Search Results - "Galbán, Stefanie"

Computed tomography–based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression by Galbán, Craig J, Han, Meilan K, Boes, Jennifer L, Chughtai, Komal A, Meyer, Charles R, Johnson, Timothy D, Galbán, Stefanie, Rehemtulla, Alnawaz, Kazerooni, Ella A, Martinez, Fernando J, Ross, Brian D

“…Chronic obstructive pulmonary disease (COPD) is now known to be a heterogeneous disorder, hence the pressing need to develop imaging biomarkers to…”
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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice by Collins, Meredith A, Bednar, Filip, Zhang, Yaqing, Brisset, Jean-Christophe, Galbán, Stefanie, Galbán, Craig J, Rakshit, Sabita, Flannagan, Karen S, Adsay, N Volkan, Pasca di Magliano, Marina

“…Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRASG12D, that result in a dominant-active form of the KRAS…”
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RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α by Galbán, Stefanie, Kuwano, Yuki, Pullmann, Rudolf, Martindale, Jennifer L., Kim, Hyeon Ho, Lal, Ashish, Abdelmohsen, Kotb, Yang, Xiaoling, Dang, Youngjun, Liu, Jun O., Lewis, Stephen M., Holcik, Martin, Gorospe, Myriam

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Metastatic pancreatic cancer is dependent on oncogenic Kras in mice by Collins, Meredith A, Brisset, Jean-Christophe, Zhang, Yaqing, Bednar, Filip, Pierre, Josette, Heist, Kevin A, Galbán, Craig J, Galbán, Stefanie, di Magliano, Marina Pasca

“…Pancreatic cancer is one of the deadliest human malignancies, and its prognosis has not improved over the past 40 years. Mouse models that spontaneously…”
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Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3‑Kinase (PI3K) by Van Dort, Marcian E, Hong, Hao, Wang, Hanxiao, Nino, Charles A, Lombardi, Rachel L, Blanks, Avery E, Galbán, Stefanie, Ross, Brian D

“…The synthesis of a series of single entity, bifunctional MEK1/PI3K inhibitors achieved by covalent linking of structural analogs of the ATP-competitive PI3K…”
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A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis by Galbán, Stefanie, Apfelbaum, April A, Espinoza, Carlos, Heist, Kevin, Haley, Henry, Bedi, Karan, Ljungman, Mats, Galbán, Craig J, Luker, Gary D, Dort, Marcian Van, Ross, Brian D

“…Responses to targeted therapies frequently are brief, with patients relapsing with drug-resistant tumors. For oncogenic MEK and BRAF inhibition, drug…”
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The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independent of its catalytic activity by Huang, Wei, Ray, Paramita, Ji, Wenbin, Wang, Zhuwen, Nancarrow, Derek, Chen, Guoan, Galbán, Stefanie, Lawrence, Theodore S., Beer, David G., Rehemtulla, Alnawaz, Ramnath, Nithya, Ray, Dipankar

“…We previously reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1) increases lung cancer cell proliferation by activating…”
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Regulation of the Copper Chaperone CCS by XIAP-Mediated Ubiquitination by Brady, Graham F., Galbán, Stefanie, Liu, Xuwen, Basrur, Venkatesha, Gitlin, Jonathan D., Elenitoba-Johnson, Kojo S. J., Wilson, Thomas E., Duckett, Colin S.

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CT-Based Local Distribution Metric Improves Characterization of COPD by Hoff, Benjamin A., Pompe, Esther, Galbán, Stefanie, Postma, Dirkje S., Lammers, Jan-Willem J., ten Hacken, Nick H. T., Koenderman, Leo, Johnson, Timothy D., Verleden, Stijn E., de Jong, Pim A., Mohamed Hoesein, Firdaus A. A., van den Berge, Maarten, Ross, Brian D., Galbán, Craig J.

“…Parametric response mapping (PRM) of paired CT lung images has been shown to improve the phenotyping of COPD by allowing for the visualization and…”
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Evaluation of Concurrent Radiation, Temozolomide and ABT-888 Treatment Followed by Maintenance Therapy with Temozolomide and ABT-888 in a Genetically Engineered Glioblastoma Mouse Model by Lemasson, Benjamin, Wang, Hanxiao, Galbán, Stefanie, Li, Yinghua, Zhu, Yuan, Heist, Kevin A, Tsein, Christina, Chenevert, Thomas L, Rehemtulla, Alnawaz, Galbán, Craig J, Holland, Eric C, Ross, Brian D

“…Abstract Despite the use of ionizing radiation (IR) and temozolomide (TMZ), outcome for glioblastoma (GBM) patients remains dismal. Poly (ADP-ribose)…”
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Identification and Functional Outcome of mRNAs Associated with RNA-Binding Protein TIA-1 by López de Silanes, Isabel, Galbán, Stefanie, Martindale, Jennifer L., Yang, Xiaoling, Mazan-Mamczarz, Krystyna, Indig, Fred E., Falco, Geppino, Zhan, Ming, Gorospe, Myriam

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Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively by WEBER, Thomas G, OSL, Franz, RENNER, Anja, PÖSCHINGER, Thomas, GALBAN, Stefanie, REHEMTULLA, Alnawaz, SCHEUER, Werner

“…High-grade gliomas often possess an impaired blood-brain barrier (BBB), which allows delivery of large molecules to brain tumors. However, achieving optimal…”
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Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma by Pitter, Kenneth L, Galbán, Craig J, Galbán, Stefanie, Tehrani, Omid Saeed, Saeed-Tehrani, Omid, Li, Fei, Charles, Nikki, Bradbury, Michelle S, Becher, Oren J, Chenevert, Thomas L, Rehemtulla, Alnawaz, Ross, Brian D, Holland, Eric C, Hambardzumyan, Dolores

“…Platelet derived growth factor receptor (PDGFR) activity is deregulated in human GBM due to amplification and rearrangement of the PDGFR-alpha gene locus or…”
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Apoptosis-Inducing Factor Is a Target for Ubiquitination through Interaction with XIAP by Wilkinson, John C, Wilkinson, Amanda S, Galbán, Stefanie, Csomos, Rebecca A, Duckett, Colin S

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Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer by Williams, Terence M, Flecha, Athena R, Keller, Paul, Ram, Ashwin, Karnak, David, Galbán, Stefanie, Galbán, Craig J, Ross, Brian D, Lawrence, Theodore S, Rehemtulla, Alnawaz, Sebolt-Leopold, Judith

“…There is an urgent need for the development of novel therapies to treat pancreatic cancer, which is among the most lethal of all cancers. KRAS-activating…”
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Prospective Analysis of Parametric Response Map-Derived MRI Biomarkers: Identification of Early and Distinct Glioma Response Patterns Not Predicted by Standard Radiographic Assessment by GALBAN, Craig J, CHENEVERT, Thomas L, SEBOLT-LEOPOLD, Judith S, REHEMTULLA, Alnawaz, ROSS, Brian D, MEYER, Charles R, TSIEN, Christina, LAWRENCE, Theodore S, HAMSTRA, Daniel A, JUNCK, Larry, SUNDGREN, Pia C, JOHNSON, Timothy D, GALBAN, Stefanie

“…Currently, radiologic response of brain tumors is assessed according to the Macdonald criteria 10 weeks from the start of therapy. There exists a critical need…”
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RNA-Binding Protein HuR Enhances p53 Translation in Response to Ultraviolet Light Irradiation by Mazan-Mamczarz, Krystyna, Galbán, Stefanie, de Silanes, Isabel López, Martindale, Jennifer L., Atasoy, Ulus, Keene, Jack D., Gorospe, Myriam

“…Exposure to short-wavelength UV light (UVC) strongly induces p53 expression. In human RKO colorectal carcinoma cells, this increase was not due to elevated p53…”
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Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168) by Van Dort, Marcian E, Galbán, Stefanie, Nino, Charles A, Hong, Hao, Apfelbaum, April A, Luker, Gary D, Thurber, Greg M, Atangcho, Lydia, Besirli, Cagri G, Ross, Brian D

“…The structure-based design of a new single entity, MEK/PI3K bifunctional inhibitor (7, ST-168), which displays improved MEK1 and PI3K isoform inhibition, is…”
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Noninvasive Monitoring of Pharmacodynamics and Kinetics of a Death Receptor 5 Antibody and Its Enhanced Apoptosis Induction in Sequential Application with Doxorubicin by Weber, Thomas G, Pöschinger, Thomas, Galbán, Stefanie, Rehemtulla, Alnawaz, Scheuer, Werner

“…Abstract Induction of apoptosis plays a crucial role in the response of tumors to treatment. Thus, we investigated the pharmacodynamics and tumor saturation…”
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Quantitative CT Correlates with Local Inflammation in Lung of Patients with Subtypes of Chronic Lung Allograft Dysfunction by Ram, Sundaresh, Verleden, Stijn E, Bell, Alexander J, Hoff, Benjamin A, Labaki, Wassim W, Murray, Susan, Vanaudenaerde, Bart M, Vos, Robin, Verleden, Geert M, Kazerooni, Ella A, Galbán, Stefanie, Hatt, Charles R, Han, Meilan K, Lama, Vibha N, Galbán, Craig J

“…Chronic rejection of lung allografts has two major subtypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), which present…”
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