Search Results - "Galinsky, R E"

Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2 by Yim, CY, Hibbs, JB, Jr, McGregor, JR, Galinsky, RE, Samlowski, WE

“…IL-2 therapy can induce marked oxidative stress via reactive oxygen and nitrogen intermediates. Glutathione, the major intracellular reductant, may become rate…”
Get full text

Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency by Bonkovsky, H L, Kane, R E, Jones, D P, Galinsky, R E, Banner, B

“…A 67-yr-old man with chronic cardiopulmonary disease exhibited severe hepatic and moderately severe renal injury after short-term ingestion of therapeutic…”
Get more information

Dose-related distribution of codeine and its metabolites into rat hair by Gygi, S P, Colon, F, Raftogianis, R B, Galinsky, R E, Wilkins, D G, Rollins, D E

“…Drugs and endogenous compounds may be incorporated into the matrix of a growing hair shaft. However, the relationship between incorporation and dose or time…”
Get more information

Uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats: intravenous infusion studies by Anderson, B D, Hoesterey, B L, Baker, D C, Galinsky, R E

“…The pharmacokinetics of 2',3'-dideoxyinosine (ddl) and its distribution to plasma, brain tissue and cerebrospinal fluid (CSF) were determined during and after…”
Get more information

Probenecid enhances central nervous system uptake of 2',3'-dideoxyinosine by inhibiting cerebrospinal fluid efflux by Galinsky, R E, Flaharty, K K, Hoesterey, B L, Anderson, B D

“…The effects of probenecid on the pharmacokinetics of 2',3'-dideoxyinosine (ddl) and on the distribution of ddl to cerebrospinal fluid (CSF) and brain tissue…”
Get more information

Role of glutathione turnover in drug sulfation: differential effects of diethylmaleate and buthionine sulfoximine on the pharmacokinetics of acetaminophen in the rat by Galinsky, R E

“…The purpose of this investigation was to examine the role of altered glutathione turnover in regulating sulfation. After diethylmaleate (3.9 mmol/kg i.p.) or…”
Get more information

Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: Effects of transjugular intrahepatic portosystemic shunts by Chalasani, Naga, Gorski, J.Christopher, Patel, Nilesh H., Hall, Stephen D., Galinsky, Raymond E.

“…Transjugular intrahepatic portosystemic shunt (TIPS) is performed to treat some complications of cirrhosis. This study investigated the effects of cirrhosis…”
Get full text

Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats by Hoesterey, B L, Galinsky, R E, Anderson, B D

“…Dose dependence in the plasma pharmacokinetics of 2',3'-dideoxyinosine (ddI) was examined during and after 2-hr iv infusions in rats at infusion rates of 12.4,…”
Get more information

Effect of aging on drug-metabolizing enzymes important in acetaminophen elimination by Galinsky, R E, Kane, R E, Franklin, M R

“…The effects of aging on selected drug-metabolizing enzyme activities, the pattern of phenol and bile salt sulfotransferase isoenzymes and the pharmacokinetics…”
Get more information

Plasma concentrations of inorganic sulfate in Alzheimer's disease by EDWARDS, D. J, ALTMAN, H. J, GALINSKY, R. E

“…Recent reports have suggested that plasma concentrations of inorganic sulfate may be lower in patients with Alzheimer's disease (AD). We measured sulfate…”
Get full text

Effect of lipid-free total parenteral nutrition on hepatic drug conjugation in rats by Raftogianis, R B, Franklin, M R, Galinsky, R E

“…The effect of total parenteral nutrition (TPN) on drug conjugation in male Sprague-Dawley rats was examined using a nutrition solution composed of amino acids…”
Get more information

Drug metabolizing enzyme changes after chronic buthionine sulfoximine exposure modify acetaminophen disposition in rats by Manning, B W, Franklin, M R, Galinsky, R E

“…This study examined the effects of prolonged exposure to buthionine sulfoximine (BSO) on 1) the overall elimination pharmacokinetics of acetaminophen; 2) the…”
Get more information

Effect of aging on hepatic biotransformation in female Fischer 344 rats: changes in sulfotransferase activities are consistent with known gender-related changes in pituitary growth hormone secretion in aging animals by Galinsky, R E, Johnson, D H, Kane, R E, Franklin, M R

“…The effect of aging on hepatic drug conjugation in 5- to 6-, 12- to 13- and 22- to 23-month-old female Fischer 344 rats was examined. The overall disposition…”
Get more information

Brain and cerebrospinal fluid uptake of zidovudine (AZT) in rats after intravenous injection by Galinsky, R E, Hoesterey, B L, Anderson, B D

“…Uptake kinetics of zidovudine into cerebrospinal fluid (CSF) and brain tissue were determined in adult Sprague Dawley male rats after single intravenous…”
Get more information

Effect of total parenteral nutrition containing lipid calories on hepatic drug metabolism in rats by Raftogianis, R B, Franklin, M R, Galinsky, R E

Get more information

Suppression of acetaminophen conjugation and of conjugate elimination in the rat by metyrapone, a classical P-450 inhibitor by Galinsky, R E, Corcoran, G B

“…This study examined the effects of metyrapone on the overall elimination of acetaminophen and on the individual processes principally responsible for…”
Get more information

The Depression of Hepatic Drug Conjugation Reactions in Rats After Lipid-Free Total Parenteral Nutrition Administered via the Portal Vein by Raftogianis, Rebecca B., Franklin, Michael R., Galinsky, Raymond E.

“…Background: Total parenteral nutrition provides nutrition support in patients who are unable to eat. Long-term parenteral nutrition is accompanied by…”
Get full text

Unexpected accumulation of acyclovir in breast milk with estimation of infant exposure by Lau, R J, Emery, M G, Galinsky, R E

“…Although acyclovir is prescribed to women of reproductive age, no information currently exists regarding the advisability of its use in lactating women. This…”
Get more information

Intrathecal administration of interleukin-2 for meningeal carcinomatosis due to malignant melanoma: sequential evaluation of intracranial pressure, cerebrospinal fluid cytology, and cytokine induction by Samlowski, W E, Park, K J, Galinsky, R E, Ward, J H, Schumann, G B

“…A patient with interleukin (IL)-2 responsive metastatic melanoma developed meningeal carcinomatosis. Treatment was attempted with intrathecal (i.t.) IL-2 (5…”
Get more information

Effect of cyclosporine on hepatic oxidative and conjugative metabolism in rats by Galinsky, R E, Alexander, D P, Franklin, M R

Get more information