Search Results - "Galenkamp, Nicole Stéphanie"

Directional conformer exchange in dihydrofolate reductase revealed by single-molecule nanopore recordings by Galenkamp, Nicole Stéphanie, Biesemans, Annemie, Maglia, Giovanni

“…Conformational heterogeneity is emerging as a defining characteristic of enzyme function. However, understanding the role of protein conformations requires…”
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Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores by Galenkamp, Nicole Stéphanie, Soskine, Misha, Hermans, Jos, Wloka, Carsten, Maglia, Giovanni

“…Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of…”
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Current Blockades of Proteins inside Nanopores for Real-Time Metabolome Analysis by Zernia, Sarah, van der Heide, Nieck Jordy, Galenkamp, Nicole Stéphanie, Gouridis, Giorgos, Maglia, Giovanni

“…Biological nanopores are emerging as powerful and low-cost sensors for real-time analysis of biological samples. Proteins can be incorporated inside the…”
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Engineering and Modeling the Electrophoretic Trapping of a Single Protein Inside a Nanopore by Willems, Kherim, Ruić, Dino, Biesemans, Annemie, Galenkamp, Nicole Stéphanie, Van Dorpe, Pol, Maglia, Giovanni

“…The ability to confine and to study single molecules has enabled important advances in natural and applied sciences. Recently, we have shown that unlabeled…”
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Single-Molecule Kinetics of Growth and Degradation of Cell-Penetrating Poly(disulfide)s by Pulcu, Gökçe Su, Galenkamp, Nicole Stéphanie, Qing, Yujia, Gasparini, Giulio, Mikhailova, Ellina, Matile, Stefan, Bayley, Hagan

“…The delivery of therapeutic agents into target cells is a challenging task. Cell penetration and intracellular targeting were recently addressed with…”
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Single-Molecule Sampling of Dihydrofolate Reductase Shows Kinetic Pauses and an Endosteric Effect Linked to Catalysis by Galenkamp, Nicole Stéphanie, Maglia, Giovanni

“…The ability to sample multiple reactions on the same single enzyme is important to link rare intermediates with catalysis and to unravel the role of…”
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Specific Detection of Proteins by a Nanobody-Functionalized Nanopore Sensor by Zhang, Xialin, Galenkamp, Nicole Stéphanie, van der Heide, Nieck Jordy, Moreno, Julián, Maglia, Giovanni, Kjems, Jørgen

“…Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore…”
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Automated Electrical Quantification of Vitamin B1 in a Bodily Fluid using an Engineered Nanopore Sensor by Lucas, Florian Leonardus Rudolfus, Piso, Tjemme Rinze Cornelis, Heide, Nieck Jordy, Galenkamp, Nicole Stéphanie, Hermans, Jos, Wloka, Carsten, Maglia, Giovanni

“…The ability to measure the concentration of metabolites in biological samples is important, both in the clinic and for home diagnostics. Here we present a…”
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Preparation of Cytolysin A (ClyA) Nanopores by Galenkamp, Nicole Stéphanie, Van Meervelt, Veerle, Mutter, Natalie Lisa, van der Heide, Nieck Jordy, Wloka, Carsten, Maglia, Giovanni

“…The ionic currents passing through nanopores can be used to sequence DNA and identify molecules at the single-molecule level. Recently, researchers have…”
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Automated Electrical Quantification of Vitamin B1 in a Bodily Fluid using an Engineered Nanopore Sensor by Lucas, Florian Leonardus Rudolfus, Piso, Tjemme Rinze Cornelis, Heide, Nieck Jordy, Galenkamp, Nicole Stéphanie, Hermans, Jos, Wloka, Carsten, Maglia, Giovanni

“…The ability to measure the concentration of metabolites in biological samples is important, both in the clinic and for home diagnostics. Here we present a…”
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Allostery can convert binding free energies into concerted domain motions in enzymes by Galenkamp, Nicole Stéphanie, Zernia, Sarah, Van Oppen, Yulan B., van den Noort, Marco, Argeitis, Andreas Milias, Maglia, Giovanni

“…Enzymatic mechanisms are typically inferred from structural data. However, understanding enzymes require unravelling the intricate dynamic interplay between…”
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Preparation of Fragaceatoxin C (FraC) Nanopores by Mutter, Natalie Lisa, Huang, Gang, van der Heide, Nieck Jordy, Lucas, Florian Leonardus Rudolfus, Galenkamp, Nicole Stéphanie, Maglia, Giovanni, Wloka, Carsten

“…Biological nanopores are an emerging class of biosensors with high-end precision owing to their reproducible fabrication at the nanometer scale. Most notably,…”
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