Search Results - "Galati, Melissa A"

Comprehensive Analysis of Hypermutation in Human Cancer by Campbell, Brittany B., Light, Nicholas, Fabrizio, David, Zatzman, Matthew, Fuligni, Fabio, de Borja, Richard, Davidson, Scott, Edwards, Melissa, Elvin, Julia A., Hodel, Karl P., Zahurancik, Walter J., Suo, Zucai, Lipman, Tatiana, Wimmer, Katharina, Kratz, Christian P., Bowers, Daniel C., Laetsch, Theodore W., Dunn, Gavin P., Johanns, Tanner M., Grimmer, Matthew R., Smirnov, Ivan V., Larouche, Valérie, Samuel, David, Bronsema, Annika, Osborn, Michael, Stearns, Duncan, Raman, Pichai, Cole, Kristina A., Storm, Phillip B., Yalon, Michal, Opocher, Enrico, Mason, Gary, Thomas, Gregory A., Sabel, Magnus, George, Ben, Ziegler, David S., Lindhorst, Scott, Issai, Vanan Magimairajan, Constantini, Shlomi, Toledano, Helen, Elhasid, Ronit, Farah, Roula, Dvir, Rina, Dirks, Peter, Huang, Annie, Galati, Melissa A., Chung, Jiil, Ramaswamy, Vijay, Irwin, Meredith S., Aronson, Melyssa, Durno, Carol, Taylor, Michael D., Rechavi, Gideon, Maris, John M., Bouffet, Eric, Hawkins, Cynthia, Costello, Joseph F., Meyn, M. Stephen, Pursell, Zachary F., Malkin, David, Tabori, Uri, Shlien, Adam

“…We present an extensive assessment of mutation burden through sequencing analysis of >81,000 tumors from pediatric and adult patients, including tumors with…”
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DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells by Chung, Jiil, Maruvka, Yosef E, Sudhaman, Sumedha, Kelly, Jacalyn, Haradhvala, Nicholas J, Bianchi, Vanessa, Edwards, Melissa, Forster, Victoria J, Nunes, Nuno M, Galati, Melissa A, Komosa, Martin, Deshmukh, Shriya, Cabric, Vanja, Davidson, Scott, Zatzman, Matthew, Light, Nicholas, Hayes, Reid, Brunga, Ledia, Anderson, Nathaniel D, Ho, Ben, Hodel, Karl P, Siddaway, Robert, Morrissy, A Sorana, Bowers, Daniel C, Larouche, Valérie, Bronsema, Annika, Osborn, Michael, Cole, Kristina A, Opocher, Enrico, Mason, Gary, Thomas, Gregory A, George, Ben, Ziegler, David S, Lindhorst, Scott, Vanan, Magimairajan, Yalon-Oren, Michal, Reddy, Alyssa T, Massimino, Maura, Tomboc, Patrick, Van Damme, An, Lossos, Alexander, Durno, Carol, Aronson, Melyssa, Morgenstern, Daniel A, Bouffet, Eric, Huang, Annie, Taylor, Michael D, Villani, Anita, Malkin, David, Hawkins, Cynthia E, Pursell, Zachary F, Shlien, Adam, Kunkel, Thomas A, Getz, Gad, Tabori, Uri

“…Although replication repair deficiency, either by mismatch repair deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in…”
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Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition by Campbell, Brittany B, Galati, Melissa A, Stone, Simone C, Riemenschneider, Alexandra N, Edwards, Melissa, Sudhaman, Sumedha, Siddaway, Robert, Komosa, Martin, Nunes, Nuno M, Nobre, Liana, Morrissy, A Sorana, Zatzman, Matthew, Zapotocky, Michal, Joksimovic, Lazar, Kalimuthu, Sangeetha N, Samuel, David, Mason, Gary, Bouffet, Eric, Morgenstern, Daniel A, Aronson, Melyssa, Durno, Carol, Malkin, David, Maris, John M, Taylor, Michael D, Shlien, Adam, Pugh, Trevor J, Ohashi, Pamela S, Hawkins, Cynthia E, Tabori, Uri

“…The RAS/MAPK pathway is an emerging targeted pathway across a spectrum of both adult and pediatric cancers. Typically, this is associated with a single,…”
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Cancers from Novel Pole -Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade by Galati, Melissa A, Hodel, Karl P, Gams, Miki S, Sudhaman, Sumedha, Bridge, Taylor, Zahurancik, Walter J, Ungerleider, Nathan A, Park, Vivian S, Ercan, Ayse B, Joksimovic, Lazar, Siddiqui, Iram, Siddaway, Robert, Edwards, Melissa, de Borja, Richard, Elshaer, Dana, Chung, Jiil, Forster, Victoria J, Nunes, Nuno M, Aronson, Melyssa, Wang, Xia, Ramdas, Jagadeesh, Seeley, Andrea, Sarosiek, Tomasz, Dunn, Gavin P, Byrd, Jonathan N, Mordechai, Oz, Durno, Carol, Martin, Alberto, Shlien, Adam, Bouffet, Eric, Suo, Zucai, Jackson, James G, Hawkins, Cynthia E, Guidos, Cynthia J, Pursell, Zachary F, Tabori, Uri

“…mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype-phenotype correlation, and therapeutic…”
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