Search Results - "Galdino, Suely Lins"
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Overview on plant antimicrobial peptides
Published in Current protein & peptide science (01-05-2010)“…Mechanisms related to biotic interactions, such as pathogen attack, herbivory and symbiosis are important challenges to higher plants and have been widely…”
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2
Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions
Published in PloS one (04-10-2013)“…The present study aimed to show the in vivo mechanisms of action of an indole-thiazolidine molecule peroxisome-proliferator activated receptor pan-agonist…”
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3
The evolution of drugs on schistosoma treatment: looking to the past to improve the future
Published in Mini reviews in medicinal chemistry (01-04-2013)“…Schistosomiasis is a devastating worldwide widespread tropical disease that currently affects more than 230 million people, making it an issue of great…”
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Development of novel therapeutic drugs in humans from plant antimicrobial peptides
Published in Current protein & peptide science (01-05-2010)“…All living organisms, ranging from microorganisms to plants and mammals, have evolved mechanisms to actively defend themselves against pathogen attack. A wide…”
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Increased Serum Interleukin 22 in Patients with Rheumatoid Arthritis and Correlation with Disease Activity
Published in Journal of rheumatology (01-07-2012)“…To analyze the role of interleukin 22 (IL-22) in rheumatoid arthritis (RA). IL-22 serum levels were measured in 83 patients with established RA under treatment…”
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Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients
Published in Clinics (São Paulo, Brazil) (01-06-2013)“…Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently,…”
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Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPARγ ligands
Published in Bioorganic & medicinal chemistry (01-06-2010)“…Trend between the docking scores (PPARγ receptor) and the anti-inflammatory activity of eight new synthesized 5-arylidene-3-benzyl-thiazolidine-2,4-diones…”
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Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives
Published in Bioorganic & medicinal chemistry (01-06-2012)“…Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as…”
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Metabolism evaluation of the anticancer candidate AC04 by biomimetic oxidative model and rat liver microsomes
Published in European journal of medicinal chemistry (01-09-2011)“…Jacobsen reagents, in the presence of monooxygen donors, appear as an alternative to produce metabolites from biological active compounds. This reaction may…”
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Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities
Published in European journal of medicinal chemistry (01-10-2007)“…New arylidene-thiazolidinediones (ATZDs) were synthesized and evaluated in the alloxan-induced hyperglycemia mice model. The molecular target taken into…”
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Graduação e pós-graduação em Farmácia no Brasil: convergências e fortalecimento de capacidades
Published in Interface (Botucatu, Brazil) (01-12-2013)Get full text
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Biological and immunological activity of new imidazolidines against adult worms of Schistosoma mansoni
Published in Parasitology research (1987) (01-08-2010)“…The only drug available for treating schistosomiasis is praziquantel, however there are already reports of resistance to its use in treatment, making it…”
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Validation of a UV-spectrophotometric analytical method for determination of LPSF/AC04 from inclusion complex and liposomes
Published in Brazilian Journal of Pharmaceutical Sciences (01-03-2015)“…The aim of this study was to develop and validate a UV spectrophotometric method for determination of LPSF/AC04 from inclusion complex and encapsulated into…”
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14
Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice
Published in TheScientificWorld (01-01-2012)“…Previous studies conducted with the imidazolidinic derivative 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one (LPSF-PT05) show outstanding activity…”
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15
DEVELOPMENT AND VALIDATION OF AN LC-MS/MS METHOD FOR THE PRE-CLINICAL PHARMACOKINETIC INVESTIGATION OF THE ANTICANCER CANDIDATE AC04 IN RODENTS
Published in Journal of liquid chromatography & related technologies (01-01-2011)“…A liquid chromatography-tandem mass spectrometry method was developed for accurate quantification of the acridinic anticancer candidate AC04…”
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16
Efficient synthesis of benzothiazine and acrylamide compounds
Published in Química nova (2010)“…This article describes the synthesis of the new (2Z)-2-(4-methoxybenzylidene)-6-nitro-4H -benzo[1,4]thiazin-3-one,…”
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Perfil de pacientes com artrite reumatoide em uso de inibidores do Fator de Necrose Tumoral alfa (TNF-α), cadastrados no Componente Especializado da Assistência Farmacêutica de Pernambuco, Brasil
Published in Revista de ciências farmacêuticas básica e aplicada (01-04-2014)“…Em Pernambuco, por meio de financiamento federal do Ministério da Saúde, a Secretaria Estadual de Saúde, provê, ao tratamento da Artrite Reumatóide (AR), os…”
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On the application of knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study
Published in Química Nova (01-10-2006)“…The synthesis and physico-chemical properties of new 6-acetylamino or 6-benzoyl-amino 2-benzylidene-4-methyl-4H-benzo[1,4]thiazin-3-ones and 6-benzoylamino or…”
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Anti-inflammatory and antinociceptive activities of indole–imidazolidine derivatives
Published in International immunopharmacology (01-11-2011)“…Non-steroidal anti-inflammatory drugs (NSAIDs) represent a group of approximately 50 different medicines that are widely prescribed for the management of…”
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Synthesis, in vitro anticancer activity and in silico study of new disubstituted thiazolidinedione derivatives
Published in Medicinal chemistry research (01-06-2014)“…Thiazolidinediones are known to have antidiabetic activity, but new activities are being discovered every year; among these, their anticancer activity has…”
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