Arterial stiffness and influences of the metabolic syndrome: A cross-countries study

Abstract Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specifi...

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Published in:	Atherosclerosis Vol. 233; no. 2; pp. 654 - 660
Main Authors:	Scuteri, Angelo, Cunha, Pedro G, Agabiti Rosei, E, Badariere, Jolita, Bekaert, Sofie, Cockcroft, John R, Cotter, Jorge, Cucca, Francesco, De Buyzere, Marc L, De Meyer, Tim, Ferrucci, Luigi, Franco, Osca, Gale, Nichols, Gillebert, Thierry C, Hofman, A, Langlois, Michel, Laucevicius, Aleksandras, Laurent, Stephane, Mattace Raso, Francesco U.S, Morrell, Cristopher H, Muiesan, Maria Lorenza, Munnery, Margaret M, Navickas, Rokas, Oliveira, Pedro, Orru', Marco, Pilia, Maria Grazia, Rietzschel, Ernst R, Ryliskyte, Ligita, Salvetti, Massimo, Schlessinger, David, Sousa, Nuno, Stefanadis, Christodoulos, Strait, James, Van daele, Caroline, Villa, Isabel, Vlachopoulos, Charalambos, Witteman, Jacqueline, Xaplanteris, Panagiotis, Nilsson, Peter, Lakatta, Edward G
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-04-2014
Subjects:	Aged Anthropometry Arterial stiffness Cardiac and Cardiovascular Systems Cardiovascular Clinical Medicine Comorbidity Cross-cultural comparison Cross-Sectional Studies Diabetes Mellitus - epidemiology Dyslipidemias - epidemiology Europe - epidemiology Female Humans Hypertension - epidemiology Kardiologi Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - epidemiology Metabolic Syndrome - pathology Middle Aged Pulse Wave Analysis Pulse wave velocity Sex Factors Smoking - epidemiology United States - epidemiology Vascular Stiffness Pulse wave velocity Cross-cultural comparison Arterial stiffness Metabolic syndrome
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Summary:	Abstract Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations. We studied 20,570 subjects from 9 cohorts representing 8 different European countries and the US participating in the MARE Consortium. MetS was defined in accordance with NCEP ATPIII criteria as the simultaneous alteration in ≥3 of the 5 components: abdominal obesity ( W ), high triglycerides ( T ), low HDL cholesterol ( H ), elevated blood pressure ( B ), and elevated fasting glucose ( G ). PWV measured in each cohort was “normalized” to account for different acquisition methods. MetS had an overall prevalence of 24.2% (4985 subjects). MetS accelerated the age-associated increase in PWV levels at any age, and similarly in men and women. MetS clusters TBW, GBW, and GTBW are consistently associated with significantly stiffer arteries to an extent similar or greater than observed in subjects with alteration in all the five MetS components – even after controlling for age, sex, smoking, cholesterol levels, and diabetes mellitus – in all the MARE cohorts. In conclusion, different component clusters of MetS showed varying associations with arterial stiffness (PWV).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 full list of Authors in Appendix 1
ISSN:	0021-9150 1879-1484 1879-1484
DOI:	10.1016/j.atherosclerosis.2014.01.041