Search Results - "Gales, Tracy"

Species-specific Inflammatory Responses as a Primary Component for the Development of Glomerular Lesions in Mice and Monkeys Following Chronic Administration of a Second-generation Antisense Oligonucleotide by Frazier, Kendall S., Sobry, Cécile, Derr, Victoria, Adams, Mike J., Besten, Cathaline Den, Kimpe, Sjef De, Francis, Ian, Gales, Tracy L., Haworth, Richard, Maguire, Shaun R., Mirabile, Rosanna C., Mullins, David, Palate, Bernard, Doorten, Yolanda Ponstein-Simarro, Ridings, James E., Scicchitano, Marshall S., Silvano, Jérémy, Woodfine, Jennie

“…Chronic administration of drisapersen, a 2′-OMe phosphorothioate antisense oligonucleotide (AON) to mice and monkeys resulted in renal tubular accumulation,…”
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Differences in Effects on Myocardium and Mitochondria by Angiogenic Inhibitors Suggest Separate Mechanisms of Cardiotoxicity by French, Kevin J., Coatney, Robert W., Renninger, Jon P., Hu, Catherine X., Gales, Tracy L., Zhao, Shufang, Storck, Laura M., Davis, Charles B., McSurdy-Freed, Jeanelle, Chen, Emile, Frazier, Kendall S.

“…Several multikinase angiogenesis inhibitors demonstrate mitochondrial and/or cardiovascular toxicity, suggesting an on-target pharmacologic effect. To evaluate…”
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Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier by Tran, Thuy Thanh, Mittal, Aditya, Gales, Tracy, Maleeff, Beverly, Aldinger, Tanya, Polli, Joseph W, Ayrton, Andrew, Ellens, Harma, Bentz, Joe

“…Knowledge of the passive permeability coefficient for new drugs is useful for estimating the fraction absorbed across the gastrointestinal tract. The commonly…”
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Effects of Troglitazone on HepG2 Viability and Mitochondrial Function by Tirmenstein, Mark A., Hu, Catherine X., Gales, Tracy L., Maleeff, Beverly E., Narayanan, Padma K., Kurali, Edit, Hart, Timothy K., Thomas, Heath C., Schwartz, Lester W.

“…Troglitazone (TRO), a member of the thiazolidinedione class of drugs, has been associated with hepatotoxicity in patients. The following in vitro study was…”
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Novel Vascular Lesions in Mice Given a Non-Peptide Vitronectin Receptor Antagonist by Rehm, Sabine, Thomas, Roberta A., Smith, Kim S., Mirabile, Rosanna C., Gales, Tracy L., Eustis, Scot L., Boyce, Rogely W.

“…Novel vascular lesions were observed in mice given an αvβ3, αvβ5 receptor antagonist (SB-273005) for up to 3 months. Vascular smooth muscle cell (VSMC)…”
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Measles Virus Spread between Neurons Requires Cell Contact but Not CD46 Expression, Syncytium Formation, or Extracellular Virus Production by Lawrence, D M, Patterson, C E, Gales, T L, D'Orazio, J L, Vaughn, M M, Rall, G F

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterizing the Distribution of a Stimulator of Interferon Genes Agonist and Its Metabolites in Mouse Liver by Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry by Xie, Fang, Gales, Tracy, Ringenberg, M A, Wolf, Amaya I, Groseclose, M Reid

“…A STING (stimulator of interferon genes) agonist GSK3996915 under investigation in early discovery for hepatitis B was orally dosed to a mouse model for…”
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The Mouse Pale Ear (ep) Mutation is the Homologue of Human Hermansky-Pudlak Syndrome by Gardner, John M., Wildenberg, Scott C., Keiper, Natalie M., Novak, Edward K., Rusiniak, Michael E., Swank, Richard T., Puri, Neelu, Finger, Joshua N., Hagiwara, Nobuko, Lehman, Anne L., Gales, Tracy L., Bayer, Manfred E., King, Richard A., Brilliant, Murray H.

“…The recessive mutation at the pale ear (ep) locus on mouse chromosome 19 was found to be the homologue of human Hermansky-Pudlak syndrome (HPS). A positional…”
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Congenital Unilateral Renal Aplasia in a Cynomolgus Monkey (Macaca fascicularis) With Investigation Into Potential Pathogenesis by Obert, Leslie A, Suttie, Andrew, Abdi, Mohamoud, Gales, Tracy, Dwyer, David, Fritz, Wayne, Robertson, Nicola, Weir, Lucinda, Frazier, Kendall

“…We describe and characterize unilateral renal aplasia in a cynomolgus monkey (Macaca fascicularis) from a chronic toxicology study adding to the limited…”
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Abstract PR-9: Differences in effects on myocardium and mitochondria by VEGF receptor inhibitors suggest separate mechanisms of cardiotoxicity by French, Kevin, Hu, Catherine, Kumar, Rakesh, Renninger, Jon, Gales, Tracy, Coatney, Robert, Frazier, Kendall

“…Abstract Reports have implicated vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors with mitochondrial injury and/or subsequent…”
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Primary combined malignant melanoma and ductal carcinoma of the breast: A report of two cases by Padmore, Ruth F., Lara, Jonathan F., Ackerman, Deborah J., Gales, Tracy, Sigurdson, Elin R., Ehya, Hormoz, Cooper, Harry S., Patchefsky, Arthur S.

“…BACKGROUND Tumors consisting of a combination of malignant melanoma and carcinoma are very rare. The authors report two such cases occurring as primary breast…”
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Myoclonic epilepsy and ragged-red fibers with cytochrome oxidase deficiency: neuropathology, biochemistry, and molecular genetics by Lombes, A, Mendell, J R, Nakase, H, Barohn, R J, Bonilla, E, Zeviani, M, Yates, A J, Omerza, J, Gales, T L, Nakahara, K

“…A 36-year-old man with myoclonic epilepsy and ragged-red fibers (MERRF) died after more than 18 years of follow-up study. He was 1 of 3 affected siblings and…”
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Amyloid filaments in inclusion body myositis. Novel findings provide insight into nature of filaments by Mendell, J R, Sahenk, Z, Gales, T, Paul, L

“…Inclusion body myositis (IBM) represents a serious debilitating disease of muscle without identifiable cause or treatment. Muscle biopsy specimens have…”
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