Search Results - "Gales, Sonya"

Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey by Yu, Hong, Barrass, Nigel, Gales, Sonya, Lenz, Eva, Parry, Tony, Powell, Helen, Thurman, Dale, Hutchison, Michael, Wilson, Ian D., Bi, Luke, Qiao, Junwen, Qin, Qiuping, Ren, Jin

“…Abstract 1. Paracetamol overdose remains the leading cause of acute liver failure in humans. This study was undertaken in cynomolgus monkeys to study the…”
Get full text

Abstract 1718: Design and optimization of a dendrimer-conjugated dual Bcl-2/Bcl-xL inhibitor, AZD0466, with improved therapeutic index by Ashford, Marianne B., Balachander, Srividya B., Graham, Lorraine, Grant, Iain, Gibbons, Francis D., Hill, Kathryn J., Harmer, Alexander R., Gales, Sonya, Redmond, Sean, Kelly, Brian, McCoull, William, Wen, Shenghua, Wild, Martin, Gangl, Eric, Owen, David J., Davies, Barry R.

“…Abstract Dual Bcl-2/Bcl-xL inhibitors are expected to deliver therapeutic benefit in many hematological and solid tumors, but their clinical application has…”
Get full text

Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners by Doshi, Aatman S, Cantin, Susan, Hernandez, Marylens, Srinivasan, Srimathi, Tentarelli, Sharon, Griffin, Matthew, Wang, Yanjun, Pop-Damkov, Petar, Prickett, Laura B, Kankkonen, Cecilia, Shen, Minhui, Martin, Maryann San, Wu, Song, Castaldi, M Paola, Ghadially, Hormas, Varnes, Jeffrey, Gales, Sonya, Henry, David, Hoover, Clare, Mele, Deanna A, Simpson, Iain, Gangl, Eric T, Mlynarski, Scott N, Finlay, M Raymond V, Drew, Lisa, Fawell, Stephen E, Shao, Wenlin, Schuller, Alwin G

“…Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid…”
Get full text

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy by Patterson, Claire M., Balachander, Srividya B., Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J., Gibbons, Francis D., Hennessy, Edward J., Kemmitt, Paul, Harmer, Alexander R., Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J. Paul, Schuller, Alwin G., Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E., Saeh, Jamal, Davies, Barry R., Owen, David J., Ashford, Marianne B.

“…Dual Bcl-2/Bcl-x L inhibitors are expected to deliver therapeutic benefit in many haematological and solid malignancies, however, their use is limited by…”
Get full text

Design and optimisation of dendrimer-conjugated Bcl-2/x L inhibitor, AZD0466, with improved therapeutic index for cancer therapy by Patterson, Claire M, Balachander, Srividya B, Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J, Gibbons, Francis D, Hennessy, Edward J, Kemmitt, Paul, Harmer, Alexander R, Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J Paul, Schuller, Alwin G, Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E, Saeh, Jamal, Davies, Barry R, Owen, David J, Ashford, Marianne B

“…Dual Bcl-2/Bcl-x inhibitors are expected to deliver therapeutic benefit in many haematological and solid malignancies, however, their use is limited by…”
Get full text