R, Vergari, Elisa, Weston, Cathryn, Gorelik, Julia, Katsura, Masashi, Nikolaev, Viacheslav O, Vennekens, Rudi, Zaccolo, Manuela, Galione, Antony, Johnson, Paul R V, Kaku, Kohei, Ladds, Graham, Rorsman, Patrik

“…Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated…”
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Modulation of Xenopus embryo mesoderm-specific gene expression and dorsoanterior patterning by receptors that activate the phosphatidylinositol cycle signal transduction pathway by Ault, K T, Durmowicz, G, Galione, A, Harger, P L, Busa, W B

“…A role for the phosphatidylinositol (PI) cycle signal transduction pathway in Xenopus mesoderm induction has been revealed by observations of PI cycle…”
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Regenerative and non-regenerative calcium transients in hamster eggs triggered by inositol 1,4,5-trisphosphate by Galione, A, Swann, K, Georgiou, P, Whitaker, M

“…1. Inositol 1,4,5-trisphosphate (InsP3) injected into unfertilized golden hamster eggs elicits a hyperpolarizing response (HR) that is due to stimulation of…”
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Origin of solar thermal selectivity and interference effects in nickel–alumina nanostructured films by Galione, P.A., Baroni, A.L., Ramos-Barrado, J.R., Leinen, D., Martín, F., Marotti, R.E., Dalchiele, E.A.

“…Selective surfaces for solar to thermal conversion were studied for understanding the main parameters affecting selectivity. For this purpose samples of Ni…”
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The relative order of IP3 sensitivity of types 1 and 3 IP3 receptors is pH dependent by De Smet, P, Parys, J B, Vanlingen, S, Bultynck, G, Callewaert, G, Galione, A, De Smedt, H, Missiaen, L

“…The type-3 inositol 1,4,5-trisphosphate (IP3) receptor, in contrast to the type-1 IP3 receptor (IP3R), is not stimulated by sulfhydryl oxidation and is less…”
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NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs by Churchill, Grant C, Okada, Yuhei, Thomas, Justyn M, Genazzani, Armando A, Patel, Sandip, Galione, Antony

“…Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes Ca(2+) in many cells and species. Unlike other Ca(2+)-mobilizing messengers, NAADP mobilizes…”
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