Search Results - "Gale, Jeremy D"

A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema by Gale, Jeremy D, Berger, Brian, Gilbert, Steven, Popa, Serghei, Sultan, Marla B, Schachar, Ronald A, Girgenti, Douglas, Perros-Huguet, Christelle

“…Ligands for the proinflammatory C-C chemokine receptor types 2 and 5 (CCR2 and CCR5) are elevated in the eyes of patients with diabetic macular edema (DME). We…”
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Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study by Singh, Ravi Shankar P., Pradhan, Vivek, Roberts, Erika S., Scaramozza, Matthew, Kieras, Elizabeth, Gale, Jeremy D., Peeva, Elena, Vincent, Michael S., Banerjee, Anindita, Fensome, Andrew, Dowty, Martin E., Winkle, Peter, Tehlirian, Christopher

“…Selective inhibition of tyrosine kinase 2 (TYK2) may offer therapeutic promise in inflammatory conditions, with its role in downstream pro‐inflammatory…”
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Advantages of a wholly Bayesian approach to assessing efficacy in early drug development: a case study by Walley, Rosalind J., Smith, Claire L., Gale, Jeremy D., Woodward, Phil

“…This paper illustrates how the design and statistical analysis of the primary endpoint of a proof‐of‐concept study can be formulated within a Bayesian…”
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Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors by Rosin, Diane L, Hall, J Perry, Zheng, Shuqiu, Huang, Liping, Campos-Bilderback, Silvia, Sandoval, Ruben, Bree, Andrea, Beaumont, Kevin, Miller, Emily, Larsen, Jennifer, Hariri, Ghazal, Kaila, Neelu, Encarnacion, Iain M, Gale, Jeremy D, van Elsas, Andrea, Molitoris, Bruce A, Okusa, Mark D

“…Adenosine triphosphate (ATP) released from injured or dying cells is a potent pro-inflammatory "danger" signal. Alkaline phosphatase (AP), an endogenous enzyme…”
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Pregabalin inhibits accelerated defecation and decreased colonic nociceptive threshold in sensitized rats by Ohashi-Doi, Katsuyo, Gale, Jeremy D., Kurebayashi, Yoichi

“…Pregabalin, a ligand of α 2δ subunits of voltage-gated calcium channels, reduces visceral hypersensitivity associated with irritable bowel syndrome. However,…”
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Oral tyrosine kinase 2 inhibitor PF-06826647 demonstrates efficacy and an acceptable safety profile in participants with moderate-to-severe plaque psoriasis in a phase 2b, randomized, double-blind, placebo-controlled study by Tehlirian, Christopher, Singh, Ravi Shankar P., Pradhan, Vivek, Roberts, Erika S., Tarabar, Sanela, Peeva, Elena, Vincent, Michael S., Gale, Jeremy D.

“…Psoriasis treatments lack durable efficacy and have inconvenient administration, highlighting the need for new therapies. To evaluate the efficacy and safety…”
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A Placebo-controlled Study of PF-06473871 (Anti-Connective Tissue Growth Factor Antisense Oligonucleotide) in Reducing Hypertrophic Skin Scarring by Gale, Jeremy D., Jensen, Jeff, Berman, Gabe, Freimuth, William, Li, Gang, Pleil, Andreas, Kutty, Malik, Rosenthal, Andrew, Boswell, C.B., Noah, V., E. Magnus, Young, Leroy

“…Connective tissue growth factor (CTGF) is a matricellular protein that plays a key role in wound healing and scar formation. Inhibition of CTGF by a specific…”
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Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study by Sandborn, William J., Danese, Silvio, Leszczyszyn, Jaroslaw, Romatowski, Jacek, Altintas, Engin, Peeva, Elena, Hassan-Zahraee, Mina, Vincent, Michael S., Reddy, Padmalatha S., Banfield, Christopher, Salganik, Mikhail, Banerjee, Anindita, Gale, Jeremy D., Hung, Kenneth E.

“…The efficacy and safety of ritlecitinib (oral JAK3/TEC family kinase inhibitor) and brepocitinib (oral TYK2/JAK1 inhibitor) as induction therapy were assessed…”
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Alternative Endoscopy Reading Paradigms Determine Score Reliability and Effect Size in Ulcerative Colitis by Reinisch, Walter, Pradhan, Vivek, Ahmad, Saira, Zhang, Zhen, Gale, Jeremy D

“…Central reading of endoscopy is advocated by regulatory agencies for clinical trials in ulcerative colitis [UC]. It is uncertain whether the local/site reader…”
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Target Occupancy and Functional Inhibition of JAK3 and TEC Family Kinases by Ritlecitinib in Healthy Adults: An Open-Label, Phase 1 Study by Martin, David A, Telliez, Jean-Baptiste, Pleasic-Williams, Susan, Zhang, Ying, Tierney, Brendan, Blatnik, Matthew, Gale, Jeremy D, Banfield, Chris, Zhou, Yifan, Lejeune, Alexandre, Zwillich, Samuel H, Stevens, Erin, Tiwari, Neeraj, Kieras, Elizabeth, Karanam, Ashwin

“…Ritlecitinib is a small molecule in clinical development that covalently and irreversibly inhibits Janus kinase 3 (JAK3) and the TEC family of kinases (BTK,…”
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Baseline Serum and Stool Microbiome Biomarkers Predict Clinical Efficacy and Tissue Molecular Response After Ritlecitinib Induction Therapy in Ulcerative Colitis by Hassan-Zahraee, Mina, Ye, Zhan, Xi, Li, Dushin, Elizabeth, Lee, Julie, Romatowski, Jacek, Leszczyszyn, Jaroslaw, Danese, Silvio, Sandborn, William J, Banfield, Christopher, Gale, Jeremy D, Peeva, Elena, Longman, Randy S, Hyde, Craig L, Hung, Kenneth E

“…Ritlecitinib, an oral JAK3/TEC family kinase inhibitor, was well-tolerated and efficacious in the phase 2b VIBRATO study in participants with…”
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Biomarkers of Crohn’s Disease to Support the Development of New Therapeutic Interventions by Porter, Amy C, Aubrecht, Jiri, Birch, Chandler, Braun, Jonathan, Cuff, Carolyn, Dasgupta, Suryasarathi, Gale, Jeremy D, Hinton, Robert, Hoffmann, Steven C, Honig, Gerard, Linggi, Bryan, Schito, Marco, Casteele, Niels Vande, Sauer, John-Michael

“…Abstract Background Currently, 2 coprimary end points are used by health authorities to determine the effectiveness of therapeutic interventions in patients…”
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Histological sub‐classification of cirrhosis using collagen proportionate area in patients with chronic hepatitis C by Papatheodoridi, Margarita, Hall, Andrew R., Rodríguez‐Perálvarez, Manuel, Pieri, Giulia, Germani, Giacomo, Gale, Jeremy D., Burgess, Gary C., Pinzani, Massimo, Dhillon, Amar P., Tsochatzis, Emmanuel A.

“…Collagen proportionate area (CPA, %) is used to quantify liver fibrosis. Here, we assessed CPA performance to sub‐classify cirrhosis. CPA was measured in…”
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Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy by Gale, Jeremy D, Gilbert, Steven, Blumenthal, Samuel, Elliott, Tom, Pergola, Pablo E, Goteti, Kosalaram, Scheele, Wim, Perros-Huguet, Christelle

“…Inflammatory cell recruitment, which is potentially mediated by the monocyte chemoattractant protein 1/C-C chemokine receptor type 2 (CCR2) system and by C-C…”
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The use of novel promotility and prosecretory agents for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation by Gale, Jeremy D.

“…Chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (C-IBS) are commonly reported gastrointestinal (GI) disorders that have a…”
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Alpha 2 Delta (α(2)δ) Ligands, Gabapentin and Pregabalin: What is the Evidence for Potential Use of These Ligands in Irritable Bowel Syndrome by Gale, Jeremy D, Houghton, Lesley A

“…Irritable bowel syndrome (IBS) is a complex disorder that is characterized by abdominal pain and altered bowel habit, and often associates with other…”
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T1384 Effects of CP-464709, a Ghrelin Receptor Agonist, On Gastric Antral Motility and Gastric Emptying in Dogs by Komada, Tohru, Ochi, Yasuo, Gale, Jeremy D

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Evidence for functional ghrelin receptors on parasympathetic preganglionic neurons of micturition control pathways in the rat by Ferens, Dorota M, Yin, Lei, Ohashi-Doi, Katsuyo, Habgood, Mark, Bron, Romke, Brock, James A, Gale, Jeremy D, Furness, John B

“…Summary 1. Previous work indicates that agonists of ghrelin receptors can act within the spinal cord to stimulate autonomic outputs to the colorectum and to…”
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T1249 Effect of Two Novel, Selective Alpha4beta2 Nicotinic Receptor Partial Agonists On Restraint Stress-Induced Defecation in Rats by Ohashi-Doi, Katsuyo, Kawai, Mitsuhisa, Furness, John B, Gale, Jeremy D

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235 PF-04548043, a Novel Motilin Receptor Agonist, Increases Gastric Emptying in Healthy Volunteers and Does Not Undergo Tachyphylaxis by Gale, Jeremy D, Colman, Peter J, Kantaridis, Constantino, Claes, Catherine, Tutuian, Radu

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