Search Results - "Gale, Molly"

Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease by Tam, Oliver H, Ostrow, Lyle W, Gale Hammell, Molly

“…Transposable Elements (TEs) are mobile genetic elements whose sequences constitute nearly half of the human genome. Each TE copy can be present in hundreds to…”
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Single-cell RNA-seq analysis identifies markers of resistance to targeted BRAF inhibitors in melanoma cell populations by Ho, Yu-Jui, Anaparthy, Naishitha, Molik, David, Mathew, Grinu, Aicher, Toby, Patel, Ami, Hicks, James, Hammell, Molly Gale

“…Single-cell RNA-seq's (scRNA-seq) unprecedented cellular resolution at a genome-wide scale enables us to address questions about cellular heterogeneity that…”
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Editorial Overview: Endogenous Retroviruses in Development and Disease by Gale Hammell, Molly, Rowe, Helen M

“…As guest editors, we are pleased to present this Special Issue on endogenous retroviruses (ERVs) and their impact on mammalian development and disease [...]…”
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Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance by Gale, Molly, Sayegh, Joyce, Cao, Jian, Norcia, Michael, Gareiss, Peter, Hoyer, Denton, Merkel, Jane S, Yan, Qin

“…Lysine demethylase 5A (KDM5A/RBP2/JARID1A) is a histone lysine demethylase that is overexpressed in several human cancers including lung, gastric, breast and…”
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Ten simple rules for running a successful women-in-STEM organization on an academic campus by Rupert, Deborah D, Nowlan, Alexandra C, Tam, Oliver H, Gale Hammell, Molly

“…The current academic culture facing women in science, technology, engineering, and math (STEM) fields in the United States has sparked the formation of…”
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Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia by Garza, Raquel, Sharma, Yogita, Atacho, Diahann A.M., Thiruvalluvan, Arun, Abu Hamdeh, Sami, Jönsson, Marie E., Horvath, Vivien, Adami, Anita, Ingelsson, Martin, Jern, Patric, Hammell, Molly Gale, Englund, Elisabet, Kirkeby, Agnete, Jakobsson, Johan, Marklund, Niklas

“…Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that…”
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Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds by Horton, John R, Liu, Xu, Gale, Molly, Wu, Lizhen, Shanks, John R, Zhang, Xing, Webber, Philip J, Bell, Joshua S K, Kales, Stephen C, Mott, Bryan T, Rai, Ganesha, Jansen, Daniel J, Henderson, Mark J, Urban, Daniel J, Hall, Matthew D, Simeonov, Anton, Maloney, David J, Johns, Margaret A, Fu, Haian, Jadhav, Ajit, Vertino, Paula M, Yan, Qin, Cheng, Xiaodong

“…The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases removes methyl groups from methylated lysine 4 of histone H3. Accumulating…”
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Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia by Tam, Oliver H., Rozhkov, Nikolay V., Shaw, Regina, Kim, Duyang, Hubbard, Isabel, Fennessey, Samantha, Propp, Nadia, Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Aronica, Eleonora, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert, Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent T., Fagegaltier, Delphine, Harris, Brent T., Ostrow, Lyle W., Phatnani, Hemali, Ravits, John, Dubnau, Josh, Gale Hammell, Molly

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. While several pathogenic…”
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Acquired Resistance of EGFR-Mutant Lung Adenocarcinomas to Afatinib plus Cetuximab Is Associated with Activation of mTORC1 by Pirazzoli, Valentina, Nebhan, Caroline, Song, Xiaoling, Wurtz, Anna, Walther, Zenta, Cai, Guoping, Zhao, Zhongming, Jia, Peilin, de Stanchina, Elisa, Shapiro, Erik M., Gale, Molly, Yin, Ruonan, Horn, Leora, Carbone, David P., Stephens, Philip J., Miller, Vincent, Gettinger, Scott, Pao, William, Politi, Katerina

“…Patients with EGFR-mutant lung adenocarcinomas (LUADs) who initially respond to first-generation tyrosine kinase inhibitors (TKIs) develop resistance to these…”
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TEsmall Identifies Small RNAs Associated With Targeted Inhibitor Resistance in Melanoma by O'Neill, Kathryn, Liao, Wen-Wei, Patel, Ami, Hammell, Molly Gale

“…MicroRNAs (miRNAs) are small 21-22 nt RNAs that act to regulate the expression of mRNA target genes through direct binding to mRNA targets. While miRNAs…”
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DNA methylation in multiple myeloma is weakly associated with gene transcription by Jung, Sungwon, Kim, Seungchan, Gale, Molly, Cherni, Irene, Fonseca, Rafael, Carpten, John, Salhia, Bodour

“…Previous studies have now demonstrated that both genic and global hypomethylation characterizes the multiple myeloma (MM) epigenome. Whether these methylation…”
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LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification by Garza, Raquel, Atacho, Diahann A M, Adami, Anita, Gerdes, Patricia, Vinod, Meghna, Hsieh, PingHsun, Karlsson, Ofelia, Horvath, Vivien, Johansson, Pia A, Pandiloski, Ninoslav, Matas-Fuentes, Jon, Quaegebeur, Annelies, Kouli, Antonina, Sharma, Yogita, Jönsson, Marie E, Monni, Emanuela, Englund, Elisabet, Eichler, Evan E, Gale Hammell, Molly, Barker, Roger A, Kokaia, Zaal, Douse, Christopher H, Jakobsson, Johan

“…The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1)…”
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Mobile genomics: tools and techniques for tackling transposons by O'Neill, Kathryn, Brocks, David, Hammell, Molly Gale

“…Next-generation sequencing approaches have fundamentally changed the types of questions that can be asked about gene function and regulation. With the goal of…”
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An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting by Cao, Jian, Wu, Lizhen, Zhang, Shang-Min, Lu, Min, Cheung, William K C, Cai, Wesley, Gale, Molly, Xu, Qi, Yan, Qin

“…The CRISPR/Cas9 system is a powerful genome editing tool and has been widely used for biomedical research. However, many challenges, such as off-target effects…”
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High-throughput screening to identify inhibitors of lysine demethylases by Gale, Molly, Yan, Qin

“…Lysine demethylases (KDMs) are epigenetic regulators whose dysfunction is implicated in the pathology of many human diseases including various types of cancer,…”
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Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition by Gale, Molly, Li, Yao, Cao, Jian, Liu, Zongzhi Z, Holmbeck, Marissa A, Zhang, Meiling, Lang, Sabine M, Wu, Lizhen, Do Carmo, Mariana, Gupta, Swati, Aoshima, Keisuke, DiGiovanna, Michael P, Stern, David F, Rimm, David L, Shadel, Gerald S, Chen, Xiang, Yan, Qin

“…Acquired resistance to HER2-targeted therapies occurs frequently in HER2 breast tumors and new strategies for overcoming resistance are needed. Here, we report…”
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Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation by Torre, Denis, Fstkchyan, Yesai S, Ho, Jessica Sook Yuin, Cheon, Youngseo, Patel, Roosheel S, Degrace, Emma J, Mzoughi, Slim, Schwarz, Megan, Mohammed, Kevin, Seo, Ji-Seon, Romero-Bueno, Raquel, Demircioglu, Deniz, Hasson, Dan, Tang, Weijing, Mahajani, Sameehan U, Campisi, Laura, Zheng, Simin, Song, Won-Suk, Wang, Ying-Chih, Shah, Hardik, Francoeur, Nancy, Soto, Juan, Salfati, Zelda, Weirauch, Matthew T, Warburton, Peter, Beaumont, Kristin, Smith, Melissa L, Mulder, Lubbertus, Villalta, S Armando, Kessenbrock, Kai, Jang, Cholsoon, Lee, Daeyoup, De Rubeis, Silvia, Cobos, Inma, Tam, Oliver, Hammell, Molly Gale, Seldin, Marcus, Shi, Yongsheng, Basu, Uttiya, Sebastiano, Vittorio, Byun, Minji, Sebra, Robert, Rosenberg, Brad R, Benner, Chris, Guccione, Ernesto, Marazzi, Ivan

“…Endogenous retroviruses (ERVs) are remnants of ancient parasitic infections and comprise sizable portions of most genomes. Although epigenetic mechanisms…”
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Elucidating and Targeting Mechanisms of Resistance to HER2-targeted Antibodies in Breast Cancer by Gale, Molly

“…HER2-targeted antibodies have drastically improved outcomes for patients diagnosed with HER2+ breast cancer. Their inclusion in breast cancer treatment…”
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The Role of the Histone Demethyltransferase Gene JMJD1C and H3K9 Methylation in Multiple Myeloma by LoBello, Janine, Gale, Molly, Watanabe, A, Hostetter, Galen, Fonseca, Rafael, Salhia, Bodour

“…Abstract 3527 Increasing evidence compiled from our lab and several others is illuminating the importance of epigenetic mechanisms in the pathogenesis of…”
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DNA Methylation in Multiple Myeloma Is Weakly Associated with Gene Transcription by Jung, Sungwon, Seungchan, Kim, Gale, Molly, Fonseca, Rafael, Carpten, John, Salhia, Bodour

“…Abstract 1285 Recent studies have now demonstrated that both genic and global hypomethylation characterizes the multiple myeloma (MM) epigenome. We previously…”
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